2001
DOI: 10.1128/jvi.75.3.1301-1311.2001
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Identification of Novel HLA-A2-Restricted Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Epitopes Predicted by the HLA-A2 Supertype Peptide-Binding Motif

Abstract: Virus-specific cytotoxic T-lymphocyte (CTL) responses

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Cited by 89 publications
(53 citation statements)
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“…Previous studies had shown that each of the HLA-A2 and HLA-A3 supertype epitopes was recognized in recall CTL assays using lymphocytes from HIV-infected subjects (53,73,74). Three of the seven HLA-B7 supertype-restricted peptides, Nef 94 (75), Env 250, and Env 259 (76), were also previously reported to be natural epitopes recognized in HIV-1-infected subjects.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies had shown that each of the HLA-A2 and HLA-A3 supertype epitopes was recognized in recall CTL assays using lymphocytes from HIV-infected subjects (53,73,74). Three of the seven HLA-B7 supertype-restricted peptides, Nef 94 (75), Env 250, and Env 259 (76), were also previously reported to be natural epitopes recognized in HIV-1-infected subjects.…”
Section: Discussionmentioning
confidence: 99%
“…Despite over 140 optimal CTL epitopes defined to date, no Vif and Vpu epitopes have been mapped (34) and only two HLA-A2-restricted epitopes within Vpr, predicted by the HLA-A2 peptidebinding motif, have been described previously (31). In addition to the three novel HLA-A3-and B7-restricted CTL epitopes described above in subject AC-06, we characterized the optimal CTL epitopes restricted by different HLA class I molecules for peptides recognized frequently in the studied individuals and determined the percentage of individuals with the corresponding HLA type recognizing the epitope (Table V).…”
Section: Identification Of Additional Ctl Epitopes Within the Accessomentioning
confidence: 99%
“…HLA typing was possible for 280 of these samples, of which 121 were HLA-A2 ϩ . OLP21 (PRTLNAWVKVVEEKAP, p24 [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] ) was recognized by 24 subjects, with most of this reactivity (14 of 24) likely directed against the HLA-B*1503-restricted VKV VEEKAF epitope frequently seen in HLA-B*1503-expressing subjects (21). Reactivity to the nonameric TV9 peptide was confirmed in one of two HLA-A2 ϩ HLA-B*1503 Ϫ samples tested that reacted to OLP21 (L8 47, 500 sfc/10 6 PBMCs; Fig.…”
Section: Tv9 Reactivity In Hiv-1-infected Subjectsmentioning
confidence: 99%
“…At the same time, these T cells are capable of producing sufficient autocrine factors to support prolonged periods of proliferation (24,25). These characteristics provide a plausible explanation for the paucity of circulating SL9-specific CD8 ϩ T cell reactivity during the proinflammatory acute phase of infection, as well as its paradoxical dominance during the CD4-diminished chronic phase of infection (18,26,27). The observation that SL9 and its mutations are highly conserved across clades (28), often emerging sequentially or even re-emerging within the same infection (18,29), is consistent with the idea that this epitope may oscillate around an optimal viral "solution" to a host population rich in HLA-A2 alleles (22).…”
mentioning
confidence: 99%