Identification of plasma lncRNA-ATB levels in hepatitis B virus-related cirrhosis and non-cirrhotic chronic hepatitis B patients

Shoraka, Shahrzad; Mohebbi, Seyed Reza; Hosseini, Seyed Masoud; Aghdaei, Hamid Asadzadeh; Zali, Mohammad Reza

doi:10.1016/j.virusres.2021.198503

Cited by 8 publications

(2 citation statements)

References 47 publications

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“…In viral infections, the study of miRNAs in body fluids identified potential biomarkers for Ebola virus [ 172 ], HIV-1 [ 173 ], influenza A virus (IAV) [ 174 ], and rhinovirus [ 175 ] infections, which was further reviewed by [ 176 ]. Furthermore, the lncRNAs in biofluids have been reported as diagnostic markers for chronic hepatitis B virus (HBV) [ 177 ] and HBV-related cirrhosis [ 178 ], and as a prognostic marker for visual acuity in patients with acute retinal necrosis caused by herpes simplex virus type-1 (HSV-1) [ 179 ]. In addition, the circulating snoRNAs have been reported as potential prognostic markers for COVID-19 severity [ 180 ].…”

Section: Discussionmentioning

confidence: 99%

The Host Non-Coding RNA Response to Alphavirus Infection

Behnia

Bradfute

2023

Viruses

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Alphaviruses are important human and animal pathogens that can cause a range of debilitating symptoms and are found worldwide. These include arthralgic diseases caused by Old-World viruses and encephalitis induced by infection with New-World alphaviruses. Non-coding RNAs do not encode for proteins, but can modulate cellular response pathways in a myriad of ways. There are several classes of non-coding RNAs, some more well-studied than others. Much research has focused on the mRNA response to infection against alphaviruses, but analysis of non-coding RNA responses has been more limited until recently. This review covers what is known regarding host cell non-coding RNA responses in alphavirus infections and highlights gaps in the knowledge that future research should address.

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Section: Discussionmentioning

confidence: 99%

The Host Non-Coding RNA Response to Alphavirus Infection

Behnia

Bradfute

2023

Viruses

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“…LncRNA-ATB, which is activated by TGF-β, is a key regulator of the TGF-β signaling pathway. The plasma levels of lncRNA-ATB in HBV-related cirrhosis patients were significantly higher than those in healthy controls[ 27 ].…”

Section: Lncrnas In Hbv-related Chronic Diseasesmentioning

confidence: 99%

Long noncoding RNAs in hepatitis B virus replication and oncogenesis

Li¹,

Yang²,

Lo³

2022

WJG

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Several diverse long noncoding RNAs (lncRNAs) have been identified to be involved in hepatitis B virus (HBV) replication and oncogenesis, especially those dysregulated in HBV-related hepatocellular carcinoma (HCC). Most of these dysregulated lncRNAs are modulated by the HBV X protein. The regulatory mechanisms of some lncRNAs in HBV replication and oncogenesis have been characterized. Genetic polymorphisms of several lncRNAs affecting HBV replication or oncogenesis have also been studied. The prognosis of HCC remains poor. It is important to identify novel tumor markers for early diagnosis and find more therapeutic targets for effective treatments of HCC. Some dysregulated lncRNAs in HBV-related HCC may become biomarkers for early diagnosis and/or the therapeutic targets of HCC. This mini-review summarizes these findings briefly, focusing on recent developments.

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