Identification of the gene locus controlling dominant nonresponsiveness to F-antigen

Silver, Donald M.; Lane, David P.

doi:10.1007/bf01575668

Cited by 22 publications

(7 citation statements)

References 9 publications

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“…A gene controlling the antibody level to G(B1O.A) was mapped to the K end of the H-2 complex. The absence of cytotoxic antibodies in the sera of (BlO.AV+ X BlOV+)F,, H-2'Ib-typed (BlO.AV+ X B10V+)F2 animals and in sera of (BlO.AV+ (Silver and Lane, 1977;Wicker and Hildemann, 1981). Recently, Sandrin et al (1981) reported that the I-Ak gene (or genes) regulate the expression of Ia.8 and Ia.9 specificities, which are coded for by the the I-A gene.…”

Section: Discussionmentioning

confidence: 95%

“…The absence of cytotoxic antibodies in the sera of (BlO.AV+ X BlOV+)F,, H-2'Ib-typed (BlO.AV+ X B10V+)F2 animals and in sera of (BlO.AV+ At present, it is not known whether the G(B10,A) expression in BIO.A mice is H-2 determined nor at which time the G(B1O.A) antigen becomes expressed in BIO.A mice. Although most of the Ir-gene effects are dominant, recessive inheritance of responsiveness has been reported with other antigens (Silver and Lane, 1977;Wicker and Hildemann, 1981). Recently, Sandrin et al (1981) reported that the I-Ak gene (or genes) regulate the expression of Ia.8 and Ia.9 specificities, which are coded for by the the I-A gene.…”

Section: Discussionmentioning

confidence: 99%

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H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G_(B10.A)

Vlug

Zijlstra

Degoede

et al. 1983

Intl Journal of Cancer

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H-2-congeneic C57BL mice with milk transmission of B-tropic murine leukemia virus (V+ mice) have a much higher lymphoma incidence than the same strains without milk-transmitted virus (V- mice). Gene(s) within the major histocompatibility complex (H-2) influence virus titers, lymphoma incidence, lymphoma type and the anti-MuLV envelope antibody response. In this paper, we report that the prevalence of cytotoxic antibodies to virus-induced lymphomas is also regulated by the H-2 complex. Milk transmission of MuLV resulted in the formation of cytotoxic antibodies against primary virus-induced C57BL lymphomas. These antibodies detect an antigen that is also present on the RADAI tumor-cell line, and on normal spleen cells of young adult B10.A (H-2a) mice of both V+ and V- sublines, but not on spleen cells of young adult B10 (H-2a) mice of either subline. These cytotoxic antibodies were detected in the sera of B10V+ and B10.A(5R)V+ animals, but not in the sera of B10.AV+ mice. This indicates that the prevalence of these antibodies is controlled by a gene in the K- and/or I-A region of the H-2 complex. The presence of these cytotoxic antibodies in serum is recessively inherited. The specificity of the cytotoxic antibodies was investigated with a standard panel of transplantable tumor-cell lines. Of these, only the RADAI cells expressed the target antigen in direct cytotoxicity tests and by absorption. The ability of B10V+ sera to lyse the B10.AV+ and RADAI tumor cells is ascribed to antibody activity against a new MuLV-related cell-surface protein: G(B10.A). Immunochemical analysis and absorption experiments with different types of purified MuLV and MuLV-infected cell lines indicate that the cytotoxic antibodies belong to low-avidity IgM antibodies that are directed to MuLV.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G_(B10.A)

Vlug

Zijlstra

Degoede

et al. 1983

Intl Journal of Cancer

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“…The counteracting role of non-H-2 loci in such a mechanism, which is implied by the efficacy of the anti-TATA immunity in both CAK and CBR mice, remains to be elucidated. However, several examples are available to elucidate the possible non-MHC genetic control of the expression of MHC-encoded cell recognition, of interaction molecules (Rich et al 1977), and of MHC-encoded suppressor functions (Albright et al 1977, Meruelo et al 1977, Silver and Lane 1977. It should be noted that the TATA involved in the present study is a unique antigenic structure, cross-reacting with the TATA of only one out of five other C sarcomas of the same etiology (Meschini et al 1977).…”

mentioning

confidence: 88%

Genetic control of responsiveness to the tumor-associated transplantation antigen of a chemically induced murine fibrosarcoma

Parmiani

1978

Immunogenetics

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“…I t has recently been shown that in order to respond to the liver-specific alloantigen, Fantigen, mice must possess a k-allele at H-2K or I-A (Silver & Lane 1977). A number of strains bearing a variety of H-2 haplotypes were tested for their ability to respond to type-1 or type 2 F-antigen.…”

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confidence: 99%

Identification of an Antigen Shared by Mouse Liver and Lung

Silver

1979

Tissue Antigens

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In response to multiple injections of liver extract from Balb/c mice, DBA/1 mice produce antibodies against a component of the liver preparation which is not F‐antigen, but which is able to precipitate in gel diffusion tests. This antigen is also found in extracts of Balb/c lung, but not in a variety of other organs tested. Liver extracts from all of the inbred strains studied contain the antigen, except extracts from DBA/1 mice. Furthermore, this antigen was not found in the liver or lungs of other vertebrates tested. The antigen has been designated antigen‐L1.

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Identification of the gene locus controlling dominant nonresponsiveness to F-antigen

Cited by 22 publications

References 9 publications

H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G_(B10.A)

H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G_(B10.A)

Genetic control of responsiveness to the tumor-associated transplantation antigen of a chemically induced murine fibrosarcoma

Identification of an Antigen Shared by Mouse Liver and Lung

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Identification of the gene locus controlling dominant nonresponsiveness to F-antigen

Cited by 22 publications

References 9 publications

H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G(B10.A)

H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G(B10.A)

Genetic control of responsiveness to the tumor-associated transplantation antigen of a chemically induced murine fibrosarcoma

Identification of an Antigen Shared by Mouse Liver and Lung

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H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G_(B10.A)

H‐2 control of the cytotoxic antibody response against a newly defined MuLV‐related cell‐surface antigen: G_(B10.A)