Identification of
            <i>PTCSC3</i>
            as a Novel Locus for Large‐Vessel Ischemic Stroke: A Genome‐Wide Association Study

Lee, Tsong Hai; Ko, Tai‐Ming; Chen, Chien Hsiun; Lee, Ming Ta Michael; Chang, Yen Jung; Chang, Chien Hung; Huang, Kuo‐Lun; Chang, Tsin‐Yuan; Lee, Jiann Der; Chang, Ku Chou; Yang, Jing‐Tang; Wen, Ming; Wang, Chao Yung; Chen, Ying Ting; Hsieh, Chia San; Chou, Shu Yu; Liu, Yi Min; Chen, Hui-Wen; Liao, Hung Ting; Wang, Chia-Wen; Chen, Shih-Ping; Liang, Lu; Chen, Yuan Tsong; Wu, Jer Yuarn

doi:10.1161/jaha.115.003003

Cited by 24 publications

(17 citation statements)

References 20 publications

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“…Papillary thyroid carcinoma susceptibility candidate 3 is a newly identified lncRNA, which is predisposed expressed in papillary thyroid cancer . A study reported that PTCSC3, a 1152‐bp lncRNA, attenuated thyroid cancer by repressing cell proliferation and invasion .…”

Section: Discussionmentioning

confidence: 99%

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LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p

Tong

Zhang

Wang

et al. 2019

Clin Exp Pharma Physio

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Dysregulation of long non‐coding RNA papillary thyroid carcinoma susceptibility candidate 3 (lncRNA PTCSC3) has been found to correlate with various types of cancers. Quantitative RT‐PCR showed a down‐regulation of PTCSC3 in cervical cancer tissues compared with normal cervical tissues. The present study aimed to investigate the role of lncRNA PTCSC3 in cervical cancer and the underlying mechanisms. PTCSC3 was overexpressed in cervical cancer cell lines C‐33A and Hela by transfection with pcDNA3.1‐lncRNA PTCSC3 expressing plasmid. Overexpression of lncRNA PTCSC3 inhibited cell proliferation, induced cell cycle arrest, and suppressed cell invasion and migration using CCK8 assay, flow cytometry, Transwell assay and wound healing examination, respectively. Western blotting analysis showed that PTCSC3 overexpression decreased the expression of cyclinD1, matrix metalloproteinases 9 (MMP9), N‐cadherin and β‐catenin and increased E‐cadherin expression. Further, PTCSC3 negatively regulated miR‐574‐5p expression and dual‐luciferase assay verified the binding activity between miR‐574‐5p and lncRNA PTCSC3. Enforced up‐regulation of miR‐574‐5p abolished the inhibitory effect of lncRNA PTCSC3 on cervical cancer cell proliferation, invasiveness and mobility. Taken together, lncRNA PTCSC3 inhibited cell growth and metastasis via sponging miR‐574‐5p in cervical cancer. Therefore, we demonstrate the tumour‐suppressive function of lncRNA PTCSC3 in cervical cancer and suggest that PTCSC3 is a potential therapeutic target for cervical cancer.

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Section: Discussionmentioning

confidence: 99%

“…Papillary thyroid carcinoma susceptibility candidate 3 (PTCSC3) is a lncRNA gene located 3.2 kb downstream of SNPP rs944289 at chromosome 14q.13.3 . It has been reported that lncRNA PTCSC3 is associated with papillary thyroid cancer (PTC) susceptibility .…”

Section: Introductionmentioning

confidence: 99%

LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p

Tong

Zhang

Wang

et al. 2019

Clin Exp Pharma Physio

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“…These included variants at the 9p21 locus (25,26), ABO and HDAC9 (27,28). Several novel loci, which were associated with ischemic stroke or large-artery stroke, have been identified recently, including MMP12 (29), PTCSC3 (30), and ALDH2 (31). All of these studies shed light on the different pathogenic pathways underpinning stroke subtypes.…”

Section: Genetics Of Sporadic Ischemic Strokementioning

confidence: 99%

Towards precision medicine in ischemic stroke and transient ischemic attack

Lin

Liu

et al. 2018

Front Biosci

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Although there is no consensus on the exact definition of precision medicine, it is generally agreed upon that the term entails diagnosis and therapy tailored to the individual patient. Precision medicine has seen major advances in the past two decades, many of which are relevant to ischemic stroke or transient ischemic attack (TIA). Advances include substantial improvements in high-throughput technologies, collaborations between the fields of biology and medicine, increasingly advanced biomedical informatics, the development of multimodal brain imaging techniques, as well as the widespread usage of electronic medical records and big data. Precision medicine in ischemic stroke or TIA is still in its infancy, but there have already been changes in clinical care from a one-size-fits-all model to a more precise, individualized approach. However, further studies are urgently needed to bridge the gaps between clinical studies and precision clinical practice. We discuss here the advances and challenges for precision medicine in ischemic stroke or TIA at its current stage, focusing on genetic predispositions, pharmacogenetics, omics, brain imaging and big data.

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“…Evidence obtained from family, twin and animal model studies has revealed a genetic predisposition to the risk of ischemic stroke. [3][4][5][6] To date, genome-wide association studies have identified a series of genetic risk factors associated with ischemic stroke, [7][8][9][10][11] although some of them still need to be confirmed.…”

Section: Introductionmentioning

confidence: 99%

ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population

Yu¹,

Zhou²,

Luo

et al. 2017

The Journal of Gene Medicine

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Some previous studies suggested telomere length was associated with the risk of ischemic stroke (IS). The aim of this study was to further confirm the association between relative telomere length (RTL) and risk of IS and to especially explore its correlation with the risk of high-risk stroke population in southern Chinese Han. RTL was determined by using real-time quantitative polymerase chain reaction from 400 ischemic stroke patients, 409 high-risk stroke populations and 399 healthy controls. The correlations between the controls and the risk of high-risk and ischemic stroke were evaluated by using an unconditional logistic regression. IS patients have shown longer RTL than controls (median1.52vs1.11, p<0.001), while the high-risk stroke populations have shorter RTL than controls (median 1.05vs1.11, p=0.027). As compared with the second tertile, the first and third tertile were associated with the elevated risks of ischemic stroke (OR=2.88, 95%CI 1.88-4.41, p<0.001; OR=6.62, 95%CI 4.32-10.15, p<0.001) after adjustment for age and gender, while no significant differences were observed in high-risk stroke populations. Further analysis stratified by age (age≤60 years and >60 years) and gender suggested that the first and second tertile of RTL were correlated with the risk of IS in each group when the second tertile was used as a reference. However, the increased risk for high-risk stroke populations were only presented in the first tertile of RTL in the age≤60 years and female groups. the RTL was associated with an increased risk of ischemic stroke, while it elevated the risk of high-risk stroke in some specific subpopulations.

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Identification of PTCSC3 as a Novel Locus for Large‐Vessel Ischemic Stroke: A Genome‐Wide Association Study

Cited by 24 publications

References 20 publications

LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p

LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p

Towards precision medicine in ischemic stroke and transient ischemic attack

ZNF208 polymorphisms associated with ischemic stroke in a southern Chinese Han population

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