Identification of novel biomarkers of heavy ion exposure: Proteins, miRNAs and tRNA-derived fragments in serum

Bai, Hao; Zhang, Tongshan; Wang, Jufang; Hua, Junrui; Wei, Wenjun

doi:10.1016/j.actaastro.2021.05.047

Cited by 4 publications

(2 citation statements)

References 32 publications

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“…Proteins, microRNAs (miRNAs), and transfer ribonucleic acid (tRNA)-derived fragments in serum showed great potential as early biomarkers of exposure to energetic heavy ions and might be helpful in dose reconstruction and risk assessment of heavy-ion exposure in deep space exploration ( 64 ). These biomarkers increase or decrease with the increase of the dose in the range of 10–50 cGy.…”

Section: Resultsmentioning

confidence: 99%

Dose-Effects Models for Space Radiobiology: An Overview on Dose-Effect Relationships

Strigari

Strolin

Morganti

et al. 2021

Front. Public Health

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Space radiobiology is an interdisciplinary science that examines the biological effects of ionizing radiation on humans involved in aerospace missions. The dose-effect models are one of the relevant topics of space radiobiology. Their knowledge is crucial for optimizing radioprotection strategies (e.g., spaceship and lunar space station-shielding and lunar/Mars village design), the risk assessment of the health hazard related to human space exploration, and reducing damages induced to astronauts from galactic cosmic radiation. Dose-effect relationships describe the observed damages to normal tissues or cancer induction during and after space flights. They are developed for the various dose ranges and radiation qualities characterizing the actual and the forecast space missions [International Space Station (ISS) and solar system exploration]. Based on a Pubmed search including 53 papers reporting the collected dose-effect relationships after space missions or in ground simulations, 7 significant dose-effect relationships (e.g., eye flashes, cataract, central nervous systems, cardiovascular disease, cancer, chromosomal aberrations, and biomarkers) have been identified. For each considered effect, the absorbed dose thresholds and the uncertainties/limitations of the developed relationships are summarized and discussed. The current knowledge on this topic can benefit from further in vitro and in vivo radiobiological studies, an accurate characterization of the quality of space radiation, and the numerous experimental dose-effects data derived from the experience in the clinical use of ionizing radiation for diagnostic or treatments with doses similar to those foreseen for the future space missions. The growing number of pooled studies could improve the prediction ability of dose-effect relationships for space exposure and reduce their uncertainty level. Novel research in the field is of paramount importance to reduce damages to astronauts from cosmic radiation before Beyond Low Earth Orbit exploration in the next future. The study aims at providing an overview of the published dose-effect relationships and illustrates novel perspectives to inspire future research.

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Section: Resultsmentioning

confidence: 99%

Dose-Effects Models for Space Radiobiology: An Overview on Dose-Effect Relationships

Strigari

Strolin

Morganti

et al. 2021

Front. Public Health

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“…And they might be used for dose reconstruction and risk assessment of heavy ion exposure in deep space exploration. 16 Circulating miRNAs reflect the impact of ionizing radiation irrespective of some different species, often in a dose-dependent manner. 17 In brief, these results make miRNAs promising biomarkers of radiation exposure.…”

Section: Introductionmentioning

confidence: 99%

Screening of miRNAs in White Blood Cell as a Radiation Biomarkers for Rapid Assessment of Acute Radiation Injury

Li¹,

Shen²,

Chen³

et al. 2022

Dose-Response

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Accidental radiation exposure is a threat to human health that necessitates effective clinical diagnosis. Suitable biomarkers are urgently needed for early assessment of exposure dose. Existing technologies being used to assess the extent of radiation have notable limitations. As a radiation biomarker, miRNA has the advantages of simple detection and high throughput. In this study, we screened for miRNAs with dose and time dependent responses in peripheral blood leukocytes via miRNA sequencing in establishing the animal model of acute radiation injury. Four radiation-sensitive and stably expressed miRNAs were selected out in the 24 h group of leukocyte miRNAs: mmu-miR-130b-5p, mmu-miR-148b-5p, mmu-miR-184-3p, mmu-miR-26a-2-3p, and five were screened in the 48 h group of leukocyte miRNAs: mmu-miR-130b-5p, mmu-miR-423-5p, mmu-miR-676-3p, mmu-miR-150-5p, mmu-miR-342-3p.The correlation curves between their expression and irradiation dose were plotted. Then, the results were validated by RT-qPCR in mouse peripheral blood. As a result, mmu-miR-150-5p and mmu-miR-342-3p showed the highest correlation at 48h after irradiation, and mmu-miR-130b-5p showed good correlation at both 24 h and 48 h after irradiation. In a conclusion, the miRNAs that are sensitive to ionizing radiation with dose dependent effects were selected out, which have the potential of forming a rapid assessment scheme for acute radiation injury.

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Microfluidic chip-based long-term preservation and culture of engineering bacteria for DNA damage evaluation

Wang

et al. 2022

Appl Microbiol Biotechnol

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Identification of novel biomarkers of heavy ion exposure: Proteins, miRNAs and tRNA-derived fragments in serum

Cited by 4 publications

References 32 publications

Dose-Effects Models for Space Radiobiology: An Overview on Dose-Effect Relationships

Dose-Effects Models for Space Radiobiology: An Overview on Dose-Effect Relationships

Screening of miRNAs in White Blood Cell as a Radiation Biomarkers for Rapid Assessment of Acute Radiation Injury

Microfluidic chip-based long-term preservation and culture of engineering bacteria for DNA damage evaluation

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