Identification of new biologically active synthetic molecules: comparative experimental and theoretical studies on the structure-antioxidant activity relationship of cyclic 1,3-ketoamides

Kerbadou, Riad Mustapha; Aoul, Ratiba Hadjadj; Benmaati, Aouicha; Taleb, Assya; Hacini, Salih; Zahmani, Hadjira Habib

doi:10.1007/s00894-021-04705-4

Cited by 4 publications

(4 citation statements)

References 58 publications

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“…The antioxidant activity of different nanocomposites as well as G3 dendrimer was evaluated using the DPPH radical scavenging test following the previous study of Kerbadou et al 77 The ascorbic acid was taken as a reference during this study. First, the electron transfers of the DPPH dissolved in a concentrated methanol solution produce a mauve colour.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…Then, the DPPH solution is mixed with the antioxidant compound which can give a hydrogen atom and leads to the reduced form, a change of colour will be observed from the mauve colour to yellow, this is due to the radical-scavenging capacity of the molecule tested (Scheme 2). 77 All tests were performed three times. The DPPH solution and the tested samples of dendrimers with different concentrations (10-800 μg mL À1 ) were freshly prepared with an alcoholic solution.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

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Classical and ultrasonic preparation of new dendrimer–Copper nanocomposites: Application in the catalytic reduction, antioxidant, and antimicrobial activities

Zaoui

Daouadji

Beldjilali

et al. 2023

Applied Organom Chemis

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A new dendrimer based on citric acid and sebacoyl chloride was synthesized by Steglich esterification. The obtained dendrimer was used as a matrix for the dispersion of copper nanoparticles using classical and ultrasound methods. All materials were characterized by FTIR, 1H NMR, thermogravimetric analysis, X-ray photoelectron spectrometry, scanning electron microscopy, and energ-ydispersive -X-ray spectroscopy. The obtained nanocomposites were tested against two Gram-positive pathogenic bacteria (Bacillus cereus and Staphylococcus aureus), two Gram negative (Escherichia coli and Pseudomonas aeruginosa), the organic dye methylene blue, and in the 1,1-diphenyl-2-picrylhydrazile radical scavenging assay. A comparative study between both methods in structural, morphological, and thermal properties as well as in the antimicrobial, antioxidant, and catalytic reduction activities was provided. All nanocomposites showed an excellent activity for all applications. The comparison between both synthesis methods shows the superiority of the sonication methods, especially via the catalytic reduction and the antioxidant activities, the classic method allows better thermal stability and a higher metal content with some cationic oxidation state in the obtained nanocomposites, but ultrasound allows a better dispersion with a fully reduced metal.

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Section: Antioxidant Activitymentioning

confidence: 99%

Section: Antioxidant Activitymentioning

confidence: 99%

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Classical and ultrasonic preparation of new dendrimer–Copper nanocomposites: Application in the catalytic reduction, antioxidant, and antimicrobial activities

Zaoui

Daouadji

Beldjilali

et al. 2023

Applied Organom Chemis

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show abstract

“…In application, it is used to investigate the structural, electronic, and physical properties of the molecules and materials, such as the binding energies of the molecules in chemistry, physics, and other areas [ [19]]. For example, DFT aims to calculate the electronic ground state energy of a system of N electrons only through its density without prior well-known system wave function [11,17,18,[20][21][22][23].…”

Section: ■ Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Theoretical Study of Some New Organotellurium Compounds Derived from Camphor

Al-Saadawy

2022

Indones. J. Chem.

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The present work describes the synthesis of a variety of organotellurium compounds. The first part describes the synthesis of a new series of organotellurium compounds containing azomethine groups. Reaction of (E)-(4-((1,7,7-trimethyl bicyclo[2.2.1]heptan-2-ylidene)amino)phenyl)mercury(II)chloride and (E)-(5-methyl-2-((1,7,7-trimethylbicyclo[2.2.1]heptan-2-ylidene)amino)phenyl) mercury(II)chloride with tellurium tetrabromide in 2:1 mole ratio yielded the tellurated Schiff bases Ar2TeBr2 (where Ar = 1-(C9H16C=N)C=N)C6H4 and 1-(C9H16C=N)C=N)-4-CH3C6H3) respectively. Reduction of organyl tellurium dibromide Ar2TeBr2 by hydrazine hydrate obtained the corresponding tellurides (i.e., Ar2Te) in good yields. Characterization of the prepared compounds was carried out using infrared spectrum (FT-IR), proton nuclear magnetic resonance spectrum (1H-NMR), and elemental analysis (CHN). The molecular structure of the organotellurium compounds was investigated using the density functional theory with hybrid functional (B3LYP), and the basis set 6-31G Geometrical structure, HOMO surfaces, LUMO surfaces, and energy gap have been produced throughout the geometry optimization. The molecular geometry and contours for the organotellurium compounds were investigated throughout the geometrical optimization. The donor and acceptor properties have been studied by comparing organotellurium compounds' highest occupied molecular orbital energies (HOMO). The present study aims to prepare organotellurium compounds derived from aniline, p-toluidine, and camphor and their derivatives using tellurated Schiff bases.

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Improving the antioxidant activity of natural antioxidant honokiol by introducing the amino group

Liu

Yang

et al. 2021

J Mol Model

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Identification of new biologically active synthetic molecules: comparative experimental and theoretical studies on the structure-antioxidant activity relationship of cyclic 1,3-ketoamides

Cited by 4 publications

References 58 publications

Classical and ultrasonic preparation of new dendrimer–Copper nanocomposites: Application in the catalytic reduction, antioxidant, and antimicrobial activities

Classical and ultrasonic preparation of new dendrimer–Copper nanocomposites: Application in the catalytic reduction, antioxidant, and antimicrobial activities

Synthesis, Characterization, and Theoretical Study of Some New Organotellurium Compounds Derived from Camphor

Improving the antioxidant activity of natural antioxidant honokiol by introducing the amino group

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