“…It forms a strong hydrogen bond of length 1.91 Å with Asp187 and also forms hydrophobic interactions with Tyr54, Met49, Met165, Phe140, Leu141, Cys145 and Leu27 and polar interactions with His41, Gln189, His 164, His163, His172, Asn142, Ser144 and Thr26. It has been reported that binding to the Arg188/Gln189 site reduces the catalytic activity of the protein [ 61 ].…”