Identification of the Chemical Compound of Essential Oil from Ketumbar (Coriandrum sativum L.) Leaves with Gc-Ms

Abstract

Ketumbar (Coriandrum sativum L.) is a plant that is widely used as a spice, especially in cooking spices. This plant has a distinctive aroma. The distinctive aroma that is owned because this plant contains essential oils. 1 Phytochemical screening results of coriander seeds have diverse secondary metabolites, including steroids, flavonoids, saponins, tannins, coumarin, 2 volatile compounds 3 and coriander leaves are contain phenolic acid, poliyphenols, glycosides, saponins, flavonoids and tannins. 4,5 These coriander plants have diverse biology activities including antioxidant, 6 antimicrobial, hypoglycemic, hypolipidemic, anxiolytic, analgesic, anti-inflammatory, anti-convulsant 3 and anti-cancer activities and gastrointestinal, antiinflammatory, antiseptic, tranquilizing nervous system, lipolytic and miorelaksan, rerigeran, tonic, dieretic, rheumatic, neuralgia, and flatulence 7 and antimicrobials. 8 This study aims to characterize, isolate essential oils and analyze the content of bioactive compounds of C. sativum leaves using Gas Chromatography-Mass Spectrocopy (GC-MS). MATERIALS AND METHODS Preparation sampleFresh of ketumbar (C. sativum) leaves were obtained from the Berastagi area, Karo district, North Sumatera, Indonesia. The C. sativum leaves is authorized by the Indonesian scientific institution: Biology Research Center (3533/MEDA/2019). Samples are cleaned in running water, drained, and dried in open spaces which avoid direct contact with sunlight. The dried sample was mashed using a blender to obtain the simplicia powder of C. sativum leaves. Preparation of isolation essential oil of C. sativum leavesIsolation of essential oils of simplicia of C. sativum leaves was carried out by means of modified distillation (Figure 1). Simplisia C. sativum leaves are put into a round pumpkin, plus boiling stones and distilled water to taste. The distillation process is carried out for 1-2 days per 500 g simplicia of C.

Construction of network pharmacology-based approach and potential mechanism from major components of Coriander sativum L. against COVID-19

“…As a result of our earlier investigation and literature searching, we were able to identify a total of nine major chemicals in CSL (Table 1) (Gurning et al 2020;Satyal and Setzer 2020). The GeneCards database was searched for targets linked to COVID-19, and the results revealed that there were 4,585 targets connected to COVID-19 and a total of 195 possible targets of 9 active compounds of CSL.…”

“…According to International Organization of Standards (1998) and Guring et al (2020), CSL contain several essential oil such as linalool, limonene, α-pinene, geraniol, and α-terpineol. All of these active compounds from CSL have shown abundant health benefits (Gurning et al 2020).…”

Untitled

“…Coriander (Coriandrum sativum) [64][65][66] Reduction in arterial blood pressure of anesthetized animals have been noted at dose 1-30 mg/ml crude extract -Ca 2+ channel blocking and cholinergic property.…”