Identification of <scp>HLA‐DPA1</scp>*01:03:01:57 and <scp>HLA‐DPA1</scp>*02:01:01:29 from a case–control study of atopic dermatitis

In this review, we provide an overview of food allergy genetics and epigenetics aimed at clinicians and researchers. This includes a brief review of the current understanding of genetic and epigenetic mechanisms, inheritance of food allergy, as well as a discussion of advantages and limitations of the different types of studies in genetic research. We specifically focus on the results of genome‐wide association studies in food allergy, which have identified 16 genetic variants that reach genome‐wide significance, many of which overlap with other allergic diseases, including asthma, atopic dermatitis, and allergic rhinitis. Identified genes for food allergy are mainly involved in epithelial barrier function (e.g., FLG, SERPINB7) and immune function (e.g., HLA, IL4). Epigenome‐wide significant findings at 32 loci are also summarized as well as 14 additional loci with significance at a false discovery of < 1 × 10−4. Integration of epigenetic and genetic data is discussed in the context of disease mechanisms, many of which are shared with other allergic diseases. The potential utility of genetic and epigenetic discoveries is deliberated. In the future, genetic and epigenetic markers may offer ways to predict the presence or absence of clinical IgE‐mediated food allergy among sensitized individuals, likelihood of development of natural tolerance, and response to immunotherapy.

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Nomenclature for factors of the HLA system, update January, February and March 2023

Marsh

2023

Int J Immunogenetics

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Identification of *HLA‐DPA1***01:03:01:57* and *HLA‐DPA1***02:01:01:29* from a case–control study of atopic dermatitis

Abstract: DPA101:03:01:57 and DPA102:01:01:29 differ by a single nucleotide from their closest references, DPA101:03:01:02 and DPA102:01:01:06.

Cited by 4 publications

References 4 publications

Nomenclature for factors of the HLA system, update January, February and March 2023

Nomenclature for factors of the HLA system, update January, February and March 2023

Food Allergy Genetics and Epigenetics: A Review of Genome‐Wide Association Studies

Nomenclature for factors of the HLA system, update January, February and March 2023

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Identification of HLA‐DPA1*01:03:01:57 and HLA‐DPA1*02:01:01:29 from a case–control study of atopic dermatitis

Abstract: DPA1*01:03:01:57 and DPA1*02:01:01:29 differ by a single nucleotide from their closest references, DPA1*01:03:01:02 and DPA1*02:01:01:06.

Cited by 4 publications

References 4 publications

Nomenclature for factors of the HLA system, update January, February and March 2023

Nomenclature for factors of the HLA system, update January, February and March 2023

Food Allergy Genetics and Epigenetics: A Review of Genome‐Wide Association Studies

Nomenclature for factors of the HLA system, update January, February and March 2023

Contact Info

Product

Resources

About

Identification of *HLA‐DPA1***01:03:01:57* and *HLA‐DPA1***02:01:01:29* from a case–control study of atopic dermatitis

Abstract: DPA101:03:01:57 and DPA102:01:01:29 differ by a single nucleotide from their closest references, DPA101:03:01:02 and DPA102:01:01:06.