Identification of sacrococcygeal and pelvic abscesses infected with invasive <i>Mycoplasma hominis</i> by MALDI‐TOF MS

Fang, Su; Zhang, Junwu; Zhu, Yongze; Lv, H.-J.; Ge, Yumei

doi:10.1002/jcla.24329

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…In this case, under the guidance of NGS, we deliberately extended the incubation time of blood culture medium transferred to blood agar plate. Moreover, MALDI-TOF MS shows an excellent performance for the identification of Mycoplasma hominis [19,20].…”

Section: Discussionmentioning

confidence: 99%

Application of Next-Generation Sequencing on Diagnosis of Bloodstream Infection Caused by Mycoplasma hominis in a Patient With ANCA-Associated Vasculitis

Chen

Huang

et al. 2022

Preprint

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Background: Mycoplasma hominis is one of the main opportunistic pathogenic Mycoplasma in human which has a major impact on patients with bloodstream infections. Because it is difficult to detect or isolate, the rapid and accurate diagnosis is essential and still challenging for patients with bloodstream infection. Case presentation: In this case, we reported the application of next -generation sequencing on diagnosis of bloodstream infection caused by Mycoplasma hominis in a patient with ANCA-associated vasculitis. After 9 days of combined treatment with levofloxacin, polymyxin B, and meropenem, the patient’s infected situation was gradually controlled and he was discharged without further complications. During the three-month outpatient follow-up, no recurrence of symptoms or signs was reported. Conclusions: This successful application of the next generation sequencing assisted the rapid diagnosis of Mycoplasma hominis bloodstream infection, provided a new perspective in the clinical approach and highlighted the potential of this technique in rapid etiological diagnosis.

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Section: Discussionmentioning

confidence: 99%

Application of Next-Generation Sequencing on Diagnosis of Bloodstream Infection Caused by Mycoplasma hominis in a Patient With ANCA-Associated Vasculitis

Chen

Huang

et al. 2022

Preprint

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“…First, a remarkable feature of bacteria is that their genetics can be simply modified to produce and release specific compounds, which can combine with the production of specific toxins to stimulate an effective immune response, which leads to tumor regression ( Forbes, 2010 ; Danino et al, 2015 ; Kucerova and Cervinkova, 2016 ; Xu et al, 2018 ). Second, different bacterial species can colonize various body sites of mammalian hosts, such as the skin, the urogenital system, and the gut, as well as disease sites (e.g., abscesses and tumor tissues) ( Talib and Mahasneh, 2012 ; Fan et al, 2018 ; Su et al, 2022 ). In particular, the inherent tropism of bacteria for different types of tumors and their ability to overcome the vascular barrier means that they have potential for use in tumor-targeting delivery ( Wu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances in bacteria-mediated cancer therapy

Liang

Wang

Shao

et al. 2022

Front. Bioeng. Biotechnol.

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Cancer is among the leading cause of deaths worldwide. Although conventional therapies have been applied in the fight against the cancer, the poor oxygen, low extracellular pH, and high interstitial fluid pressure of the tumor microenvironment mean that these treatments fail to completely eradicate cancer cells. Recently, bacteria have increasingly been considered to be a promising platform for cancer therapy thanks to their many unique properties, such as specific tumor-targeting ability, high motility, immunogenicity, and their use as gene or drug carriers. Several types of bacteria have already been used for solid and metastatic tumor therapies, with promising results. With the development of synthetic biology, engineered bacteria have been endowed with the controllable expression of therapeutic proteins. Meanwhile, nanomaterials have been widely used to modify bacteria for targeted drug delivery, photothermal therapy, magnetothermal therapy, and photodynamic therapy, while promoting the antitumor efficiency of synergistic cancer therapies. This review will provide a brief introduction to the foundation of bacterial biotherapy. We begin by summarizing the recent advances in the use of many different types of bacteria in multiple targeted tumor therapies. We will then discuss the future prospects of bacteria-mediated cancer therapies.

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Identification of sacrococcygeal and pelvic abscesses infected with invasive Mycoplasma hominis by MALDI‐TOF MS

Fang

Zhang

Zhu

et al. 2022

Clinical Laboratory Analysis

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Identification of sacrococcygeal and pelvic abscesses infected with invasive Mycoplasma hominis by MALDI‐TOF MS

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 6 publications

References 24 publications

Application of Next-Generation Sequencing on Diagnosis of Bloodstream Infection Caused by Mycoplasma hominis in a Patient With ANCA-Associated Vasculitis

Application of Next-Generation Sequencing on Diagnosis of Bloodstream Infection Caused by Mycoplasma hominis in a Patient With ANCA-Associated Vasculitis

Recent advances in bacteria-mediated cancer therapy

Identification of sacrococcygeal and pelvic abscesses infected with invasive Mycoplasma hominis by MALDI‐TOF MS

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