Identification of lymphatic pathway involved in the spreading of prostate cancer by fluorescence navigation approach with intraoperatively injected indocyanine green

Inoue, Shogo; Shiina, Hìroaki; Arichi, Naoko; Mitsui, Yozo; Hiraoka, Takeo; Wake, Koji; Sumura, Masahiro; Honda, Satoshi; Yanagimoto, Hiroaki; Urakami, Shinji; Matsubara, Akio; Igawa, Mikio

doi:10.5489/cuaj.10159

Cited by 34 publications

(32 citation statements)

References 13 publications

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“…The clinical superiority of the FN system to the RI-assisted one is due to the ease of tracking the lymphatic vessels into the pelvic LNs under FN guidance. 9 The results we obtained showed that the intensity of ICG fluorescence either in vivo or ex vivo was the strongest in the internal iliac region, second strongest in the obturator region, and weakest in the external iliac region. These results indicate that the major lymphatic channels involved in the spread of bladder cancer are those along the inferior vesical artery to the internal iliac artery.…”

Section: Discussionmentioning

confidence: 58%

“…7 We previously found that use of a fluorescence navigation (FN) system with ICG injection was safe and convenient in determining the border between normal and malignant kidney tissues during partial nephrectomy 8 and in identifying lymphatic vessels draining from the prostate; these findings validated the concept of SLNs in prostate cancer. 9 However, to the best of our knowledge, there are no reports on the use of ICG fluorescence navigation for SLN mapping in bladder cancer patients. …”

Section: Introductionmentioning

confidence: 99%

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Identification of lymphatic pathway involved in the spread of bladder cancer: Evidence obtained from fluorescence navigation with intraoperatively injected indocyanine green

Inoue

Shiina

Mitsui

et al. 2013

CUAJ

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E322Cite as: Can Urol Assoc J 2013;7(5-6):e322-8. http://dx.doi.org/10.5489/cuaj.12096 Published online May 13, 2013 (early released September 10, 2012). AbstractIntroduction: We identify lymphatic vessels draining from the bladder by using fluorescence navigation (FN) system. Methods: In total, 12 candidates for radical cystectomy and pelvic lymph node dissection (PLND) were included in this study. After an indocyanine green (ICG) solution was injected into the bladder during radical cystectomy, lymphatic vessels draining from the bladder were analyzed using a FN system. PLND was based on the lymphatic mapping created from the FN measurements (in vivo probing) in the external iliac, obturator and internal iliac regions; after PLND, the fluorescence of the removed lymph nodes (LNs) was analyzed on the bench (ex vivo probing). Results: There were no patients with complications associated with the intravesical ICG injection. A lymphatic pathway along inferior vesical vessels to internal iliac LNs was clearly illustrated in 7 cases. Under in-vivo probing, the fluorescence intensity of internal iliac nodes was greater than that of external iliac or obturator nodes. Under ex-vivo probing, the fluorescence intensity of internal iliac and obturator nodes was greater than that of external iliac nodes. Conclusions: Using an FN system after injecting ICG during a radical cystectomy operation is a safe and rational approach to detecting the lymphatic channel draining from the bladder. IntroductionThe sentinel lymph node (SLN) is the first lymph node (LN) through which cancer cells are detected from the primary site. The SLN concept is based on the hypothesis that secondary cancer cells are not found in LNs downstream from the first one receiving drainage from the primary tumour. The validity of this concept is well-established in breast and skin cancers, 1,2 and it has also been applied to penile cancer by Cabanas.3 Liedberg and colleagues reported the possibility of applying the SLN concept to bladder cancer using γ probe-guided SLN dissection, 4 but their approach combining preoperative lymphoscintigraphy with an intraoperative γ probe is complicated. Until now, two approaches have been used to identify SLNs: the dye-guided approach and the radioisotope-guided (RI-guided) approach. The dyeguided approach appears to be convenient and safe, but it sometimes cannot precisely detect SLNs deep in the pelvis, because the contrast of the target tissue is insufficient. The radioisotope-guided (RI-guided) approach can accurately determine the location of deep SLNs, but cannot identify minute lymphatic vessels. 5To identify the SLN and confirm the applicability of the SLN concept to bladder cancer, we need an anatomical understanding of the lymphatic network and flow around the bladder. The primary contributions to the knowledge of bladder lymphatics have come from European sources and were well-summarized by Leadbetter and Cooper. 6 Normal vesical lymphatics drain into the perivesical network, from which originate 6 groups of p...

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Identification of lymphatic pathway involved in the spread of bladder cancer: Evidence obtained from fluorescence navigation with intraoperatively injected indocyanine green

Inoue

Shiina

Mitsui

et al. 2013

CUAJ

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“…In its current form however, SLNB lacks not only the support of large, multi-centre studies but, like its predecessors in penile and pelvic malignancy, continues to be plagued by concerns around high false negative rates. With the investigation to T1 weighted MR, identifying all six cervical nodes, compared to just four [48] . The first use of NIRF in urogenital malignancy was in 2011, when lymphatic pathways in prostate cancer were mapped with indocyanine [49] .…”

Section: Resultsmentioning

confidence: 99%

Sentinel lymph node biopsy in renal malignancy: The past, present and future

Mahesan

Coscione

Ayres

et al. 2016

WJN

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Sentinel lymph node biopsy (SLNB) is now an established technique in penile and pelvic cancers, resulting in a lower mortality and morbidity when compared with the traditional lymph node dissection. In renal cancer however, despite some early successes for the SLNB technique, paucity of data remains a problem, thus lymph node dissection and extended lymph node dissection remain the management of choice in clinically node positive patients, with surveillance of lymph nodes in those who are clinically node negative. SLNB is a rapidly evolving technique and the introduction of new techniques such as near infra-red fluorescence optical imaging agents and positron emission tomography/computed tomography scans, may improve sensitivity. Evidence in support of this has already been recorded in bladder and prostate cancer. Although the lack of large multi-centre studies and issues around false negativity currently prevent its widespread use, with evolving techniques improving accuracy and the support of large-scale studies, SLNB does have the potential to become an integral part of staging in renal malignancy.

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“…Les ganglions inguinaux ont été considérés comme bénins, ne correspondant pas au territoire de drainage du cancer de prostate [14,15]. Pour les patients avec preuve histologique prostatique (biopsie ou exérèse chirurgicale), la concordance avec les images TEP a été évaluée en comparaison avec le compte rendu histologique détaillé.…”

Section: Gold Standard Et Analyse Statistiqueunclassified

Évaluation du statut ganglionnaire et prostatique à la phase dynamique précoce de la TEP à la 18F-choline dans le cancer de prostate

Mathieu¹,

Ferrer

Carlier

et al. 2015

Médecine Nucléaire

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Identification of lymphatic pathway involved in the spreading of prostate cancer by fluorescence navigation approach with intraoperatively injected indocyanine green

Cited by 34 publications

References 13 publications

Identification of lymphatic pathway involved in the spread of bladder cancer: Evidence obtained from fluorescence navigation with intraoperatively injected indocyanine green

Identification of lymphatic pathway involved in the spread of bladder cancer: Evidence obtained from fluorescence navigation with intraoperatively injected indocyanine green

Sentinel lymph node biopsy in renal malignancy: The past, present and future

Évaluation du statut ganglionnaire et prostatique à la phase dynamique précoce de la TEP à la 18F-choline dans le cancer de prostate

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