Identification of trans-tiliroside as active principle with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinesis

Qiao, Wei; Zhao, Chuan; Qin, Nan; Zhai, Hua‐Jin; Duan, Hong

doi:10.1016/j.jep.2011.03.062

Cited by 49 publications

(18 citation statements)

References 29 publications

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“…In fact, the effects of AePF on DPPH and superoxide anion were, respectively, similar to that of the BHT, a synthetic antioxidant, and higher than quercetin, a potent natural antioxidant. These results are in accordance with previously described data for kaempferol, quercetin, and tiliroside, exhibiting important DPPH and superoxide scavenging activities [35–37]. On the other hand, weaker activities against the hydroxyl radical were observed, corroborating what is cited in literature.…”

Section: Resultssupporting

confidence: 93%

Antioxidant, Anti‐Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion

Santos

Costa

Ferreira

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Agrimony (Agrimonia eupatoria L.) (Ae) is used in traditional medicine to treat inflammatory and oxidative related diseases. Therefore, this study focuses on the anti-inflammatory and analgesic potential of Ae infusion (AeI). Phenolic compounds characterization was achieved by HPLC-PDA-ESI/MSn. To evaluate antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and SNAP assays were used. In vitro anti-inflammatory activity of AeI was investigated in LPS-stimulated macrophages by measuring the NO production. In vivo anti-inflammatory activity was validated using the mouse carrageenan-induced paw edema model. Peripheral and central analgesic potential was evaluated using the acetic acid-induced writhing and hot-plate tests, respectively, as well as the formalin assay to assess both activities. The safety profile was disclosed in vitro and in vivo, using MTT and hematoxylin assays, respectively. Vitexin, quercetin O-galloyl-hexoside, and kaempferol O-acetyl-hexosyl-rhamnoside were referred to in this species for the first time. AeI and mainly AePF (Ae polyphenolic fraction) showed a significant antiradical activity against all tested radicals. Both AeI and AePF decreased NO levels in vitro, AePF being more active than AeI. In vivo anti-inflammatory and analgesic activities were verified for both samples at concentrations devoid of toxicity. Agrimony infusion and, mainly, AePF are potential sources of antiradical and anti-inflammatory polyphenols.

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Section: Resultssupporting

confidence: 93%

Antioxidant, Anti‐Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion

Santos

Costa

Ferreira

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…As research has shown, tiliroside may exert a beneficial effect on many mechanisms of hyperglycemia or its complications. Qiao, Zhao, Qin, Zhai, and Duan () reported that tiliroside administered orally to diabetic mice and rats at concentrations from 0.4 to 1.6 mg/kg and 0.3 to 1.2 mg/kg, respectively, decreased glucose, triglyceride, total cholesterol, and low‐density lipoprotein levels. These results were obtained raising the high‐density lipoprotein level comparably or even more strongly than much higher doses of metformin (1.6 mg/kg tiliroside was as strong as 125 mg/kg metformin).…”

Section: Biological Activities Of Tilirosidementioning

confidence: 99%

A Review on the Dietary Flavonoid Tiliroside

Grochowski

Locatelli

Granica

et al. 2018

Comp Rev Food Sci Food Safe

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Among flavonoid derivatives, tiliroside is a flavonoid contained in several edible plants or specific plant parts (fruits, leaves, or roots). These parts are often widely used as both food and medicines, in the treatment of various ailments and, in some cases, as food supplements. Considering the easy access to many publications concerning tiliroside and the lack of a review that summarizes the current progress in studies on its safety, efficacy, and presence in the plant kingdom, we present here a review paper on tiliroside and its principal derivatives. The paper also highlights the basic knowledge regarding this molecule, its derivatives, and the analytical approaches used for extraction and quantification, as well as reports on the biological activities against different key enzymes linked to various human diseases. The reported information is also devoted to highlighting the concept "learn from nature to discover new products," particularly in the development of new drugs, food supplements, and nutraceuticals, starting from a natural lead compound such as tiliroside and improving its biological activities (and selectivities) against a specific target for therapeutic purposes.

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“…1), is the major component of AP extracts. Tiliroside has been reported to exhibit the following: Anti-diabetic properties by enhancing glucose consumption by insulin-resistant HepG2 cells (11,12); antihypertensive and vasorelaxant effects in resistance arteries (13); anti-hyperglycemic, anti-hyperlipidemic and antioxidant activities (14); as well as an inhibitory effect on important human liver cytochrome p450 enzymes (15). Tiliroside and two other flavonoids have been analyzed in vitro for their antioxidant properties and in vivo for their anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Tiliroside, the major component of Agrimonia pilosa Ledeb ethanol extract, inhibits MAPK/JNK/p38-mediated inflammation in lipopolysaccharide-activated RAW 264.7 macrophages

Jin

Song

Wang

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. In the present study, the in vivo anti-inflammatory activity of Agrimonia pilosa Ledeb (AP) ethanol extract was confirmed in experimental animal models, including xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. Tiliroside, the major component of AP extract, was isolated and purified by high-performance liquid chromatography. The anti-inflammatory mechanism of tiliroside was then examined using lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells. An MTT assay was used to determine cytotoxicity and a Griess assay was used to determine nitric oxide (NO) production. Concentration levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were determined by enzyme-linked immunosorbent assay. Protein expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), phosphorylated (p)-extracellular signal-regulated kinase (ERK) 1/2, p-c-Jun N-terminal kinases (JNK), p-p38 and inhibitor of κB-α were detected by western blot analysis. AP ethanol extract was revealed to inhibit xylene-induced ear edema in mice and carrageenan-induced paw edema in rats. Tiliroside significantly suppressed the overproduction of NO (P<0.01), but revealed no notable inhibition of the release of TNF-α and IL-6. In addition, tiliroside significantly downregulated the elevated expression levels of iNOS and COX-2 induced by LPS (P<0.01). The phosphorylation of JNK and p38 proteins were also significantly inhibited (P<0.01), however, tiliroside exhibited no obvious inhibition on the phosphorylation of ERK 1/2 and the degradation of IκB-α protein.In conclusion, the anti-inflammatory molecular mechanism of tiliroside may involve the downregulation of iNOS and COX-2 protein expression levels, and the inactivation of mitogen-activated protein kinase (MAPK)/JNK, in addition to the MAPK/p38 signaling pathway. IntroductionAgrimonia pilosa Ledeb (Rosaceae; AP) is a perennial herbaceous flowering plant distributed in the temperate regions of the Northern hemisphere, including Asia. As a traditional medicinal plant, it has been used for the treatment of abdominal pain, sore throat, headaches, bloody discharge, parasitic infections and eczema (1). Pharmacological research has revealed that AP extracts possess diverse pharmacological properties, including antinociceptive (1), antiplatelet (2) and antihemostatic effects (3), in addition to antioxidant (4), antiviral (5), antitumor (6), anti-inflammatory, anti-allergic (7,8), anti-microbial (9) and anti-hyperglycemic (10) activity, amongst others. Tiliroside, a glycosidic flavonoid (Fig. 1), is the major component of AP extracts. Tiliroside has been reported to exhibit the following: Anti-diabetic properties by enhancing glucose consumption by insulin-resistant HepG2 cells (11,12); antihypertensive and vasorelaxant effects in resistance arteries (13); anti-hyperglycemic, anti-hyperlipidemic and antioxidant activities (14)

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Identification of trans-tiliroside as active principle with anti-hyperglycemic, anti-hyperlipidemic and antioxidant effects from Potentilla chinesis

Cited by 49 publications

References 29 publications

Antioxidant, Anti‐Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion

Antioxidant, Anti‐Inflammatory, and Analgesic Activities of Agrimonia eupatoria L. Infusion

A Review on the Dietary Flavonoid Tiliroside

Tiliroside, the major component of Agrimonia pilosa Ledeb ethanol extract, inhibits MAPK/JNK/p38-mediated inflammation in lipopolysaccharide-activated RAW 264.7 macrophages

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