Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants

Terkawi, Mohamad Alaa; Kadoya, Ken; Takahashi, Daisuke; Tian, Yuan; Hamasaki, Masanari; Matsumae, Gen; Alhasan, Hend; Elmorsy, Sameh; Uetsuki, Keita; Onodera, Tomohiro; Takahata, Masahiko; Iwasaki, Norimasa

doi:10.1016/j.actbio.2019.03.028

Cited by 26 publications

(37 citation statements)

References 41 publications

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“…Mice were anesthetized with isoflurane inhalation and 100 μl antibody-diluted in PBS was subcutaneously injected onto the calvariae. For the XCL1-induced osteolysis model, collagen sponges of the single layer type (PELNAC, Tokyo, Japan) were soaked in 1 or 2 μg of recombinant mouse XCL1 (R&D system) or PBS ( n = 6 for each group) and transplanted subcutaneously onto the calvariae for 7 days ( 13 ). All procedures for animal experiments were approved by the Institute of Animal Care and Use Committee of the Hokkaido University Graduate School of Medicine (no.…”

Section: Methodsmentioning

confidence: 99%

“…Procedures for the debris-induced osteolysis model were performed as described previously (13). Briefly, 8-weeks old male C57B/6 SPF (CLEA, Tokyo, Japan) mice were injected intraperitoneally with 100 and 10 mg/kg of ketamine and xylazine, respectively, for anesthetization.…”

Section: Murine Calvarial Osteolysis Modelmentioning

confidence: 99%

“…The mice were sacrificed after 7 days and their calvariae were subjected to R-mCT2 scan analysis (Rigaku, Tokyo, Japan) for micro-computed tomography assessment (micro-CT). Bone loss on the bone surface were quantified as the percentage of bone loss surface/total area of interest using Bone J (National Institutes of Health, Washington, DC, USA) (13,14). For conducting the histological examination, 10% of formalin-fixed calvariae were decalcified in the Decalcifying Solution B (FUJIFILM Wako Pure Chemical Corporation, Osaka, Japan) for 3 days and then embedded in paraffin.…”

Section: Micro-ct Analysis and Bone Histomorphometrymentioning

confidence: 99%

“…The osteoclasts were differentiated and cultured as described previously (13). Briefly, human primary monocytes were separated from the blood samples of healthy donors by density gradient centrifugation (Ficoll-PaqueTM PLUS: GE Healthcare, Waukesha, WI, USA) followed by treatment with a MACS Pan monocyte isolation kit (Miltenyi Biotec, Auburn, CA, USA).…”

Section: Osteoclast Differentiation and Bone Resorption Assaysmentioning

confidence: 99%

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Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles

et al. 2020

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Tian et al. XCL1/Lymphotactin in Periprosthetic Osteolysis inflammatory and osteoclastogenic factors, including IL-6, IL-8, and RANKL in human differentiated osteoblasts. Together, these results suggested the potential role of XCL1 in the pathogenesis of periprosthetic osteolysis and aseptic loosening. Our data broaden knowledge of the pathogenesis of aseptic prosthesis loosening and highlight a novel molecular target for therapeutic intervention.

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Section: Methodsmentioning

confidence: 99%

Section: Murine Calvarial Osteolysis Modelmentioning

confidence: 99%

Section: Micro-ct Analysis and Bone Histomorphometrymentioning

confidence: 99%

Section: Osteoclast Differentiation and Bone Resorption Assaysmentioning

confidence: 99%

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Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles

et al. 2020

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“…But, as noted, for example, in Scemama et al (2017), long-term observations are still required to guarantee that reduction of XLPE wear will lead to a decrease in the number of cases of osteolysis, leading to aseptic loosening of total hip joint stems. Nevertheless, this direction of total hip joint improving in the scientific environment is considered to be very promising and many studies devoted to it have been carried out recently by various scientific groups (Galliera et al, 2018;Lambert et al, 2019;Massaccesi et al, 2019;Oral et al, 2019;Terkawi et al, 2019;Xu J.-Z. et al, 2019).…”

Section: Improvement Of Materials For Artificial Hip Joint Friction Cmentioning

confidence: 99%

Current Trends in Improving of Artificial Joints Design and Technologies for Their Arthroplasty

2020

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There is a global tendency to rejuvenate joint diseases, and serious diseases such as arthrosis and arthritis develop in 90% of people over 55 years of age. They are accompanied by degradation of cartilage, joint deformities and persistent pain, which leads to limited mobility and a significant deterioration in the quality of life of patients. For the treatment of these diseases in the late stages, depending on the indications, various methods are used, the most radical of which are methods of joint arthroplasty and, in particular, total arthroplasty. Currently, total arthroplasty is one of the most effective and high-quality surgical operations at the relevant medical indications. However, complications may also arise after it, leading, inter alia, to the need for repeated surgical intervention. In order to minimize the likelihood of complications, the artificial joints used in total arthroplasty and the technology of their fabrication are constantly being improved, which leads to the emergence of new designs and methods for their integration with living tissues. At the same time, at the moment, the improvement of traditional designs and production technologies has almost reached the top of their art, and their further improvements can be insignificantly or are associated with the use of the most up-today technologies, allowing for friction couples with low tribological properties to provide for them high ones, for example, gradient increase hardness in the couple titanium alloy on titanium alloy. This paper presents the current state of traditional technical means and technologies for joint arthroplasty. The main attention is paid to the analysis of the latest technologies in the field of joint arthroplasty, such as osseointegration of artificial joints, the improvement of materials with the property of osteoimmunomodulation, the improvement of joint arthroplasty technologies based on the modeling of dynamic osteosynthesis, as well as the identification of possible unconventional designs of artificial joints that contribute to these technologies, predictive assessment of areas for technologies improvement.

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Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis

Matsumae

Shimizu

Tian

et al. 2021

Bioengineering & Transla Med

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Identification of IL-27 as potent regulator of inflammatory osteolysis associated with vitamin E-blended ultra-high molecular weight polyethylene debris of orthopedic implants

Cited by 26 publications

References 41 publications

Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles

Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles

Current Trends in Improving of Artificial Joints Design and Technologies for Their Arthroplasty

Targeting thymidine phosphorylase as a potential therapy for bone loss associated with periprosthetic osteolysis

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