1995
DOI: 10.1016/0003-9969(95)00056-u
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Identification of osteopontin in human dental calculus matrix

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Cited by 20 publications
(9 citation statements)
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“…4) (35)(36)(37)(38)(39)(40)(41)(42). In vitro, osteopontin is a potent inhibitor of hydroxyapatite crystal growth (43), and we recently confirmed that addition of osteopontin also inhibits smooth muscle cell culture calcification.…”
Section: Osteopontin Is a Potent Inhibitor Of Vascular Cell Calcificamentioning
confidence: 75%
“…4) (35)(36)(37)(38)(39)(40)(41)(42). In vitro, osteopontin is a potent inhibitor of hydroxyapatite crystal growth (43), and we recently confirmed that addition of osteopontin also inhibits smooth muscle cell culture calcification.…”
Section: Osteopontin Is a Potent Inhibitor Of Vascular Cell Calcificamentioning
confidence: 75%
“…S was detected also in brain calcinosis along with Na, Mg and K [48]. Osteopontin, which has previously been detected in JDM deposits [8], was found in several other forms of pathological calcification: human pulp stones [49], urinary stones [50], human atherosclerotic lesions [51], and dental calculus [52]. Note that although dental calculus, pulp stones and urinary stones contain osteopontin (a known bone formation protein), they are very different from bone as well.…”
Section: Discussionmentioning
confidence: 99%
“…Kohri et al ( (1)) identified OPN as one of the major organic components of kidney stones by cloning and sequencing cDNA encoding urinary stone protein. OPN is a 44‐kDa phosphorylated glycoprotein originally identified in bone ( (4,5)) and has an RGD (arginine‐glycine‐aspartate) amino acid sequence functioning as an adhesion motif of the protein to integrins and CD44. ( (6,7)) OPN contains a series of aspartic acid domain(s) with high affinity to hydroxyapatite. ( (8)) The expression of OPN has been shown not only in physiological but also in pathological calcification, including atherosclerosis, breast cancer, dental calculus, pilomatricomas, and kidney stones. ( (9–12)) Changes in the expression level of OPN during experimental kidney stone formation have been extensively studied in rat models. After 4 wk of ethylene glycol, a precursor of oxalate, administration to rats, a dramatic increase in the expression of OPN protein and mRNA was found in renal epithelial cells, and the resulting kidney crystals also contained OPN. ( (1,3,13)) The results of hyperoxaluric rat models indicated that direct or indirect oxalate stimulus activates OPN expression in the epithelial cells of distal tubules.…”
Section: Introductionmentioning
confidence: 99%