Identification of non volatile migrant compounds and NIAS in polypropylene films used as food packaging characterized by UPLC-MS/QTOF

Vera, Paula; Canellas, Elena; Nerı́n, Cristina

doi:10.1016/j.talanta.2018.06.022

Cited by 81 publications

(38 citation statements)

References 36 publications

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“…Several lubricants were found in the samples, such as palmitic, stearic acid [33], ethyl palmitate [16], butyl palmitate [34], oleic acid, and glycerol tricaprylate [27]. Some compounds used in solvents for lacquers and adhesives were identified.…”

Section: Gc-ms Screeningmentioning

confidence: 99%

GC-MS Screening for the Identification of Potential Migrants Present in Polymeric Coatings of Food Cans

Lestido‐Cardama

Sendón

Bustos³

et al. 2019

Polymers

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The coatings used in cans can release complex chemical mixtures into foodstuffs. Therefore, it is important to develop analytical methods for the identification of these potential migrant compounds in packaged food to guarantee the compliance with European food packaging legislation and ensure consumer safety. In the present work, the type of coating in a total of twelve cans collected in Santiago de Compostela (Spain) were evaluated using an ATR (attenuated total reflectance)-FTIR spectrometer. These samples were analysed after extraction with acetonitrile in order to identify potential migrants through a screening method by gas chromatography coupled to mass spectrometry (GC-MS). A total of forty-seven volatile and semi-volatile compounds were identified in these samples, including plasticizers, photoinitiators, antioxidants, lubricants, etc. Then, in a second step, a targeted analysis was carried out for the simultaneous determination of 13 compounds, including bisphenols (BPA, BPB, BPC, BPE, BPF, BPG) and BADGEs (BADGE, BADGE.H 2 O, BADGE.2H 2 O, BADGE.HCl, BADGE.2HCl, BADGE.H 2 O.HCl, cyclo-di-BADGE) by liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) with atmospheric pressure chemical ionisation (APCI) source. Among all the bisphenols analysed, only the bisphenol A was detected in four samples; while cyclo-di-BADGE was the predominant compound detected in all the samples analysed.

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Section: Gc-ms Screeningmentioning

confidence: 99%

GC-MS Screening for the Identification of Potential Migrants Present in Polymeric Coatings of Food Cans

Lestido‐Cardama

Sendón

Bustos³

et al. 2019

Polymers

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“…It is known that ethoxylated aliphatic alkylamines are an important class of plastic antistatic agents . N,N ‐Bis(2‐hydroxyethyl) amines had been found in some polypropylene films used as food packaging . Xia et al have also identified an interference which was a sulfoxide oxidative product of didodecyl 3,3'‐thiodipropionate leached from polypropylene tubes .…”

Section: Resultsmentioning

confidence: 99%

“…[21][22][23] N,N-Bis(2-hydroxyethyl) amines had been found in some polypropylene films used as food packaging. 24 (absolute intensity 1E8) were detected in tubes from two suppliers but were not found in tubes from the other three suppliers. Then different solvents including acetonitrile, methanol and water were tested following the treatment used above.…”

Section: Source Of the Interferencesmentioning

confidence: 86%

Identification of new interferences leached from plastic microcentrifuge tubes in electrospray ionization mass spectrometry

Chai

Chen

Gao

et al. 2019

Rapid Comm Mass Spectrometry

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Rationale The incredible sensitivity of the modern mass spectrometry instrument enables scientists to detect a large number of molecules ranging from small organic compounds to biological macromolecules. However, the same sensitivity often throws up challenges with respect to background interferences and contaminants. The identification and source of these contaminants is very important for reducing background contamination and ensuring the accuracy of the analysis results. Methods The interfering compounds were analyzed by high‐performance liquid chromatography coupled with a hybrid quadrupole‐orbitrap mass spectrometer. The structural analysis was conducted by obtaining the accurate masses of precursors and their fragment ions. The retention time and MS/MS spectrum of one of the interfering compounds (N‐lauryldiethanolamine) were compared with an authentic standard to reach an unequivocal structural assignment. Results The interferences (m/z 274 and 318 in positive mode) were observed during the analysis of herbicides in tea samples by electrospray ionization mass spectrometry (ESI‐MS). Their structures were identified to be N‐lauryldiethanolamine and N‐(2‐hydroxyethyl)‐N‐(2‐(2‐hydroxyethoxy)ethyl)dodecylamine by fragmentation interpretation and further confirmed by a standard compound. These interferences were found to be leached from the plastic microcentrifuge tubes used during sample pretreatment. The plastic tubes from two of the five suppliers tested were found to contain these two interferences. Conclusions In this work, we presented an example about the observation, identification and source of interferences in ESI‐MS. The N‐lauryldiethanolamine and other ethoxylated aliphatic alkylamines are common plastic antistatic agents. They possess high proton affinity so that they show a strong response in ESI positive mode. In order to avoid their interference during mass spectrometric analysis we need to choose plastic tubes (or other plastic materials) that do not contain such antistatic agents.

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“…Ultra-high performance liquid chromatography coupled to quadrupole-time of flight mass spectrometry Elevated Energy (UPLC-Q-TOF-MS E ) is a very attractive tool for nontarget analysis of non-volatile compounds from complex samples, because the obtained precursor and fragment ions have high sensitivity, high resolution, and high mass accuracy. MS E is a patented acquisition mode, where low and high energy spectra are collected at the same time [27,69]. Figure 6 shows an example of spectra of ethoxytriethylene glycol methacrylate (ETMA), acquired using two different cone voltages (15 and 30 V) during the identification of non-volatile migrants from baby bottles by UPLC-Q-TOF-MS E [20].…”

Section: Non-volatile Compoundsmentioning

confidence: 99%

Analytical Approaches for Analysis of Safety of Modern Food Packaging: A Review

Wrona

Nerı́n

2020

Molecules

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Nowadays, food packaging is a crucial tool for preserving food quality and has become an inseparable part of our daily life. Strong consumer demand and market trends enforce more advanced and creative forms of food packaging. New packaging development requires safety evaluations that always implicate the application of complex analytical methods. The present work reviews the development and application of new analytical methods for detection of possible food contaminants from the packaging origin on the quality and safety of fresh food. Among food contaminants migrants, set-off migrants from printing inks, polymer degradation products, and aromatic volatile compounds can be found that may compromise the safety and organoleptic properties of food. The list of possible chemical migrants is very wide and includes antioxidants, antimicrobials, intentionally added substances (IAS), non-intentionally added substances (NIAS), monomers, oligomers, and nanoparticles. All this information collected prior to the analysis will influence the type of analyzing samples and molecules (analytes) and therefore the selection of a convenient analytical method. Different analytical strategies will be discussed, including techniques for direct polymer analysis.

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Identification of non volatile migrant compounds and NIAS in polypropylene films used as food packaging characterized by UPLC-MS/QTOF

Cited by 81 publications

References 36 publications

GC-MS Screening for the Identification of Potential Migrants Present in Polymeric Coatings of Food Cans

GC-MS Screening for the Identification of Potential Migrants Present in Polymeric Coatings of Food Cans

Identification of new interferences leached from plastic microcentrifuge tubes in electrospray ionization mass spectrometry

Analytical Approaches for Analysis of Safety of Modern Food Packaging: A Review

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