Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma

Nakamura, Naoko; Kobayashi, Kenzo; Nakamoto, Masaki; Kohno, Takashi; Sasaki, Hiroki; Matsuno, Yosuke; Yokota, Jun

doi:10.1038/sj.onc.1209442

Cited by 25 publications

(23 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, we also examined whether expression of DNTCF in H23 and H1819 cells altered their differentiation state. Real-time PCR analysis showed that induction of DN and DN-mO led to an upregulation of several differentiation markers known to be expressed in differentiated bronchiolar (Clara-cell-specific protein, CCSP) or alveolar type 2 (AT2) cells (A1AT, ICAM-1 and MUC-1) (Supplementary Figure S4; Braga et al ., 1992; Guzman et al ., 1994; Venembre et al ., 1994; Nakamura et al ., 2006). These results demonstrate that inhibition of autocrine Wnt signaling by DNTCF-4 leads to increased expression of differentiation markers associated with both alveolar (AT2) and bronchial (Clara) lineages.…”

Section: Resultsmentioning

confidence: 99%

Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma

et al. 2009

View full text Add to dashboard Cite

Lung cancer is the most common cause of cancer mortality worldwide. Non-small-cell lung carcinomas (NSCLCs), which represent around 80% of lung tumors, exhibit poor prognosis and are usually refractory to conventional chemotherapy. Elucidating the molecular and cellular mechanisms that are dysregulated in NSCLCs may lead to new possibilities for targeted therapy or enhanced efficacy of current therapies. Here we demonstrate Wnt pathway activation in around 50% of human NSCLC cell lines and primary tumors, through different mechanisms, including autocrine Wnt pathway activation involving upregulation of specific Wnt ligands. Downregulation of activated Wnt signaling inhibited NSCLC proliferation and induced a more differentiated phenotype. Together, our findings establish importance of activated Wnt signaling in human NSCLCs and offer the possibility of targeting upregulated Wnt signaling as a new therapeutic modality for this disease.

show abstract

Section: Resultsmentioning

confidence: 99%

Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Despite improvements made in detection and treatments during the past two decades, the clinical behaviors of lung adenocarcinoma remain poor, with an unsatisfactory survival of clinical patients. Up to now, there have been many diagnostic and prognostic markers identified and investigated for lung adenocarcinoma, but a useful screening marker for patients with lung adenocarcinoma has not been clearly established [18]. Therefore, the identification of new molecular prognostic and predictive markers in lung adenocarcinoma helps to exactly evaluate the prognosis of patients and add further prognostic information, select high-risk patients for aggressive adjuvant treatments and set new anticancer therapies.…”

Section: Discussionmentioning

confidence: 97%

Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma

Wang¹,

Geng²,

Wang³

et al. 2009

Lung Cancer

View full text Add to dashboard Cite

“…The FGFR3 and TTYH1 genes are already reported to be associated with bone metastasis in breast cancers (16). TM4SF4 and CRYM genes were reported as tumor markers in lung cancer (17)(18)(19). FOLR1 gene was reported to be overexpressed in lung adenocarcinoma (20,21) and has critical involvement in drug resistance (22).…”

Section: Validation Of Bone-preferentially Expressed Genesmentioning

confidence: 99%

Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile analysis of non-small cell lung cancer in mice

et al. 2012

View full text Add to dashboard Cite

Abstract. Lung cancer is commonly associated with multiorgan metastasis, and the bone is a frequent metastatic site for lung cancer. However, the molecular mechanism of organspecific metastasis remains poorly understood. To elucidate this issue, we analyzed in this study genome-wide gene expression profiles of 15 metastatic lesions from three organs (bone, lung and liver) in a mouse model with multi-organ metastasis properties of human non-small cell lung cancer cells (ACC-LC319/ bone2), using a combination of laser-microbeam microdissection and DNA microarrays. We identified 299 genes that could potentially be involved in the organ-selective nature of lung cancer metastasis. Among them, 77 were bone-specifically expressed elements, including genes involved in cell adhesion, cytoskeleton/cell motility, extracellular matrix remodeling and cell-cell signaling as well as genes already known to be involved in the bone metastasis of breast cancers. Quantitative RT-PCR confirmed the specific upregulation of eight genes in bone metastasis tumors, suggesting that these genes may be involved in bone metastasis. Our findings should be helpful for a better understanding of the molecular aspects of the metastatic process in different organs, and could lead to molecular target-based anticancer drugs and prevention of metastasis, especially bone metastasis.

show abstract

Identification of tumor markers and differentiation markers for molecular diagnosis of lung adenocarcinoma

Cited by 25 publications

References 31 publications

Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma

Wnt pathway aberrations including autocrine Wnt activation occur at high frequency in human non-small-cell lung carcinoma

Overexpression of eukaryotic initiation factor 4E (eIF4E) and its clinical significance in lung adenocarcinoma

Identification of genes potentially involved in bone metastasis by genome-wide gene expression profile analysis of non-small cell lung cancer in mice

Contact Info

Product

Resources

About