Identification of Subgingival Periodontal Pathogens and Association with the Severity of Periodontitis in Patients with Chronic Kidney Diseases: A Cross-Sectional Study

Ismail, Fidan Bahtiar; Ismail, Gener; Dumitriu, Anca Silvia; Baston, C.; Berbecar, Vlad; Jurubiță, Roxana; Andronesi, Andreea; Dumitriu, H; Sinescu, I.

doi:10.1155/2015/370314

Cited by 23 publications

(28 citation statements)

References 44 publications

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“…A total of 2,763 studies were identified from Medline and Scopus, and 1,934 studies remained after removing duplicates. Of these, 1,878 studies were ineligible for reasons described in Figure , leaving 56 that were eligible for review. Six studies were excluded because of insufficient data after contacting the authors.…”

Section: Resultsmentioning

confidence: 99%

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The association between oral hygiene and periodontitis: a systematic review and meta-analysis

Lertpimonchai

Rattanasiri

Vallibhakara

et al. 2017

International Dental Journal

239

185

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ObjectiveDental plaque accumulation and inadequate personal oral hygiene (OH) are known major risk factors of periodontitis. Nevertheless, the magnitude of their effects has not yet been the subject of a meta‐analysis.Material and methodsThe Medline and Scopus databases were searched up to May 2016. Observational studies were eligible if they assessed associations between OH and periodontitis in adult subjects. A multivariate random‐effects meta‐analysis was used to pool the effects of fair/poor OH versus good OH on periodontitis across studies. The associations between oral care habits and periodontitis were also assessed.ResultsA total of 50 studies were eligible; 15 were used for pooling the effect of fair OH versus good OH and poor OH versus good OH on periodontitis, with pooled odds ratios (ORs) of 2.04 [95% confidence interval (CI): 1.65–2.53] and 5.01 (95% CI: 3.40–7.39), respectively. Eleven studies examined oral care habits measured according to toothbrushing regularity and dental visit frequency; pooled ORs of 0.66 (95% CI: 0.47–0.94) and 0.68 (95% CI: 0.47–0.98) were obtained, respectively.ConclusionsFair to poor OH increases the risk of periodontitis by two‐ to five‐fold. This risk can be reduced by regular toothbrushing and dental visits.

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Section: Resultsmentioning

confidence: 99%

“…Of these, 1,878 studies were ineligible for reasons described in Figure , leaving 56 that were eligible for review. Six studies were excluded because of insufficient data after contacting the authors. Of the remaining 50 studies, 45 objectively assessed OH using an oral examination.…”

Section: Resultsmentioning

confidence: 99%

The association between oral hygiene and periodontitis: a systematic review and meta-analysis

Lertpimonchai

Rattanasiri

Vallibhakara

et al. 2017

International Dental Journal

239

185

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“…Table describes the characteristics of 7 case‐control studies and 38 cross‐sectional studies on the non‐directional association, and lists them in reverse publication order . Among them, 24 had a statistical analysis, but 7 did not consider any confounding factors (Appendix A) .…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the various demographic characteristics of the recruited subjects in each study may have an impact on the results of this systematic review (Table ). First, the age range and number of remaining teeth of the participants vary widely. The lower number of teeth may reflect poorer periodontal status in some degree.…”

Section: Discussionmentioning

confidence: 99%

The directional and non‐directional associations of periodontitis with chronic kidney disease: A systematic review and meta‐analysis of observational studies

Zhao

Khawaja

Jin

et al. 2018

J of Periodontal Research

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This systematic review aimed to assess the current evidence on the directional and non-directional associations of periodontitis with chronic kidney disease (CKD). Electronic search for observational studies on the association of periodontitis with CKD was performed in MEDLINE, EMBASE, PubMed, Open GREY and Cochrane library up to June 5, 2017. Two reviewers conducted study selection, data collection and assessment of methodological quality using the original and modified Newcastle-Ottawa Scale. Cohort, case-control and cross-sectional studies were included, which clearly defined periodontitis and CKD or reported acceptable clinical parameters of these 2 diseases in adults. Meta-analysis was employed to estimate the pooled odds ratio on the non-directional association and the incidence rate ratio (IRR) for the directional association. Among 2530 potential eligible articles, 47 were finally included. Most of them investigated a non-directional association of periodontitis with CKD, including 7 case-control studies and 38 cross-sectional studies; 24 studies had statistical analysis on the non-directional association and 75% of them reported significant results, which were supported further by the meta-analysis (random: odds ratio = 2.12, P < .001; χ = 25.74, I = 88.3%). None of the studies focused on the directional association of CKD (as the exposure) with periodontitis (as the outcome), whereas 2 retrospective cohort studies explored a directional association of periodontitis (as the exposure) with CKD (as the outcome) (random: IRR=2.10, P > .05; fixed: IRR=1.76, P < .05; χ = 4.65, I = 78.3%). Overall, the high heterogeneity of studies limits the significance of these results. There is substantial evidence on the non-directional association of periodontitis with CKD, while there are limited studies on the directional association. Well-designed prospective studies with longer follow-ups in representative communities are needed to clarify the directional association and enhance the quality of the evidence on this topic.

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“…If in the healthy individuals, the oral biofilms are comprised mainly of gram-positive facultative anaerobes (Streptococcus anginosus and A. naeslundii), in the above mentioned pathologic conditions, the percentage of gram-negative anaerobic bacteria increases and may include Aggregatibacter (previously Actinobacillus) actinomycetemcomitans, Porphyromonas gingivalis, P. intermedia, Bacteroides forsythus, Campylobacter rectus, Eikenella sp., Peptostreptococcus micros, Streptococcus intermedius, Prevotella sp., Fusobacterium sp., Capnocytophaga sp., Veillonella sp., Treponema and other on-cultivable spirochetes, and the bacterial counts associated with the disease are up to 10(5) times larger than those of the same species found in healthy individuals [6,7].…”

Section: Introductionmentioning

confidence: 86%

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

Lazăr¹,

Dițu²,

Curuţiu³

et al. 2017

Periodontitis - A Useful Reference

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Oral cavity represents an ideal environment for the microbial cell growth, persistence, and dental plaque establishment. The presence of different microniches leads to the occurrence of different biofilm communities, formed on teeth surface, above gingival crevice or at subgingival level, on tongue, mucosa and dental prosthetics too. The healthy state is regulated by host immune system and interactions between microbial community members, maintaining the predominance of "good" microorganisms. When the complexity and volume of biofilms from the gingival crevice increase, chronic pathological conditions such as gingivitis and periodontitis can occur, predisposing to a wide range of complications. Bacteria growing in biofilms exhibit a different behavior compared with their counterpart, respectively planktonic or free cells. There have been described numerous mechanisms of differences in antibiotic susceptibility of biofilm embedded cells. Resistance to antibiotics, mediated by genetic factors or, phenotypical, due to biofilm formation, called also tolerance, is the most important cause of therapy failure of biofilm-associated infections, including periodontitis; the mechanisms of tolerance are different, the metabolic low rate and cell's dormancy being the major ones. The recent progress in science and technology has made possible a wide range of novel approaches and advanced therapies, aiming the efficient management of periodontal disease.

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Identification of Subgingival Periodontal Pathogens and Association with the Severity of Periodontitis in Patients with Chronic Kidney Diseases: A Cross-Sectional Study

Cited by 23 publications

References 44 publications

The association between oral hygiene and periodontitis: a systematic review and meta-analysis

The association between oral hygiene and periodontitis: a systematic review and meta-analysis

The directional and non‐directional associations of periodontitis with chronic kidney disease: A systematic review and meta‐analysis of observational studies

Impact of Dental Plaque Biofilms in Periodontal Disease: Management and Future Therapy

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