The Indonesian Agency for Agricultural Research and Development developed the Kampung Unggul Balitbangtan (KUB) Chicken, a superior breed of native chicken. The KUB chicken exhibited resistance to diseases, boasted lower mortality rates, and yielded more eggs compared to conventional free-range chickens. However, the KUB chickens were not immune to certain prevalent avian diseases, leading to substantial mortality and subsequent economic losses in Indonesia. This study, conducted from October to December 2021 in Central Java, aimed to determine the prevalence of various diseases in KUB chickens housed in farmer’s henhouse. Data were collected from 30 KUB chicken farmers. The results indicated the following prevalence rates for various infections: Snot at 44%, Coccidiosis at 9%, Salmonellosis at 9%, Infectious Bursal Disease at 9%, Newcastle Disease at 4%, and Helminthiosis at 4% across all sampled coops. Snot infection was notably higher in KUB Chickens, largely attributed to inadequate management, followed by Coccidiosis, Salmonellosis, and Infectious Bursal Disease. Clearly, disease prevalence in KUB chickens within a farmer’s coop can be mitigated by improved management practices and appropriate vaccination.