Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides

Aye, Racheal; Weldearegay, Yenehiwot Berhanu; Lutta, Harrison O.; Chuma, F.; Pich, Andreas; Jores, Joerg; Meens, Jochen; Naessens, Jan

doi:10.1016/j.vetimm.2018.09.002

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…Also, polyclonal rabbit serum against recombinant MSC_0267 blocked the adhesion of Mmm to BoLEC by 41%. Further in vivo studies are required for exploring the immune response induced by Mmm antigens recognized by these antibodies (Aye et al, 2018). A precision-cut lung slices (PCLS) infection model for Mmm has been established to study host-pathogen interactions.…”

Section: Adhesion and Host Immune Responsementioning

confidence: 99%

Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives

Dawood

Algharib

Zhao

et al. 2022

Front. Cell. Infect. Microbiol.

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Mycoplasmas as economically important and pantropic pathogens can cause similar clinical diseases in different hosts by eluding host defense and establishing their niches despite their limited metabolic capacities. Besides, enormous undiscovered virulence has a fundamental role in the pathogenesis of pathogenic mycoplasmas. On the other hand, they are host-specific pathogens with some highly pathogenic members that can colonize a vast number of habitats. Reshuffling mycoplasmas genetic information and evolving rapidly is a way to avoid their host’s immune system. However, currently, only a few control measures exist against some mycoplasmosis which are far from satisfaction. This review aimed to provide an updated insight into the state of mycoplasmas as pathogens by summarizing and analyzing the comprehensive progress, current challenge, and future perspectives of mycoplasmas. It covers clinical implications of mycoplasmas in humans and domestic and wild animals, virulence-related factors, the process of gene transfer and its crucial prospects, the current application and future perspectives of nanotechnology for diagnosing and curing mycoplasmosis, Mycoplasma vaccination, and protective immunity. Several questions remain unanswered and are recommended to pay close attention to. The findings would be helpful to develop new strategies for basic and applied research on mycoplasmas and facilitate the control of mycoplasmosis for humans and various species of animals.

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Section: Adhesion and Host Immune Responsementioning

confidence: 99%

Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives

Dawood

Algharib

Zhao

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Mathematical models have been developed to evaluate economic impact, transmission dynamics, and the potential impact of various control strategies [256,274,[279][280][281][282][283]. In vitro models utilizing bovine lung epithelial cells and a variety of assays have been described [240,284,285]. Bovine respiratory explants from trachea, bronchi and lungs of slaughtered cattle are a promising ex vivo tool for further investigation of CBPP infection [286].…”

Section: Contagious Bovine Pleuropneumoniamentioning

confidence: 99%

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

Clemmons

Alfson

Dutton

2021

Animals

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Animals provide food and other critical resources to most of the global population. As such, diseases of animals can cause dire consequences, especially disease with high rates of morbidity or mortality. Transboundary animal diseases (TADs) are highly contagious or transmissible, epidemic diseases, with the potential to spread rapidly across the globe and the potential to cause substantial socioeconomic and public health consequences. Transboundary animal diseases can threaten the global food supply, reduce the availability of non-food animal products, or cause the loss of human productivity or life. Further, TADs result in socioeconomic consequences from costs of control or preventative measures, and from trade restrictions. A greater understanding of the transmission, spread, and pathogenesis of these diseases is required. Further work is also needed to improve the efficacy and cost of both diagnostics and vaccines. This review aims to give a broad overview of 17 TADs, providing researchers and veterinarians with a current, succinct resource of salient details regarding these significant diseases. For each disease, we provide a synopsis of the disease and its status, species and geographic areas affected, a summary of in vitro or in vivo research models, and when available, information regarding prevention or treatment.

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“…120 However, current data indicate that the adhesion of respiratory mycoplasmas is a more complex and multistep process, which reasonably involve both specific (ie, ligandreceptor interactions) and nonspecific (hydrophobic interactions) mechanisms. 8 Mycoplasmas have long been considered extracellular parasites, strictly adhering to the host cell membrane to acquire nutrients. However, this dogma has been largely disavowed, thanks to the development of suitable in vitro models of study and more sophisticated microscopic technologies.…”

Section: Adhesion To and Invasion Of The Host's Cells And Tissuesmentioning

confidence: 99%

“…Recent evidence indicates that Mmm adhesion molecules are immunogenic, as the organism attachment is inhibited by immune sera. 8,28 Unlike other mycoplasmas, the capsular galactan (a polysaccharide made of 6-O-b-D-galactofuranosyl-D-galactose) seems to reduce the attachment of Mmm to host cells, probably masking the adhesion molecules that become less exposed to the immune system. 93 A protein ("P19") has also been suggested to contribute to Mmm adhesion in vitro.…”

Section: Adhesion To and Invasion Of The Host's Cells And Tissuesmentioning

confidence: 99%

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Contagious Bovine Pleuropneumonia: A Comprehensive Overview

et al. 2020

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Contagious bovine pleuropneumonia (CBPP) is a respiratory disease of cattle that is listed as notifiable by the World Organization for Animal Health. It is endemic in sub-Saharan Africa and causes important productivity losses due to the high mortality and morbidity rates. CBPP is caused by Mycoplasma mycoides subsp. mycoides ( Mmm) and is characterized by severe fibrinous bronchopneumonia and pleural effusion during the acute to subacute stages and by pulmonary sequestra in chronic cases. Additional lesions can be detected in the kidneys and in the carpal and tarsal joints of calves. Mmm infection occurs through the inhalation of infected aerosol droplets. After the colonization of bronchioles and alveoli, Mmm invades blood and lymphatic vessels and causes vasculitis. Moreover, Mmm can be occasionally demonstrated in blood and in a variety of other tissues. In the lung, Mmm antigen is commonly detected on bronchiolar and alveolar epithelial cells, in lung phagocytic cells, within the wall of blood and lymphatic vessels, inside necrotic areas, and within tertiary lymphoid follicles. Mmm antigen can also be present in the cytoplasm of macrophages within lymph node sinuses, in the germinal center of lymphoid follicles, in glomerular endothelial cells, and in renal tubules. A complete pathological examination is of great value for a rapid presumptive diagnosis, but laboratory investigations are mandatory for definitive diagnosis. The purpose of this review is to describe the main features of CBPP including the causative agent, history, geographic distribution, epidemiology, clinical course, diagnosis, and control. A special focus is placed on gross and microscopic lesions in order to familiarize veterinarians with the pathology and pathogenesis of CBPP.

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Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides

Cited by 7 publications

References 47 publications

Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives

Mycoplasmas as Host Pantropic and Specific Pathogens: Clinical Implications, Gene Transfer, Virulence Factors, and Future Perspectives

Transboundary Animal Diseases, an Overview of 17 Diseases with Potential for Global Spread and Serious Consequences

Contagious Bovine Pleuropneumonia: A Comprehensive Overview

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