Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis

Saad, Mohamed N.; Mabrouk, Mai S.; Eldeib, Ayman M.; Shaker, Olfat G.

doi:10.1016/j.jare.2015.01.008

Cited by 40 publications

(25 citation statements)

References 98 publications

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“…SNPs always show more biological significance when SNP clusters are tightly organized into haplotype blocks in the examined genomic region [28]. Association analysis with SNPLDBs increases the power of association [6,30]. In fact, compared with individual SNPs, constructed SNPLDB has a higher meaning, enhancing the accuracy and robustness of association analysis [8,11].…”

Section: Advantage Of Snpldbs For Association Analysismentioning

confidence: 99%

Association analysis between constructed SNPLDBs and GCA effects of 9 quality-related traits in parents of hybrid rice (Oryza sativa L.)

et al. 2020

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Background: The general combining ability (GCA) of parents in hybrid rice affects not only heterotic level of grain yield and other important agronomic traits, but also performance of grain quality traits of F 2 bulk population which is the commodity consumed by humans. In order to make GCA improvement for quality traits in parents of hybrid rice by molecular marker assisted selection feasible, genome-wide GCA loci for quality traits in parents were detected through association analysis between the effects of GCA and constructed single nucleotide polymorphism linkage disequilibrium blocks (SNPLDBs), by using unhusked rice grains harvested from F 1 plants of 48 crosses of Indica rice and 78 crosses of Japonica rice. GCA-SNPLDBs association analysis. Results: Among the 8 CMS and 6 restorer lines of indica rice subspecies, CMS lines Zhenpin A, Zhenshan97 A, and 257A, and restorers Kanghui98, Minghui63 and Yanhui559 were recognized as good general combiners based on their GCA effect values for the 9 quality traits (brown rice rate, milled rice rate, head rice rate, percentage of chalky grains, chalky area size, chalkiness degree, gelatinization temperature, gel consistency and amylose content). Among the 13 CMS and 6 restorer lines of japonica rice subspecies, CMS 863A, 6427A and Xu 2A, and restorers C418, Ninghui8hao and Yunhui4hao showed elite GCA effect values for the 9 traits. GCA-SNPLDB association analysis revealed 39 significant SNPLDB loci associated with the GCA of the 9 quality-related traits, and the numbers of SNPLDB loci located on chromosome 1,

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Section: Advantage Of Snpldbs For Association Analysismentioning

confidence: 99%

Association analysis between constructed SNPLDBs and GCA effects of 9 quality-related traits in parents of hybrid rice (Oryza sativa L.)

et al. 2020

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“…RA is a chronic disease associated with inflammation of the joints and the surrounding tissue, and linked with functional disability, and RA is associated in some cases with sSS as an extra‐articular manifestation. The cellular and molecular mechanisms involved in the etiology of RA have been recently a major thrust area in the worldwide research; however, it has not been established yet . Early diagnosis and assessment of its risk factors are of paramount importance towards effective management.…”

Section: Discussionmentioning

confidence: 94%

“…Sjögren's syndrome (SS) is a chronic autoimmune disease characterized by lymphocytic infiltration of the salivary and lacrimal glands , and exists as primary (pSS) and secondary (sSS), depending on whether it occurs alone, or with other connective diseases, including systemic lupus erythematosus and RA . RA is a complex disease, and both genetic and environmental factors contribute to its pathogenesis . Twin studies demonstrated that 60% of RA risk is due to inherited predisposition .…”

Section: Introductionmentioning

confidence: 99%

HLA DRB1/DQB1 alleles and DRB1‐DQB1 haplotypes and the risk of rheumatoid arthritis in Tunisians: a population‐based case–control study

Lagha

Messadi

Boussaidi

et al. 2016

HLA

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Rheumatoid arthritis (RA) is an inflammatory disease, which affects synovial joints, and is influenced by environmental and genetic factors, in particular the human leucocyte antigen (HLA) system. In our study, we investigated the association of HLA class II DRB1 and DQB1 alleles and DRB1-DQB1 haplotypes with RA susceptibility in Tunisian subjects. Therefore, HLA class II low-resolution genotyping was done in 110 RA patients and 116 controls, with a HLA-DRB1*04 high-resolution typing. Our results showed a strong association between HLA-DRB1*04/DRB1*04:05 alleles and RA presence, which persisted after correcting for multiple comparisons (Pc < 10-3, Pc = 0.020, respectively), in contrast to the protective effect of HLA-DRB1*04:03 allele (Pc = 15.2 × 10-4). However, increased frequency of DQB1*05 (Pc = 0.020) and decreased frequency of DRB1*04:03 subtype (Pc = 0.032) were seen in RF+ patients than controls. Moreover, when RA patients were compared to controls, DRB1*04-DQB1*03 haplotype was associated with RA susceptibility in Tunisians (Pc = 16.8 × 10-5), independently of RF status. Conversely, DRB1*01 allele and DRB1*01-DQB1*05 haplotype was highly present in RF+ vs RF- groups (Pc < 10-3, Pc = 5.6 × 10-3, respectively) and seems to be linked to seropositivity. Investigation of HLA class II alleles and haplotypes association with RA susceptibility with secondary Sjögren's syndrome (sSS) showed a predisposing effect of DRB1*04 (Pc < 10-3) and DRB1*04-DQB1*03 haplotype when RA with sSS/without sSS groups were compared to healthy controls. Our results confirms the association of HLA-DRB1*04, specifically HLA-DRB1*04:05 subtype, and DRB1*04-DQB1*03 haplotype with RA susceptibility in Tunisians, independently of seropositivity or the sSS presence.

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“…1,2 A nivel mundial la población afectada por AR es de 1%. 3 Sin embargo, en México el 1.6% presenta esta patología. 4 Por otra parte, la periodontitis es una enfermedad crónica, inflamatoria e infecciosa de los tejidos de sostén de los órganos dentales.…”

Section: Introductionunclassified

Relación de la periodontitis y artritis reumatoide a través del eje IL-23/IL-17A

Rodríguez-Montaño¹,

Aguilar-Carrillo²,

Bernard-Medina³

et al. 2019

Revista Mexicana De Periodontología

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Revisión bibliogRáfica RESUMEN La artritis reumatoide (AR) y la periodontitis (P) son enfermedades inflamatorias crónicas. De manera reciente, se ha descrito que 90% de los pacientes con AR presentan P. Ambas patologías se caracterizan por la destrucción de la articulación y el hueso alveolar, respectivamente. Se sabe que 1% de la población mundial presenta artilugios y en México es el 1.6%. Sobre la periodontitis, su prevalencia es de 15 a 20% de la población mundial y en México es de 60%. La etiología de ambas enfermedades es similar, ya que son multifactoriales y comparten varios factores de riesgo que pueden desencadenarlas, como lo son factores genéticos, biológicos o ambientales, dentro de los cuales uno de los que mantiene más cercana la relación de estas enfermedades es el factor biológico, donde una disbiosis a nivel bucal o intestinal puede comenzar con inflamación local y a su vez sistemática. Las citocinas proinflamatorias IL-23 e IL-17 y sus receptores juegan un papel muy importante en la inmunopatología de estas enfermedades. IL-23 activa y expande los clones Th17 a través de IL-23R y promueve la producción de IL-17 y RANKL; sin embargo, la IL-23R soluble puede bloquear el receptor de IL-23 al inhibir su señalización. IL-17 a través de IL-17RA puede activar fibroblastos y macrófagos que expresan RANKL que activa los precursores de osteoclastos e inicia la erosión ósea en las articulaciones y el hueso alveolar. Al igual que el receptor soluble de IL-23R, el ser soluble de IL-17RA puede bloquear a IL-17A e inhibir su señalización.

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Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis

Abstract: Graphical abstract

Cited by 40 publications

References 98 publications

Association analysis between constructed SNPLDBs and GCA effects of 9 quality-related traits in parents of hybrid rice (Oryza sativa L.)

Association analysis between constructed SNPLDBs and GCA effects of 9 quality-related traits in parents of hybrid rice (Oryza sativa L.)

HLA DRB1/DQB1 alleles and DRB1‐DQB1 haplotypes and the risk of rheumatoid arthritis in Tunisians: a population‐based case–control study

Relación de la periodontitis y artritis reumatoide a través del eje IL-23/IL-17A

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