Identification of predominant SNPs as a novel method for genotyping bovine<i>Staphylococcus aureus</i>isolates

Hall, Jeffrey W.; Ji, Yinduo

doi:10.4161/viru.3.1.18724

Cited by 2 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also, isolates causing clinical mastitis show higher hemolytic activity and prevalence of hemolysin genes when compared to isolates recovered from subclinical mastitis [163,188], which may result in greater damage of the bovine mammary secretory epithelial cells. In addition, the presence of single nucleotide polymorphisms within the promoter region of hla is likely to be associated with a high α-hemolysin expression by S. aureus isolates associated with severe bovine mastitis, a finding that may be used as a marker to discriminate strain virulence [189].…”

Section: Toxins As Important Virulence Factors In Mastitismentioning

confidence: 99%

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives

et al. 2022

View full text Add to dashboard Cite

Staphylococcus aureus is a leading cause of bovine mastitis worldwide. Despite some improved understanding of disease pathogenesis, progress towards new methods for the control of intramammary infections (IMI) has been limited, particularly in the field of vaccination. Although herd management programs have helped to reduce the number of clinical cases, S. aureus mastitis remains a major disease burden. This review summarizes the past 16 years of research on bovine S. aureus population genetics, and molecular pathogenesis that have been conducted worldwide. We describe the diversity of S. aureus associated with bovine mastitis and the geographical distribution of S. aureus clones in different continents. We also describe studies investigating the evolution of bovine S. aureus and the importance of host-adaptation in its emergence as a mastitis pathogen. The available information on the prevalence of virulence determinants and their functional relevance during the pathogenesis of bovine mastitis are also discussed. Although traits such as biofilm formation and innate immune evasion are critical for the persistence of bacteria, the current understanding of the key host-pathogen interactions that determine the outcome of S. aureus IMI is very limited. We suggest that greater investment in research into the genetic and molecular basis of bovine S. aureus pathogenesis is essential for the identification of novel therapeutic and vaccine targets.

show abstract

Section: Toxins As Important Virulence Factors In Mastitismentioning

confidence: 99%

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives

et al. 2022

View full text Add to dashboard Cite

show abstract

Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

Jiang,

Cameron,

Nethercott

et al. 2023

Clin Microbiol Rev

View full text Add to dashboard Cite

SUMMARY Methicillin-resistant Staphylococcus aureus (MRSA) is a leading cause of severe and often fatal infections. MRSA epidemics have occurred in waves, whereby a previously successful lineage has been replaced by a more fit and better adapted lineage. Selection pressures in both hospital and community settings are not uniform across the globe, which has resulted in geographically distinct epidemiology. This review focuses on the mechanisms that trigger the establishment and maintenance of current, dominant MRSA lineages across the globe. While the important role of antibiotic resistance will be mentioned throughout, factors which influence the capacity of S. aureus to colonize and cause disease within a host will be the primary focus of this review. We show that while MRSA possesses a diverse arsenal of toxins including alpha-toxin, the success of a lineage involves more than just producing toxins that damage the host. Success is often attributed to the acquisition or loss of genetic elements involved in colonization and niche adaptation such as the arginine catabolic mobile element, as well as the activity of regulatory systems, and shift metabolism accordingly (e.g., the accessory genome regulator, agr ). Understanding exactly how specific MRSA clones cause prolonged epidemics may reveal targets for therapies, whereby both core (e.g., the alpha toxin) and acquired virulence factors (e.g., the Panton-Valentine leukocidin) may be nullified using anti-virulence strategies.

show abstract

Identification of predominant SNPs as a novel method for genotyping bovineStaphylococcus aureusisolates

Cited by 2 publications

References 17 publications

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives

Diversity and pathogenesis of Staphylococcus aureus from bovine mastitis: current understanding and future perspectives

Virulence attributes of successful methicillin-resistant Staphylococcus aureus lineages

Contact Info

Product

Resources

About