Identification of NKp80, a novel triggering molecule expressed by human NK cells

Vitale, Massimo; Falco, Michela; Castriconi, Roberta; Parolini, Silvia; Zambello, Renato; Semenzato, Gianpietro; Biassoni, Roberto; Bottino, Cristina; Moretta, Lorenzo

doi:10.1002/1521-4141(200101)31:1<233::aid-immu233>3.0.co;2-4

Cited by 186 publications

(126 citation statements)

References 39 publications

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“…The highest expressing specific gene in NK cells is KLRF1, a C-type lectin with immunoreceptor tyrosinebased inhibitory motifs (ITIM) motifs that stimulates cytolysis 28 as shown in Figure 3b. Its expression is highest in resting cells, and decreases upon activation.…”

Section: Nk Cellsmentioning

confidence: 99%

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

Abbas¹,

Baldwin²,

Ma³

et al. 2005

Genes Immun

364

356

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Immune cell-specific expression is one indication of the importance of a gene's role in the immune response. We have compiled a compendium of microarray expression data for virtually all human genes from six key immune cell types and their activated and differentiated states. Immune Response In Silico (IRIS) is a collection of genes that have been selected for specific expression in immune cells. The expression pattern of IRIS genes recapitulates the phylogeny of immune cells in terms of the lineages of their differentiation. Gene Ontology assignments for IRIS genes reveal significant involvement in inflammation and immunity. Genes encoding CD antigens, cytokines, integrins and many other gene families playing key roles in the immune response are highly represented. IRIS also includes proteins of unknown function and expressed sequence tags that may not represent genes. The predicted cellular localization of IRIS proteins is evenly distributed between cell surface and intracellular compartments, indicating that immune specificity is important at many points in the signaling pathways of the immune response. IRIS provides a resource for further investigation into the function of the immune system and immune diseases.

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Section: Nk Cellsmentioning

confidence: 99%

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

Abbas¹,

Baldwin²,

Ma³

et al. 2005

Genes Immun

364

356

View full text Add to dashboard Cite

show abstract

“…In redirected killing assay using monoclonal antibodies that initiate killing of Fc receptor-bearing tumor cell lines, NK cell surface molecules that have been implicated in cell activation include CD2, 104 CD16, 105 LFA-1, 106 CD40 ligand, 107 CD69, 108 2B4, [109][110][111] and NKp80. 112,113 These receptors, however, function as coreceptors in that their triggering function depends on the simultaneous ligation of main triggering receptors. For example, monoclonal antibody triggering via the 2B4 and NKp80 molecules induces strong cytolytic responses only in NKp46 bright NK cells but not in NKp46 dull cells, although the latter expressed comparable surface densities of 2B4 and NKp80.…”

Section: Other Membrane Receptors Implicated In Modulation Of Nk Cellmentioning

confidence: 99%

“…For example, monoclonal antibody triggering via the 2B4 and NKp80 molecules induces strong cytolytic responses only in NKp46 bright NK cells but not in NKp46 dull cells, although the latter expressed comparable surface densities of 2B4 and NKp80. 111,112 Therefore, these coreceptors only result in activation if a first signal has been provided by the main receptor. The relative roles of these coreceptors in NKmediated killing of tumor cells remains to be fully elucidated.…”

Section: Other Membrane Receptors Implicated In Modulation Of Nk Cellmentioning

confidence: 99%

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect

Farag

Fehniger

Ruggeri

et al. 2002

Blood

455

355

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“…Another triggering receptor, the NKG2D, is expressed by both NK cells and cytolytic T lymphocytes (11,12). The 2B4 surface molecule, mostly functioning as an activating coreceptor, is expressed by NK cells and by a subset of cytolytic T lymphocytes (13,14), whereas the NKp80, another recently identified coreceptor, is essentially confined to NK cells (15).…”

Section: N Atural Killer (Nk) Cells Are Capable Of Discriminating Betmentioning

confidence: 99%

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoingin vitrodifferentiation

Sivori

Falco

Marcenaro

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

179

172

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In this study we analyzed the progression of cell surface receptor expression during the in vitro-induced human natural killer (NK) cell maturation from CD34 ؉ Lin ؊ cell precursors. NKp46 and NKp30, two major triggering receptors that play a central role in natural cytotoxicity, were expressed before the HLA class I-specific inhibitory receptors. Moreover, their appearance at the cell surface correlated with the acquisition of cytolytic activity by developing NK cells. Although the early expression of triggering receptors may provide activating signals required for inducing further cell differentiation, it may also affect the self-tolerance of developing NK cells. Our data show that a fail-safe mechanism preventing killing of normal autologous cells may be provided by the 2B4 surface molecule, which, at early stages of NK cell differentiation, functions as an inhibitory rather than as an activating receptor.

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Identification of NKp80, a novel triggering molecule expressed by human NK cells

Cited by 186 publications

References 39 publications

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

Immune response in silico (IRIS): immune-specific genes identified from a compendium of microarray expression data

Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect

Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoingin vitrodifferentiation

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