Identification of Single Nucleotide Polymorphisms in Porcine MAOA Gene Associated with Aggressive Behavior of Weaned Pigs after Group Mixing

Chen, Ruonan; Chu, Qingpo; Shen, Chunyan; Tong, Xiao Yan; Gao, Siyuan; Liu, Xinpeng; Zhou, Bo; Schinckel, A. P.

doi:10.3390/ani9110952

Cited by 12 publications

(9 citation statements)

References 37 publications

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“…Of interest is the group of genes associated with behaviour that were grouped into two clusters by the protein–protein interaction analysis (Figure S1). On OAR27 (between 31.28 and 32.18 Mb) map MAOA and MAOB genes, both associated with aggressive behaviour in cattle, sheep, and pigs (Alvarenga et al., 2021; Chen et al., 2019; Eusebi et al., 2020). The MAOB gene was also related to dairy temperament in cattle (Macleod et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Unravelling the effect of environment on the genome of Sarda breed ewes using Runs of Homozygosity

Cesarani

Gaspa

Correddu

et al. 2022

J Animal Breeding Genetics

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Natural adaptation and artificial selection have shaped the genome of modern livestock breeds. Among SNP‐based metrics that are used to detect signatures of selection at genome‐wide level, runs of homozygosity (ROH) are getting increasing popularity. In this paper, ROH distribution and features of a sample of 823 Sarda breed ewes farmed at different levels of altitude are analysed to investigate the effect of the environment on the patterns of homozygosity. A total of 46,829 (33,087 unique) ROH were detected. OAR2 exhibited the largest average number of ROH per animal. The most frequent ROH (OAR27, 38.9–44.2 Mb) was shared by 327. ROH length was statistically affected (p < 0.001) by both the altitude and temperature of the place where the flock was located. The highest probability of a SNP falling in a ROH was observed for hill ewes, whereas the smallest one for mountain. A total of 457 SNP exceeded the 99th percentile of the ROH count per SNP distribution and were considered significant. These markers mapped in eight chromosomes and they clustered into 17 ROH islands, where 80 candidate genes were mapped. Results of this study highlighted differences in the ROH distribution and features among sheep farmed in flocks located at different levels of altitude, confirming the role of environmental adaptability in shaping the genome of this breed.

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Section: Discussionmentioning

confidence: 99%

Unravelling the effect of environment on the genome of Sarda breed ewes using Runs of Homozygosity

Cesarani

Gaspa

Correddu

et al. 2022

J Animal Breeding Genetics

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“…As far as aggressive behavior is concerned, whole genome studies are scarce in pigs [ 80 , 81 ] as well as exploration of candidate genes or genomic markers [ 82 , 83 , 84 , 85 , 86 ]. Wurtz et al [ 81 ] evidenced only one region on chromosome 11 for skin lesions that need to be confirmed.…”

Section: Perspectivesmentioning

confidence: 99%

How to Improve Meat Quality and Welfare in Entire Male Pigs by Genetics

Larzul

2021

Animals

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Giving up surgical castration is desirable to avoid pain during surgery but breeding entire males raises issues on meat quality, particularly on boar taint, and aggression. It has been known for decades that boar taint is directly related to sexual development in uncastrated male pigs. The proportion of tainted carcasses depends on many factors, including genetics. The selection of lines with a low risk of developing boar taint should be considered as the most desirable solution in the medium to long term. It has been evidenced that selection against boar taint is feasible, and has been set up in a balanced way in some pig populations to counterbalance potential unfavorable effects on reproductive performances. Selection against aggressive behaviors, though theoretically feasible, faces phenotyping challenges that compromise selection in practice. In the near future, new developments in modelization, automatic recording, and genomic data will help define breeding objectives to solve entire male meat quality and welfare issues.

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“…The promoter is a key component of genes, controlling the initiation location and expression abundance of the gene [ 53 ]. We demonstrated that the core promoter region of DRD2 gene is located in a transcription activator binding region from −2212 to −1127 bp.…”

Section: Discussionmentioning

confidence: 99%

Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs

Zhao

Gao

Guo

et al. 2022

Biology

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Aggressive behavior has negative effects on animal welfare and growth performance in pigs. The dopamine receptor D2 (DRD2) has a critical neuromodulator role in the dopamine signal pathway within the brain to control behavior. A functional single-nucleotide polymorphism (SNP), rs1110730503, in the promoter region of the porcine DRD2 gene was identified, which affects aggressive behavior in pigs. A chromatin immunoprecipitation (ChIP) assay was used to identify the interactions between interferon regulatory factor 1 (IRF1) and IRF2 with the DRD2 gene. The overexpression or knockdown of these two transcription factors in porcine kidney-15 (PK15) and porcine neuronal cells (PNCs) indicate that the binding of IRF1 to DRD2 promotes the transcription of the DRD2 gene, but the binding of IRF2 to the DRD2 gene inhibits its transcription. Furthermore, IRF1 and IRF2 are functionally antagonistic to each other. The downregulation of DRD2 or upregulation of IRF2 increased the apoptosis rate of porcine neuroglial cells. Taken together, we found that transcriptional factors IRF1 and IRF2 have vital roles in regulating the transcription of the DRD2 gene, and rs1110730503 (−915A/T) is a functional SNP that influences IRF2 binding to the promoter of the DRD2 gene. These findings will provide further insight towards controlling aggressive behavior in pigs.

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Identification of Single Nucleotide Polymorphisms in Porcine MAOA Gene Associated with Aggressive Behavior of Weaned Pigs after Group Mixing

Cited by 12 publications

References 37 publications

Unravelling the effect of environment on the genome of Sarda breed ewes using Runs of Homozygosity

Unravelling the effect of environment on the genome of Sarda breed ewes using Runs of Homozygosity

How to Improve Meat Quality and Welfare in Entire Male Pigs by Genetics

Functionally Antagonistic Transcription Factors IRF1 and IRF2 Regulate the Transcription of the Dopamine Receptor D2 Gene Associated with Aggressive Behavior of Weaned Pigs

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