Identification of molecular network of gut‐brain axis associated with neuroprotective effects of PPARδ‐ligand erucic acid in rotenone‐induced Parkinson's disease model in zebrafish

Ünal, İsmail; Cansız, Derya; Sürmen, Mustafa Gani; Sürmen, Saime; Sezer, Zehra; Beler, Merih; Üstündağ, Ünsal Veli; Güzel, Elif; Alturfan, A. Ata; Emekli-Alturfan, Ebru

doi:10.1111/ejn.15904

Cited by 11 publications

(3 citation statements)

References 76 publications

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“…[5,12] The effects of erucic acid as a peroxisome proliferator-activated receptor delta (PPAR-δ) ligand have been investigated in rotenone-induced PD model in zebrafish. [13] Erucic acid mediated modulation of membrane composition is associated with complex changes in lipid homeostasis that may affect amyloidogenic processing, providing an important target for lipid-based AD therapies. [14] Thus, we proposed that erucic acid might lessen cognitive impairment and may be useful for treating AD.…”

Section: Introductionmentioning

confidence: 99%

Erucic acid ameliorates the lipopolysaccharide‐induced memory deficit in rats through inhibited inflammation cytokines expression/caspase 3/NF‐κB pathways

Sayyed

Hafeez

Al‐Abbasi

et al. 2023

Euro J Lipid Sci & Tech

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Erucic acid is a single unsaturated fatty acid that falls under the omega‐9 fatty acid family. It was suggested to treat Wistar rats with lipopolysaccharide (LPS)‐induced memory impairment and minimize cognitive impairment. A total of 30 animals were randomized: group I was normally treated group, group II was administered with LPS, group III was treated with LPS along with erucic acid at the dose of 10 mg kg–1 p.o.–1, group IV was treated with LPS along with erucic acid at 20 mg kg–1 p.o.–1 and group V was the erucic acid per se group provided at the dose of 20 mg kg–1 p.o.–1 per se. Behavioral tests were evaluated by using the Morris water maze and Y‐maze. Biochemical analysis including acetylcholine esterase (AChE), choline acetyltransferase (ChAT), glutathione (GSH), catalase activity (CAT), superoxide dismutase (SOD), and nitric oxide (NO) along with proinflammatory mediators tumor necrosis factor‐α (TNF‐α), interleukin‐1β (IL‐1β), caspase 3, and neuroinflammatory biomarker (nuclear factor kappa B‐NF‐κB) were measured. Erucic acid produced substantial behavioral improvement in the Y‐maze test, including spontaneous alterations and reduced latency time during acquisition, and a longer duration of time in the consolidation phase undergoing the MWM test. Furthermore, erucic acid improved the AChE, proinflammatory markers, and oxidative stress as well as restoring endogenous antioxidant levels, ChAT, caspase 3, and NF‐κB levels. Erucic acid may be a therapeutic component for conditions related to memory disorders such as memory impairment, enhances memory functioning, and protects against neuronal damage.

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Section: Introductionmentioning

confidence: 99%

Erucic acid ameliorates the lipopolysaccharide‐induced memory deficit in rats through inhibited inflammation cytokines expression/caspase 3/NF‐κB pathways

Sayyed

Hafeez

Al‐Abbasi

et al. 2023

Euro J Lipid Sci & Tech

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“…Additionally, co-administration of EA and rotenone caused a significant increase in acetylcholinesterase activity in the brain and intestines, when compared to the rotenone group. Although further studies are needed in other animal PD models, the results presented seem to be in perspective [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties

et al. 2023

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Erucic acid (EA) is monounsaturated fatty acid (22:1 n-9), synthesized in the seeds of many plants from the Brassicaceae family, with Brassica napus, B. rapa, or B. carinata considered as its richest source. As the compound has been blamed for the poisoning effect in Toxic Oil Syndrome, and some data indicated its cardiotoxicity to rats, EA has been for decades classified as toxic substance, the use of which should be avoided. However, the cardiac adverse effects of EA have not been confirmed in humans, and the experiments in animal models had many limitations. Thus, the aim of this review was to present the results of the so far published studies on both toxic, and pharmacological properties of EA, trying to answer the question on its future medicinal use. Despite the ambiguous and relatively small data on toxic and beneficial effects of EA it seems that the compound is worth investigating. Further research should be particularly directed at the verification EA toxicity, more in-depth studies on its neuroprotective and cytotoxic properties, but also its use in combination with other drugs, as well as its role as a drug carrier.

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“…The mono-unsaturated omega-9 fatty acid erucic acid (3 mg/kg) enhanced cognitive performance in drug-naïve mice and ameliorated scopolamine-induced memory impairments associated with increased phosphorylation of poly-phosphatidylinositide 3-kinase (PI3K), protein kinase C-zeta, extracellular signal-regulated kinase, cAMP-response element-binding protein, and additional protein kinase B in the hippocampus ( Kim and Al, 2016 ). Erucic acid showed protective effects in the brain and the intestines of a rotenone-treated zebrafish model of Parkinson’s disease and improved activity levels ( Ünal and Al, 2022 ). Other beneficial effects of erucic acid include antibacterial and antiviral activities, as well as cytotoxic anticancer activity ( Galanthy et al, 2023 ).…”

Section: Discussionmentioning

confidence: 99%

Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats

Raber,

Holden,

Kessler

et al. 2024

Front. Physiol.

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Introduction: The space environment astronauts experience during space missions consists of multiple environmental challenges, including microgravity. In this study, we assessed the behavioral and cognitive performances of male Fisher rats 2 months after sham irradiation or total body irradiation with photons in the absence or presence of simulated microgravity. We analyzed the plasma collected 9 months after sham irradiation or total body irradiation for distinct alterations in metabolic pathways and to determine whether changes to metabolic measures were associated with specific behavioral and cognitive measures.Methods: A total of 344 male Fischer rats were irradiated with photons (6 MeV; 3, 8, or 10 Gy) in the absence or presence of simulated weightlessness achieved using hindlimb unloading (HU). To identify potential plasma biomarkers of photon radiation exposure or the HU condition for behavioral or cognitive performance, we performed regression analyses.Results: The behavioral effects of HU on activity levels in an open field, measures of anxiety in an elevated plus maze, and anhedonia in the M&M consumption test were more pronounced than those of photon irradiation. Phenylalanine, tyrosine, and tryptophan metabolism, and phenylalanine metabolism and biosynthesis showed very strong pathway changes, following photon irradiation and HU in animals irradiated with 3 Gy. Here, 29 out of 101 plasma metabolites were associated with 1 out of 13 behavioral measures. In the absence of HU, 22 metabolites were related to behavioral and cognitive measures. In HU animals that were sham-irradiated or irradiated with 8 Gy, one metabolite was related to behavioral and cognitive measures. In HU animals irradiated with 3 Gy, six metabolites were related to behavioral and cognitive measures.Discussion: These data suggest that it will be possible to develop stable plasma biomarkers of behavioral and cognitive performance, following environmental challenges like HU and radiation exposure.

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Identification of molecular network of gut‐brain axis associated with neuroprotective effects of PPARδ‐ligand erucic acid in rotenone‐induced Parkinson's disease model in zebrafish

Cited by 11 publications

References 76 publications

Erucic acid ameliorates the lipopolysaccharide‐induced memory deficit in rats through inhibited inflammation cytokines expression/caspase 3/NF‐κB pathways

Erucic acid ameliorates the lipopolysaccharide‐induced memory deficit in rats through inhibited inflammation cytokines expression/caspase 3/NF‐κB pathways

Erucic Acid—Both Sides of the Story: A Concise Review on Its Beneficial and Toxic Properties

Effects of photon irradiation in the presence and absence of hindlimb unloading on the behavioral performance and metabolic pathways in the plasma of Fischer rats

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