Identification of selectively expressed genes and antigens in CTCL

Hartmann, Tanja B.; Mattern, Eva; Wiedemann, Nicole; Doorn, Remco van; Willemze, Rein; Niikura, Takako; Hildenbrand, Ralf; Schadendorf, Dirk; Eichmüller, Stefan B.

doi:10.1111/j.1600-0625.2007.00637.x

Cited by 27 publications

(28 citation statements)

References 58 publications

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“…12 Tat-interacting protein of 110 kDa (TIP110), which was initially cloned from a human KG-1 myeloid cell line cDNA library, 13 is implicated in RNA metabolism and tumor-antigen presentation. [14][15][16][17] We demonstrated previously that TIP110 regulates the transcription of HIV-1 and cellular genes. 18,19 It is considered a mammalian homolog of the yeast Prp24 protein, and functions as a general pre-mRNA splicing factor.…”

Section: Introductionmentioning

confidence: 99%

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu¹,

Timani²,

Mantel³

et al. 2011

Blood

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Intracellular factors are involved in and essential for hematopoiesis. HIV-1 Tat-interacting protein of 110 kDa (TIP110; p110 nrb / SART3/p110) is an RNA-binding nuclear protein implicated in the regulation of HIV-1 gene and host gene transcription, premRNA splicing, and cancer immunology. In the present study, we demonstrate a role for TIP110 in the regulation of hematopoiesis. TIP110 was expressed in human CD34 ؉ cells and decreased with differentiation of CD34 ؉ cells. TIP110 mRNA was also expressed in phenotyped mouse marrow hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). Using TIP110 transgenic (TIP110 TG ) and haploinsufficient (TIP110 ؉/؊ ) mice, we found that increased TIP110 expression enhanced HPC numbers, survival, and cell cycling, whereas decreased TIP110 expression had the opposite effects. Moreover, TIP110 ؉/؊ bone marrow HPCs responded more effectively, and TIP110 TG HPCs less effectively, than those of wild-type control mice to recovery from the cell-cycle-active drug 5-fluorouracil (5-FU). Unexplained sex differences were noted in HSC competitive repopulating ability, but not HPC numbers, in TIP110 TG mice. Intracellularly, TIP110 regulated CMYC and GATA2 expression at the transcriptional level, and TIP110 and CMYC reciprocally regulated the expression of each other. These results demonstrate a role for TIP110 in the regulation of hematopoiesis, effects that are likely linked to TIP110 regulation of CMYC. IntroductionHematopoiesis is regulated at the level of hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs) via intracellular and extracellular molecules. [1][2][3] Homeostasis is crucial for normal hematopoiesis. 2 Cell cycling of HSCs/HPCs is regulated by growth factors/cytokines, as well as by transcription factors such as C-MYB, CMYC, GATA2, HOX family proteins, and BMI-1. C-MYB promotes HSC growth through induced CMYC. [4][5][6] CMYC induces the expression of positive regulators involved in G1/S cell-cycle transition, and also represses negative regulators of the cell cycle, events required for the proliferation of hematopoietic progenitors. 7 CMYC is involved in cell proliferation and growth, angiogenesis, apoptosis, differentiation, and regulation of chromatin structure, [8][9][10][11] and plays a role in controlling self-renewal and differentiation of HSCs. 12 Tat-interacting protein of 110 kDa (TIP110), which was initially cloned from a human KG-1 myeloid cell line cDNA library, 13 is implicated in RNA metabolism and tumor-antigen presentation. [14][15][16][17] We demonstrated previously that TIP110 regulates the transcription of HIV-1 and cellular genes. 18,19 It is considered a mammalian homolog of the yeast Prp24 protein, and functions as a general pre-mRNA splicing factor. 20 Using molecular, cellular, and genetic strategies, including TIP110 transgenic (TIP110 TG ) and conditional knockout (TIP110 ϩ/Ϫ ) mice, ectopic expression, and shRNA knockdown, we found that TIP110 regulates HPC/HSC function, effects likely involving cell-cycl...

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Section: Introductionmentioning

confidence: 99%

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

Liu¹,

Timani²,

Mantel³

et al. 2011

Blood

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“…Specific antibodies against NUDC could be useful in inhibiting the growth of these carcinogenic cells [49]. hNUDC was also identified in cutaneous T-cell lymphoma by serological identification of antigens which have triggered the immunological response in tumor-bearing patients [50]. hNUDC has also been identified in a proteomic background study of esophageal cancer comparing tumor cells and the matched neighboring normal epithelial cells from surgical specimens.…”

Section: Functions Of Mammalian Nudcmentioning

confidence: 99%

The mammalian NudC-like genes: a family with functions other than regulating nuclear distribution

Riera

Lazo

2009

Cell. Mol. Life Sci.

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Nuclear distribution gene C homolog (NudC) is a highly conserved gene. It has been identified in different species from fungi to mammals. The high degree of conservation, in special in the nudC domain, suggests that they are genes with essential functions. Most of the identified genes in the family have been implicated in cell division through the regulation of cytoplasmic dynein. As for mammalian genes, human NUDC has been implicated in the migration and proliferation of tumor cells and has therefore been considered a possible therapeutic target. There is evidence suggesting that mammalian NudC is also implicated in the regulation of the inflammatory response and in thrombopoiesis. The presence of these other functions not related to the interaction with molecular motors agrees with that these genes and their products are larger in size than their microbial orthologous, indicating that they have evolved to convey additional features.

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“…Emerging evidence has indicated that NudC may be involved in carcinogenesis (Miller et al, 1999;Lin et al, 2004;Hatakeyama et al, 2006;Suzuki et al, 2007;Hartmann et al, 2008). NudC is highly expressed in early myeloid and erythroid precursors and declines as these cells terminally differentiate (Miller et al, 1999).…”

Section: Clinical Implication Of Nudc Familymentioning

confidence: 99%

“…A significant increase of NudC is observed in bone marrow aspirates from patients with acute lymphoblastic leukemia and acute myelogenous leukemia compared to that from normal donors, indicating that NudC may be associated with hematopoietic cell proliferation and leukemogenesis. NudC has also been identified as an up-regulated gene in cutaneous T-cell lymphoma (Hartmann et al, 2008). Interestingly, Hatakeyama et al find an inverse correlation between NudC expression levels and nodal metastasis in esophageal cancer by using a comprehensive and quantitative proteomic strategy (Hatakeyama et al, 2006).…”

Section: Clinical Implication Of Nudc Familymentioning

confidence: 99%

Emerging roles of NudC family: from molecular regulation to clinical implications

Wang

Zhou

et al. 2016

Sci. China Life Sci.

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Nuclear distribution gene C (NudC) was first found in Aspergillus nidulans as an upstream regulator of NudF, whose mammalian homolog is Lissencephaly 1 (Lis1). NudC is conserved from fungi to mammals. Vertebrate NudC has three homologs: NudC, NudC-like protein (NudCL), and NudC-like protein 2 (NudCL2). All members of the NudC family share a conserved p23 domain, which possesses chaperone activity both in conjunction with and independently of heat shock protein 90 (Hsp90). Our group and the others found that NudC homologs were involved in cell cycle regulation by stabilizing the components of the LIS1/dynein complex. Additionally, NudC plays important roles in cell migration, ciliogenesis, thrombopoiesis, and the inflammatory response. It has been reported that NudCL is essential for the stability of the dynein intermediate chain and ciliogenesis via its interaction with the dynein 2 complex. Our data showed that NudCL2 regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. The fourth distantly related member of the NudC family, CML66, a tumor-associated antigen in human leukemia, contains a p23 domain and appears to promote oncogenesis by regulating the IGF-1R-MAPK signaling pathway. In this review, we summarize our current knowledge of the NudC family and highlight its potential clinical relevance.nuclear distribution gene C, heat shock protein 90, p23, dynein, Lissencephaly 1, cell cycle, ciliogenesis

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Identification of selectively expressed genes and antigens in CTCL

Cited by 27 publications

References 58 publications

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC

The mammalian NudC-like genes: a family with functions other than regulating nuclear distribution

Emerging roles of NudC family: from molecular regulation to clinical implications

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