Identification of mycotoxins by UHPLC–QTOF MS in airborne fungi and fungi isolated from industrial paper and antique documents from the Archive of Bogotá

Castillo, Nancy I.; Ibáñez, María; Beltrán, Eduardo; Rivera‐Monroy, Jhon; Ochoa, José Boix; Páez-Castillo, Mónica; Posada-Buitrago, Martha Lucia; Sulyok, Michael; Hernández, Félix

doi:10.1016/j.envres.2015.10.031

Cited by 17 publications

(10 citation statements)

References 53 publications

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“…Additionally, they can persist and accumulate in organisms when the exposure is chronic [ 30 ]. Castillo et al (2016) reports that there are approximately 600 mycotoxins, with new toxins still being discovered, which brings additional concerns and implications to food safety [ 31 ]. It is difficult to assess the impact of mycotoxins; still, it is believed that 25% of the world’s agricultural commodities are contaminated [ 32 ].…”

Section: The Problem Of Fungal Contaminationmentioning

confidence: 99%

The Potential of Fatty Acids and Their Derivatives as Antifungal Agents: A Review

Guimarães

Venâncio

2022

Toxins

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Fungal contamination presents several problems: in humans, health issues arise from infections with opportunistic filamentous fungi and yeast, while in food, fungi cause spoilage and, in particular, in the case of mycotoxigenic fungi, can cause serious health issues. Several types of fatty acids and their derivatives, oxylipins, have been found to have inhibitory effect towards fungal growth and the production of mycotoxins. The use of fatty acids as antifungals could fulfil consumer’s requests of more natural and environmentally friendly compounds, while being less likely to promote fungal resistance. In addition, due to their nature, fatty acids are easily used as food additives. In this work, we review the most relevant and recent studies on the antifungal ability of fatty acids. We focused on saturated fatty acids, unsaturated fatty acids, and oxylipins, their different impact on fungal inhibition, their proposed modes of action, and their ability to impair mycotoxin production. Applications of fatty acids as antifungals and their limitations are also addressed.

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Section: The Problem Of Fungal Contaminationmentioning

confidence: 99%

The Potential of Fatty Acids and Their Derivatives as Antifungal Agents: A Review

Guimarães

Venâncio

2022

Toxins

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“…Along with penicillin, 6-MSA, yanuthone D, and the pigments sorbicillin and chrysogenin (commented in previous sections), P. chrysogenum also produces mycotoxins such as roquefortine C, andrastin A, and PR-toxin. These mycotoxins are usually found in environments from which P. chrysogenum strains are isolated, e.g., paper from antique documents in historical archives [ 236 ]. Roquefortine C is the trademark metabolite of the blue cheese fungus P. roqueforti .…”

Section: Treasure Islandmentioning

confidence: 99%

Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology

et al. 2022

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The discovery of penicillin entailed a decisive breakthrough in medicine. No other medical advance has ever had the same impact in the clinical practise. The fungus Penicillium chrysogenum (reclassified as P. rubens) has been used for industrial production of penicillin ever since the forties of the past century; industrial biotechnology developed hand in hand with it, and currently P. chrysogenum is a thoroughly studied model for secondary metabolite production and regulation. In addition to its role as penicillin producer, recent synthetic biology advances have put P. chrysogenum on the path to become a cell factory for the production of metabolites with biotechnological interest. In this review, we tell the history of P. chrysogenum, from the discovery of penicillin and the first isolation of strains with high production capacity to the most recent research advances with the fungus. We will describe how classical strain improvement programs achieved the goal of increasing production and how the development of different molecular tools allowed further improvements. The discovery of the penicillin gene cluster, the origin of the penicillin genes, the regulation of penicillin production, and a compilation of other P. chrysogenum secondary metabolites will also be covered and updated in this work.

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“…Searching for common fragments is a powerful strategy, able to detect and tentatively identify TPs/metabolites in the samples, although it is time-consuming and requires a notable knowledge of mass fragmentation rules. This approach benefits when all-ion-fragmentation (AIF) acquisitions (also known as MS E , all ion or broad-band CID) are performed during HRMS screening (Castillo et al, 2016;G omez Ramos et al, 2019;Hu et al, 2017;Kinyua et al, 2015;Telving et al, 2016). This allows to obtain simultaneous information on intact molecules (low collision energy, LE) as well as their fragments (high collision energy, HE) without precursor ion selection.…”

Section: Relevance Of Transformation Productsmentioning

confidence: 99%

The role of analytical chemistry in exposure science: Focus on the aquatic environment

et al. 2019

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h i g h l i g h t s The role of modern analytical chemistry is essential in exposure science. Hyphenation of chromatography and HRMS allows the identification of many organic contaminants in the aquatic environment. Different strategies (target, suspect, non-target) are used for the broad investigation of emerging chemical risks in water. Monitoring programs and risks assessments are normally focused on parent contaminants. Little information exists on occurrence and (eco)toxicological effects of transformation products/metabolites in water.

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Identification of mycotoxins by UHPLC–QTOF MS in airborne fungi and fungi isolated from industrial paper and antique documents from the Archive of Bogotá

Cited by 17 publications

References 53 publications

The Potential of Fatty Acids and Their Derivatives as Antifungal Agents: A Review

The Potential of Fatty Acids and Their Derivatives as Antifungal Agents: A Review

Penicillium chrysogenum, a Vintage Model with a Cutting-Edge Profile in Biotechnology

The role of analytical chemistry in exposure science: Focus on the aquatic environment

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