Identification of human papillomavirus types in oral verruca vulgaris

Adler‐Storthz, Karen; Newland, J R; Tessin, B. A.; Yeudall, W. Andrew; Shillitoe, Edward J.

doi:10.1111/j.1600-0714.1986.tb00613.x

Cited by 60 publications

(32 citation statements)

References 15 publications

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“…Laryngeal papilloma are exclusively confined to HPV 6 and 11 and FEH exclusively in HPV 13 and 32, respectively (16,21,24). Benign oral lesions were found associated with HPV 6,11,30, 45 and 55. However, HPV 30,45,52 and 55 were found in rather rare cases of squamous papilloma and verruca vulgaris (16)(17)(18)(19)(20)(23)(24)(25)(26).…”

Section: Mucosal Hpv Types Of the Oral Cavitymentioning

confidence: 99%

“…Seventeen mucosal HPV types (HPV 6,11,13,16,18,30,31,32,33,35,45,52,55,59,69, 72 and 73) were identified from a variety of oral lesions including oral wart, oral papilloma, oral condylomata, laryngeal papilloma, FEH and squamous cell carcinoma seen in Table 1 (b) (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). Laryngeal papilloma are exclusively confined to HPV 6 and 11 and FEH exclusively in HPV 13 and 32, respectively (16,21,24).…”

Section: Mucosal Hpv Types Of the Oral Cavitymentioning

confidence: 99%

“…Seven cutaneous HPV types (HPV 1, 2, 3, 4, 7, 10 and 57) were detected in the oral cavity seen in Table 1 (a) (7)(8)(9)(10)(11)(12)(13)(14)(15). The oral cavity is a mucosal area and cutaneous HPV types may be transmitted by sexual contact as a sexually transmitted disease and/or autoinoculation from one region to another in the same person.…”

Section: Cutaneous Hpv Types Of the Oral Cavitymentioning

confidence: 99%

“…The oral cavity is a mucosal area and cutaneous HPV types may be transmitted by sexual contact as a sexually transmitted disease and/or autoinoculation from one region to another in the same person. Oral verruca vulgaris is one of the most common cutaneous HPVassociated oral lesions (8)(9)(10)(11)(12)(13). Oral verruca vulgaris appearing as whitish, sessile, papillomatous, rough-surfaced lesions cannot be clinically distinguished from squamous cell papilloma (Figs.…”

Section: Cutaneous Hpv Types Of the Oral Cavitymentioning

confidence: 99%

“…HPV is also broadly categorized into low, intermediate and highrisk types in accordance with their potential to induce or their association with malignant lesions (6). In oral lesions 24 genotypes have been identified 2,3,4,6,7,10,11,13,16,18,30,31,32,33,35,45,52,55,57,59,69,72 and 73) (7-27) ( Table 1).The HPV genome is comprised of early (E) genes that function primarily in episomal replication and late (L) genes that encode the viral capsid proteins. HPV 16 genome map is shown in Fig.…”

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confidence: 99%

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Human Papillomavirus in the Oral Cavity

Terai

Takagi

2001

Oral Med Pathol

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Human papillomavirus (HPV) cannot be efficiently propagated in tissue cultures or animal models. However, molecular biological technology has made it possible to clone viral genomes, which can then be compared and also used as reagents in clinical and epidemiological studies.Today HPV infections are recognized as being responsible for inducing cancers worldwide and it is expected that HPV-based technologies will provide the tools to prevent and treat HPV-induced cancers. In this review, we focus on the association between oral lesions and HPV infection and the natural history of HPV infection of the oral cavity. We also evaluate the HPV detection methods in this important and fundamental matter for the HPV studies. We then discuss the potential targeted molecular therapies and prevention of a variety of HPVinduced diseases of the oral cavity, including oral cancers. Key words: HPV, human papillomavirus, oral cavityCorrespondence : Minoru Takagi, Molecular Pathology, Oral Restitution, Oral Health Science, Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113- 8549, JapanPhone: +81-3-5803-5451, Fax: +81-3-5803-0188 IntroductionHuman papillomavirus (HPV) is a small, nonenveloped and double stranded circular DNA virus, about 8,000 bp in length, with a well-known physical structure and gene organization (1). HPV belongs in the subfamily papillomavirus (PV) of the papovavirus family, which are widely distributed in nature and infect many higher vertebrates including cattle, rabbits and dogs (1). It is thought that the viruses may have co-evolved with their hosts (2). They are highly species-specific species, having one or more of its own PVs, and viruses of one species do not infect other species (1).HPV is classified into more than 100 types, including 84 clones and others detected by PCR (3). To be recognized as a distinct HPV genome, the full genome should be cloned and the sequence of the L1 gene should be no more than 90% similar to previously assigned and referenced HPVs (4). HPVs naturally fall into two groups: mucosal HPVs and cutaneous HPVs according to the anatomic site of infection and/or phylogenetic analysis (5). Some HPV infections can lead to malignant lesions depending on HPV genotypes and infection persistence. HPV is also broadly categorized into low, intermediate and highrisk types in accordance with their potential to induce or their association with malignant lesions (6). In oral lesions 24 genotypes have been identified 2,3,4,6,7,10,11,13,16,18,30,31,32,33,35,45,52,55,57,59,69,72 and 73) (7-27) ( Table 1).The HPV genome is comprised of early (E) genes that function primarily in episomal replication and late (L) genes that encode the viral capsid proteins. HPV 16 genome map is shown in Fig. 1. The L1 and L2 genes code for proteins that make up the viral major and minor capsid. The capsid encloses the viral genome and mediates viral entry into susceptible cells (28). Much of the immune response to infection is directed at the capsid protein (29). Based on experi...

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