Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies

Eidelman, Naomi; Boyde, A.; Bushby, A. J.; Howell, Peter; Sun, Jirun; Newbury, Dale E.; Miller, Frederick W.; Robey, Pamela Gehron; Rider, Lisa G.

doi:10.1186/ar2841

Cited by 39 publications

(33 citation statements)

References 51 publications

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“…Chemical composition (Ca/P) ratio has been previously used as a marker in EDS for the calculation of the mineral distribution in bone tissues [21][22][23] and is thus employed in our study. Twenty EDS spectra within an area of 100 Â 100 mm 2 were collected at the tested fracture surface of antler in order to determine the calcium content.…”

Section: Methodsmentioning

confidence: 99%

Nano-mechanical properties of individual mineralized collagen fibrils from bone tissue

Hang

Barber

2010

J. R. Soc. Interface.

118

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Mineralized collagen fibrils (MCFs) are distinct building blocks for bone material and perform an important mechanical function. A novel experimental technique using combined atomic force microscopy and scanning electron microscopy is used to manipulate and measure the mechanical properties of individual MCFs from antler, which is a representative bone tissue. The recorded stress -strain response of individual MCFs under tension shows an initial linear deformation region for all fibrils, followed by inhomogeneous deformation above a critical strain. This inhomogeneous deformation is indicative of fibrils exhibiting either yield or strain hardening and suggests possible mineral compositional changes within each fibril. A phenomenological model is used to describe the fibril nano-mechanical behaviour.

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Section: Methodsmentioning

confidence: 99%

Nano-mechanical properties of individual mineralized collagen fibrils from bone tissue

Hang

Barber

2010

J. R. Soc. Interface.

118

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“…The mineral is calcium hydroxyapatite or carbonate apatite, from x-ray diffraction, infrared spectroscopy and X-ray micro-computed tomography studies [60,61]. The properties of the mineral in the calcinosis lesions are closest to that of enamel, and the mineral clearly differs from bone.…”

Section: Pathogenesismentioning

confidence: 99%

“…The properties of the mineral in the calcinosis lesions are closest to that of enamel, and the mineral clearly differs from bone. The mineral appears to be deposited in fragments and becomes solid over time [61]. …”

Section: Pathogenesismentioning

confidence: 99%

The Presentation, Assessment, Pathogenesis, and Treatment of Calcinosis in Juvenile Dermatomyositis

et al. 2014

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Calcinosis is one of the hallmark sequelae of juvenile dermatomyositis (JDM), and despite recent progress in the therapy of JDM, dystrophic calcification still occurs in approximately one-third of patients. This review discusses our current, albeit limited, understanding of risk factors for the development of calcinosis in JDM, as well as approaches to assessment, and current views on its pathogenesis. Anecdotal approaches to treating calcinosis associated with JDM, including both anti-inflammatory therapies and agents aimed at inhibiting the deposition of calcium hydroxyapatite, are reviewed. An improved understanding of the pathogenesis of calcinosis, the establishment of standardized measurement tools to assess calcinosis, and randomized controlled trials employing more sensitive outcome measures are needed to develop efficacious therapies for this often disabling complication.

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“…Calcinosis occurs in 20–40% of patients 5;9;15 , with a lower prevalence in patients treated more aggressively who enter remission more rapidly 16 . Calcium and phosphate precipitate in the subcutaneous tissues and muscles as carbonate apatite, perhaps as a result of a loss of mineralization inhibitors 17 . Risk factors for calcinosis include delay to diagnosis, cardiac involvement, the need for additional immunosuppressive therapy, as well as a prolonged and/or severe illness course 15 .…”

Section: Clinicopathologic Classification Of Jiimmentioning

confidence: 99%

Developments in the Classification and Treatment of the Juvenile Idiopathic Inflammatory Myopathies

Rider¹,

Katz²,

Jones³

2013

Rheumatic Disease Clinics of North America

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The juvenile idiopathic inflammatory myopathies (JIIM) are rare, heterogeneous autoimmune diseases that share chronic muscle inflammation and weakness. JIIM broadly includes three major clinicopathologic groups: juvenile dermatomyositis, juvenile polymyositis, and overlap myositis. A growing spectrum of clinicopathologic groups and serologic phenotypes defined by the presence of myositis-specific or myositis-associated autoantibodies are now recognized, each with differing demographics, clinical manifestations, laboratory findings, and prognoses. With the first multi-center collaborative studies and controlled trials using standardized preliminarily validated outcome measures, the therapy of juvenile myositis has advanced. Although daily oral corticosteroids remain the backbone of treatment, disease-modifying anti-rheumatic drugs (DMARDs) are almost always used as adjunctive therapy. Methotrexate is the conventional DMARD for the initial therapy, either alone or combined with intravenous pulse methylprednisolone, and/or intravenous immunoglobulin for patients with moderate to severe disease. Cyclosporine may be added to these or serve as an alternative to methotrexate. Other drugs and biologic therapies, including mycophenolate mofetil, tacrolimus, cyclophosphamide, rituximab, and infliximab, might benefit selected patients with recalcitrant disease, unacceptable steroid toxicity, or patients with risk factors for poor prognosis. The treatment of cutaneous disease, calcinosis, and the role for rehabilitation are also discussed.

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Microstructure and mineral composition of dystrophic calcification associated with the idiopathic inflammatory myopathies

Cited by 39 publications

References 51 publications

Nano-mechanical properties of individual mineralized collagen fibrils from bone tissue

Nano-mechanical properties of individual mineralized collagen fibrils from bone tissue

The Presentation, Assessment, Pathogenesis, and Treatment of Calcinosis in Juvenile Dermatomyositis

Developments in the Classification and Treatment of the Juvenile Idiopathic Inflammatory Myopathies

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