Identification of novel dioxin-responsive genes by representational difference analysis

Rivera, Steven; Saarikoski, Sirkku T.; Sun, Weimin; Hankinson, Oliver

doi:10.1080/00498250601169816

Cited by 11 publications

(5 citation statements)

References 32 publications

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“…40 In the clinical setting, the levels of TNFa and IL-1b are known to be elevated in nasopharyngeal carcinoma. 6,7,41 Thus, the dysregulation of TNFAIP2 expression in the nasopharyngeal carcinoma microenvironment may result from the combined effects of TNFa and IL-1b, which may promote tumor progression (eg, distant metastasis and angiogenesis) by inducing TNFAIP2.…”

Section: Discussionmentioning

confidence: 99%

A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma

Chen

et al. 2011

Modern Pathology

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Tumor necrosis factor alpha (TNFa) is an inflammatory cytokine that is present in the microenvironment of many tumors and is known to promote tumor progression. To examine how TNFa modulates the progression and metastasis of nasopharyngeal carcinoma, we used Affymetrix chips to identify TNFa-inducible genes that are dysregulated in this tumor. Elevated expression of TNFAIP2, which encodes TNFa-inducible protein 2 and not previously known to be associated with cancer, was found and confirmed by quantitative RT-PCR of TNFAIP2 expression in nasopharyngeal carcinoma and adjacent normal tissues. Immunohistochemical analysis showed that the TNFAIP2 protein was highly expressed in tumor cells. Analysis of 95 nasopharyngeal carcinoma biopsy specimens revealed that high TNFAIP2 expression was significantly correlated with highlevel intratumoral microvessel density (P ¼ 0.005) and low distant metastasis-free survival (P ¼ 0.001). A multivariate analysis further confirmed that TNFAIP2 was an independent prognostic factor for nasopharyngeal carcinoma (P ¼ 0.002). In vitro, TNFa treatment of nasopharyngeal carcinoma HK1 cells was found to induce TNFAIP2 expression, and siRNA-based knockdown of TNFAIP2 dramatically reduced the migration and invasion of nasopharyngeal carcinoma HK1 cells. These results collectively suggest for the first time that TNFAIP2 is a cell migration-promoting protein and its expression predicts distant metastasis. Our data suggest that TNFAIP2 may serve as an independent prognostic indicator for nasopharyngeal carcinoma.

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Section: Discussionmentioning

confidence: 99%

A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma

Chen

et al. 2011

Modern Pathology

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“…26 In addition to the inflammatory and dietary signals, GPR15 has been found to be upregulated in response to the dioxin-stimulation in several different cell lines. 27 This activation was rapid and it is the primary response to the dioxin because it was evident also in the presence of cycloheximide, the protein synthesis inhibitor. 27 This indicates that GPR15 can respond to more common environmental signals.…”

Section: 8mentioning

confidence: 99%

“…27 This activation was rapid and it is the primary response to the dioxin because it was evident also in the presence of cycloheximide, the protein synthesis inhibitor. 27 This indicates that GPR15 can respond to more common environmental signals.…”

Section: 8mentioning

confidence: 99%

Activation of GPR15 and its involvement in the biological effects of smoking

Kõks

2017

Exp Biol Med (Maywood)

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The review describes an orphan receptor GPR15 that has recently been found to be influenced by smoking. This makes GPR15 very sensitive and adequate biomarker for smoking and smoking studies. Also, activation of GPR15 by smoking could help to explain its effects on health. AbstractSmoking is one of the most significant modifiable environmental risk factors for many diseases. Smoking causes excessive mortality worldwide. Despite decades of long research, there has not been a clear understanding regarding the molecular mechanism that makes smoking harmful to health. Some recent studies have found that smoking influences most significantly the expression and methylation of GPR15. GPR15 is an orphan receptor that is involved in the regulation of the innate immunity and the T-cell trafficking in the intestinal epithelium. Further studies have confirmed that GPR15 is very strongly involved in smoking and smoking-induced molecular changes. Therefore, the altered expression and epigenetic regulation of GPR15 could have a significant role in the health impact of smoking.

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“…Collectively, these studies have uncovered a novel role of AhR in controlling colon homing of CD4 + T cells by positively regulating GPR15 expression in mice and humans. It is interesting to note that, retrospectively, there was already an indication of AhR regulation of GPR15 in 2007 when Gpr15 was identified as a novel dioxininducible gene (97).…”

Section: Regulation Of Gpr15 Expression By Aryl Hydrocarbon Receptormentioning

confidence: 99%

Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology

Okamoto

Shikano

2023

Front. Immunol.

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Chemokine receptors play a central role in the maintenance of immune homeostasis and development of inflammation by directing leukocyte migration to tissues. GPR15 is a G protein-coupled receptor (GPCR) that was initially known as a co-receptor for human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV), with structural similarity to other members of the chemoattractant receptor family. Since the discovery of its novel function as a colon-homing receptor of T cells in mice a decade ago, GPR15 has been rapidly gaining attention for its involvement in a variety of inflammatory and immune disorders. The recent identification of its natural ligand C10orf99, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues, has established that GPR15-C10orf99 is a novel signaling axis that controls intestinal homeostasis and inflammation through the migration of immune cells. In addition, it has been demonstrated that C10orf99-independent functions of GPR15 and GPR15-independent activities of C10orf99 also play significant roles in the pathophysiology. Therefore, GPR15 and its ligands are potential therapeutic targets. To provide a basis for the future development of GPR15- or GPR15 ligand-targeted therapeutics, we have summarized the latest advances in the role of GPR15 and its ligands in human diseases as well as the molecular mechanisms that regulate GPR15 expression and functions.

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Identification of novel dioxin-responsive genes by representational difference analysis

Cited by 11 publications

References 32 publications

A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma

A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma

Activation of GPR15 and its involvement in the biological effects of smoking

Emerging roles of a chemoattractant receptor GPR15 and ligands in pathophysiology

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