Identification of human papillomavirus in esophageal squamous papillomas

Abstract

This study provides identification of HPV infection in almost 80% of ESP using either ACISH or PCR; overall, all of these lesions show low expression of cell-cycle markers. We suggest ACISH as an alternative diagnostic tool for HPV detection in ESP.

Human Papilomavirus Infection and P16 Ink4a Hypermethylation in a Case of Esophageal Papillomatosis

“…As described by Talamini et al (2000), ESCP did not represent a risk of development of malignancy. In agreement with them, Bohn et al (2008) found prevailing HPV infection by lowrisk types, with no association with dysplastic changes or malignant transformation. Nevertheless, Syrjänen & Syrjanen (2012) described that, similarly to cervical cancer development, there are no doubts that ESCC develops through distinct precursor lesions, namely ESCP but no prospective follow-up study has been published till now.…”

“…Recently, epigenetic modification of p16INK4A by hypermethylation has been implicated in cancer development, leading to gene silencing of tumor suppressor proteins (Bohn et al 2008). Our results pointed to a methylated host DNA.…”

“…Esophageal squamous cell papillomas (ESCP) have been found to be associated with different conditions, including gastro-esophageal reflux, esophagitis, hiatal hernia, inflammation and trauma; also by the fact that most of the ESCP are located in lower level of the esophagus (Mosca et al 2001;Bohn et al 2008). Talamini et al (2000) found that in the Italian population, ESPs are located mostly in the middle third and secondarily, in the lower third; this study also reported a very low prevalence of cases associated with HPV (human papillomavirus) and implied that alcohol intake and cigarette smoking were risks factors.…”

“…Several studies have reported the presence of HPV DNA in benign ESCP (Mosca et al 2001, Bohn et al 2008Afonso et al 2010), however, HPV was not consistently identified (Poljack et al 1995;Talamini et al 2000). The role of HPV in these benign lesions still remains contradictory and studies report a wide variation on prevalence rates ranging from 0% to 100%.…”

Human papillomavirus detection and p16 methylation pattern in a case of esophageal papilloma

“…Esophageal squamous papillomas (ESPs) are uncommon benign lesions, usually asymptomatic and often discovered as incidental findings. The role of HPV in these benign lesions is controversial, with a wide variation in prevalence ranging from 0 to 100% having been reported in several studies (5). As suggested by Odze et al (6), the detection of HPV in ESPs may be of a great value in terms of the follow-up of lesions associated with genotypes implicated in the genesis of premalignant and malignant lesions in squamous epithelial-lined tissues, including the nasal cavity, pharynx and anogenital tract.…”