Identification of the Variations in the <i>CPT1B</i> and <i>CHKB</i> Genes Along with the HLA-DQB1*06:02 Allele in Turkish Narcolepsy Patients and Healthy Persons

Cingoz, Sultan; Agilkaya, Sinem; Öztura, İbrahim; Eroğlu, Secil; Karadeniz, Derya; Evlice, Ahmet; Altungoz, Oguz; Yılmaz, Hikmet; Baklan, Barış

doi:10.1089/gtmb.2013.0391

Cited by 9 publications

(2 citation statements)

References 41 publications

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“…The CHKB gene is transcribed from the same DNA strand and terminates upstream of CPT1B ( 36 ). The tight combination of CHKB - CPT1B may overlap the cis-action regulatory domains and realise a common regulatory mechanism ( 37 ). Mierxiati Abudurexiti’s study has confirmed that CTP1B expression is upregulated in prostate cancer ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Multiple databases analyzed the prognosis prediction of renin secretion pathway-related genes in renal clear cell carcinoma and immunotherapy

Li,

Bao,

Xiao

et al. 2024

Transl Cancer Res

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Background Clear cell renal cell carcinoma (ccRCC) is a malignant kidney tumour and its progression is associated with the renin secretion pathway, so this study aimed to develop a prognostic model based on renin secretion pathway-related genes. Methods First, 453 renin secretion pathway-related genes were acquired [|log fold change (FC)| >1.5, false discovery rate (FDR) <0.05] from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. The data were combined and further screened for 188 genes associated with ccRCC prognosis (P<0.05) by univariate independent prognostic analysis. These genes were subjected to least absolute shrinkage and selection operator regression to identify potential prognostic genes to construct the prognostic model. The stability of the model was externally validated. Combined risk scores and clinical information were used to create nomograms to accurately reflect patient survival. The model-related genes were further mined for subsequent analysis. Results A prognostic model of six renin secretion pathway genes ( IGFBP3 , PLAUR , CHKB-CPT1B , HOXA13 , CDH13 , and CDC20 ) was developed. Its reliability in predicting disease prognosis was confirmed by survival analysis, receiver operating characteristic (ROC) curve analysis and a risk curve. The nomogram and calibration curve showed good accuracy. The immune-related analyses revealed that the low-risk group would benefit more from immunotherapy. Conclusions The prognostic model of ccRCC based on six renin secretion pathway-related genes can be used to guide the precise treatment of ccRCC patients.

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Section: Discussionmentioning

confidence: 99%

Multiple databases analyzed the prognosis prediction of renin secretion pathway-related genes in renal clear cell carcinoma and immunotherapy

Li,

Bao,

Xiao

et al. 2024

Transl Cancer Res

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show abstract

“…A latest finding shows that lower expression of CPT1B inhibits breast cancer stem cell survival (Wang et al, 2017). Other studies on CPT1B are mainly related to the regulation of rapid eye movement sleep and body weight (Cingoz et al, 2014;Ka et al, 2013). Moreover, CPT1B is important to hibernators for energy metabolism due to its higher protein expression in brown fat during hibernation (Eddy, Morin, & Storey, 2006).…”

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confidence: 99%

Effects of carnitine palmitoyltransferases on cancer cellular senescence

Guan

Chen

Wang

et al. 2018

Journal Cellular Physiology

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The carnitine palmitoyltransferase (CPT) family is essential for fatty acid oxidation. Recently, we found that CPT1C, one of the CPT1 isoforms, plays a vital role in cancer cellular senescence. However, it is unclear whether other isoforms (CPT1A, CPT1B, and CPT2) have the same effect on cellular senescence. This study illustrates the different effects of CPT knockdown on PANC-1 cell proliferation and senescence and MDA-MB-231 cell proliferation and senescence, as demonstrated by cell cycle kinetics, Bromodeoxyuridine incorporation, senescence-associated β-galactosidase activity, colony formation, and messenger RNA (mRNA) expression of key senescence-associated secretory phenotype factors. CPT1C exhibits the most substantial effect on cell senescence. Lipidomics analysis was performed to further reveal that the knockdown of CPTs changed the contents of lipids involved in mitochondrial function, and lipid accumulation was induced. Moreover, the different effects of the isoform deficiencies on mitochondrial function were measured and compared by the level of radical oxygen species, mitochondrial transmembrane potential, and the respiratory capacity, and the expression of the genes involved in mitochondrial function were determined at the mRNA level. In summary, CPT1C exerts the most significant effect on mitochondrial dysfunction-associated tumor cellular senescence among the members of the CPT family, which further supports the crucial role of CPT1C in cellular senescence and suggests that inhibition of CPT1C may represent as a new strategy for cancer treatment through the induction of tumor senescence.

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Choline kinases: Enzymatic activity, involvement in cancer and other diseases, inhibitors

Korbecki,

Bosiacki,

Kupnicka

et al. 2024

Intl Journal of Cancer

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One of the aspects of tumor metabolism that distinguish it from healthy tissue is the phosphorylation of choline by choline kinases, which initiates the synthesis of phosphatidylcholine. Presently, there is a lack of comprehensive reviews discussing the current understanding of the role of choline kinase in cancer processes, as well as studies on the anti‐tumor properties of choline kinase inhibitors. To address these gaps, this review delves into the enzymatic and non‐enzymatic properties of CHKα and CHKβ and explores their precise involvement in cancer processes, particularly cancer cell proliferation. Additionally, we discuss clinical aspects of choline kinases in various tumor types, including pancreatic ductal adenocarcinoma, ovarian cancer, lung adenocarcinoma, lymphoma, leukemia, hepatocellular carcinoma, colon adenocarcinoma, and breast cancer. We examine the potential of CHKα inhibitors as anti‐tumor drugs, although they are not yet in the clinical trial phase. Finally, the paper also touches upon the significance of choline kinases in non‐cancerous diseases.

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Identification of the Variations in the CPT1B and CHKB Genes Along with the HLA-DQB1*06:02 Allele in Turkish Narcolepsy Patients and Healthy Persons

Cited by 9 publications

References 41 publications

Multiple databases analyzed the prognosis prediction of renin secretion pathway-related genes in renal clear cell carcinoma and immunotherapy

Multiple databases analyzed the prognosis prediction of renin secretion pathway-related genes in renal clear cell carcinoma and immunotherapy

Effects of carnitine palmitoyltransferases on cancer cellular senescence

Choline kinases: Enzymatic activity, involvement in cancer and other diseases, inhibitors

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