Objective. The process of designing a long-range aircraft, in particular at the preliminary design stage, involves comparing and analyzing a large number of design alternatives with specified performance criteria. At the same time, the problem of choosing the composition of rational design parameters is solved, which is an actual problem of the preliminary design stage of a long-range aircraft. Methods. The developed method allows determining the vector of parameters that provides rational characteristics for a given efficiency criterion. In this regard, the authors propose to introduce a global efficiency criterion - the takeoff weight of the long-range aircraft, and the specific criteria are the aerodynamic quality in cruise and the value of fuel efficiency. Results. In this formulation of the design problem, it is necessary to solve several interrelated problems, some of which are formalized, while others do not yet have a mathematical construct and software that allows automating the process. A distinctive feature of the proposed approach to finding a rational design solution is the use of statistical analysis methods in combination with methods of high-precision mathematical modeling, software-implemented in a single information environment using the Fortran V and C++ languages. Conclusion. The proposed method for selecting the composition of rational design parameters allows forming the appearance and providing the specified characteristics for its component elements at the early stages and stages of designing the long-range aircraft.