Identification of Hydrogen Peroxide and Hydroxyl Radical as Mediators of LeukocyteInduced Myocardial Dysfunction

Potent Antioxidative Activity of Cacalol, a Sesquiterpene Contained inCacalia delphiniifoliaSleb et Zucc

“…The generation of free radicals has recently been suggested to play a major role in the progression of a wide range of pathological disturbances, including myocardial and cerebral ischemia, 1,2) atherosclerosis, 3) renal failure, 4) inflammation, 5) and rheumatoid arthritis. 6) Subsequent peroxidative disintegration of cells and organellar membranes has been particularly implicated in various pathological processes.…”

“…The resulting powder was extracted twice with a CH 2 Cl 2 -MeOH (1:1) solution (500 ml). The resulting extract (0.78 g) was subjected to silica gel chromatography [30 Â 200 mm, silica gel 60 (Merck)], using hexane-EtOAc (20:1) to yield 10.7 mg of cacalol (1 (c 0.2)). The inhibitory effect of 1 on lipid peroxidation in a rat brain homogenate 11) is shown in Fig.…”

Neutrophils superoxide anion generation during carvedilol therapy in patients with stable angina

“…It gives a new approach to understanding the mechanisms involved in generation and development of ischemic changes as well as possible pharmacological methods of limiting neutrophil-related injury. Activated neutrophils are recognized as a main source of free radicals [5][6][7]. Activated neutrophils, through the effect of membrane-related NADPH oxidase, produce large amounts of the superoxide anion (O 2 !…”

Antioxidative activity of the flower of Torenia fournieri

“…It has been suggested that the generation of free radicals plays a major role in the progression of a wide range of pathological disturbances, including myocardial and cerebral ischemia [1,2] and atherosclerosis [3]. Subsequent peroxidative disintegration of cellular and organellar membranes in particular has been implicated in various pathological processes [4].…”