Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

Li, Heng; Zhang, Xianglei; Xiang, Caigui; Feng, Chen‐Guo; Chen, Fan; Liu, Moting; Lu, Huimin; Zhang, Yu; Qi, Qing; Xu, Yechun; Tang, Wei

doi:10.1016/j.jare.2021.02.006

Cited by 15 publications

(11 citation statements)

References 40 publications

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“…Arctigenin inhibited pro-inflammatory cytokines and chemokines in LPS-induced RAW264.7 murine macrophage-like cells in vitro as well as in vivo, remarkably reduced the congestion and necroinflammation of liver, decreased the infiltration of CD4 T and NKT cells and macrophages into the liver and suppressed T lymphocyte proliferation in a murine model of concanavalin A-induced acute hepatitis [ 188 ]. In LPS-primed human PBMCs and murine RAW264.7 cells in vitro and in imiquimod-induced murine psoriasis model in vivo, arctigenin inhibited activity of PDE4 and activated the cAMP-dependent protein kinase A/cAMP-response element binding protein (PKA/CREB) signaling, ameliorated psoriatic manifestations by decreasing the adhesion and chemotaxis of inflammatory cells, rectifying the immune dysfunction and hyperactivation of keratinocytes in the inflamed skin microenvironments, reducing the production of inflammatory cytokines and promoting the secretion of IL-10 [ 78 , 190 ].…”

Section: Lignans With Antioxidant and Anti-inflammatory Actionmentioning

confidence: 99%

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Osmakov

Kalinovskii

Belozerova

et al. 2022

IJMS

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Plant lignans exhibit a wide range of biological activities, which makes them the research objects of potential use as therapeutic agents. They provide diverse naturally-occurring pharmacophores and are available for production by chemical synthesis. A large amount of accumulated data indicates that lignans of different structural groups are apt to demonstrate both anti-inflammatory and antioxidant effects, in many cases, simultaneously. In this review, we summarize the comprehensive knowledge about lignan use as a bioactive agent in disorders associated with oxidative stress and inflammation, pharmacological effects in vitro and in vivo, molecular mechanisms underlying these effects, and chemical synthesis approaches. This article provides an up-to-date overview of the current data in this area, available in PubMed, Scopus, and Web of Science databases, screened from 2000 to 2022.

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Section: Lignans With Antioxidant and Anti-inflammatory Actionmentioning

confidence: 99%

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Osmakov

Kalinovskii

Belozerova

et al. 2022

IJMS

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“…Inflammatory response is a very complex biological process, which has an important role in many diseases ( Costa et al., 2021 ; Li et al., 2021 ; Lu et al., 2021 ; Wang J. et al., 2021 ). Previous studies showed that inflammatory response played a critical role in the onset of depression, and the disturbance of inflammation levels could increase the incidence of depression ( Leonard, 2018 ; Colasanto et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Bai

et al. 2022

Front. Cell. Infect. Microbiol.

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ObjectiveAlthough many works have been done, the objectively measured diagnostic biomarkers are not available. Thus, we conducted this study to identify potential biomarkers for objectively diagnosing depression and explore the role of gut microbiota in the onset of depression.MethodsMajor depressive disorder (MDD) patients (n=56) and demographic data-matched healthy controls (HCs) (n=56) were included in this study. The gut microbiota in fecal samples and inflammation-related factors in serum were measured. Both univariate and multivariate statistical analyses were performed to identify the differential gut microbiota and inflammation-related factors.ResultsFinally, 46 differential operational taxonomic units (OTUs) (60.9% OTUs belonging to Firmicutes) and ten differential inflammation-related factors were identified. Correlation analysis showed that there were significant correlations between 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and seven differential inflammation-related factors. Meanwhile, 14 differential OTUs (9 OTUs belonging to Firmicutes and 5 OTUs belonging to family Lachnospiraceae under Firmicutes) and five differential inflammation-related factors (adiponectin, apolipoprotein A1, alpha 1-antitrypsin, neutrophilicgranulocyte count/white blood cell count and basophil count) were significantly correlated to depression severity. A panel consisting of these five differential inflammation-related factors could effectively diagnose MDD patients from HCs.ConclusionsOur results suggested that Firmicutes, especially family Lachnospiraceae, might play a role in the onset of depression via affecting the inflammation levels of host, and these five differential inflammation-related factors could be potential biomarkers for objectively diagnosing MDD.

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“…Oral administration of arctigenin has anti-inflammatory effects in many tissues such as brain, kidney, and skin. 12,29,30) Orally administered arctigenin is mainly absorbed in the small intestine. It is converted into glucuronate conjugate by UDPglucuronosyltransferase in the liver and intestine followed by its excretion.…”

Section: Discussionmentioning

confidence: 99%

Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model

Hidaka

Nakamura

Nishinaka

et al. 2023

Biological & Pharmaceutical Bulletin

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Macular edema causes vision loss in patients with retinal vein occlusion (RVO) and diabetic macular edema (DME). The intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents is used for treatment; however, this therapy is invasive, and recurrence occurs in some cases. The establishment of a non-invasive treatment would help to solve these problems. Here, we focused on arctigenin, a lignan polyphenol found in burdock sprout, and has effects on inflammatory and microcirculatory when taken orally. We hypothesized that oral intake of arctigenin could be effective against retinal edema in RVO and DME. In this study, the degree of retinal edema by measuring the total retinal thickness using optical coherence tomography (OCT) and the thickness of the inner nuclear layer (INL) by hematoxylin-eosin (H&E) staining were investigated. Oral administration of arctigenin ameliorated retinal edema in an RVO murine model by inhibiting the decrease in occludin and vascular endothelial (VE)-cadherin. Moreover, in retinas with edema, arctigenin suppressed the induction of VEGF, tumor necrosis factor α (TNFα), and matrix metallopeptidase 9 (MMP9). Next, the effects of arctigenin on barrier function were assessed in human retinal microvascular endothelial cells (HRMECs) by measuring the trans-endothelial electrical resistance (TEER) and conducting fluorescein isothiocyanate (FITC)-dextran permeability assays. Arctigenin showed a protective effect against VEGF-induced barrier dysfunction. In addition, arctigenin inhibited the TNFα-mediated activation of the nuclear factor-kappaB (NF-κB)/p38 mitogen-activated protein kinase (MAPK) pathway. These results suggested that oral administration of arctigenin has beneficial effects on retinal edema by inhibiting vascular hyperpermeability in endothelial cells.

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Identification of phosphodiesterase-4 as the therapeutic target of arctigenin in alleviating psoriatic skin inflammation

Cited by 15 publications

References 40 publications

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Lignans as Pharmacological Agents in Disorders Related to Oxidative Stress and Inflammation: Chemical Synthesis Approaches and Biological Activities

Gut Microbiota-Related Inflammation Factors as a Potential Biomarker for Diagnosing Major Depressive Disorder

Arctigenin Prevents Retinal Edema in a Murine Retinal Vein Occlusion Model

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