Identification of two cannabimimetic compounds WIN48098 and AM679 in illegal products

Gregori, Adolfo; Damiano, Fabio; Bonavia, Maurizio; Mileo, Valentina; Varani, Francesco; Monfreda, Maria

doi:10.1016/j.scijus.2012.10.002

Cited by 12 publications

(12 citation statements)

References 13 publications

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“…Marijuanaya benzer olmasına karşın SK'ler tetrahidrokanabiol (THC) için yapılan toksikolojik incelemelerde pozitif sonuç vermezler ayrıca günümüzde SK'lerin hiç bir kütle spektorometre sisteminde kayıtları olmadığından ve referans standartları bulunmadığından, tespit edilmeleri kolay değildir. Sentetik kannabinoidlere bağlı toksisitesinin teşhis edilmesi için, semptom ve bulguların iyi tanımlanması ve bu toksikasyondan şüphelenilmesi gerekmektedir (9,10). Sentetik kannabinoid kullanımına bağlı gelişen semptomların tedavisinin destekleyicisi olması ve ajitasyon ile anksiyetenin kontrolü için benzodiazepinlerin kullanılması önerilmiştir (11).…”

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Acil serviste yeni bir tehlike: Sentetik kannabinoidler (Bonzai, Jameika)

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2015

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Acil serviste yeni bir tehlike: Sentetik kannabinoidler (Bonzai, Jameika)

Küçük¹,

Kucuk²

2015

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“…Because of the low concentrations of NSs, the analysis of such samples demands the application of methods ensuring low limits of detection, for exam ple, HPLC-MS/MS in the mode of multiple reaction monitoring. The procedure of sample preparation is determined by the character of the sample: for hair it includes prolong (about 3 h) extraction with ethanol under ultrasonic treatment [144] or hydrolysis of a matrix in the presence of NaOH [145,148]; for saliva [110] Designations: FB is formate buffer solution; UST is ultrasonic treatment; UHPLC-MS is ultrahigh performance liquid chromatography-mass spectrometry; DAD is diode array detector; UV is ultraviolet detector; EI is electron impact ionization; ESI is electrospray ionization; Q is quadrupole mass spectrometer; TOF is time of flight mass spectrometer. (40) it includes solid phase extraction [150] or the precipi tation of proteins [155].…”

Section: Determination Of New Narcoticsmentioning

confidence: 99%

Evolution of new narcotic substances and methods of their determination

2014

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History of the appearance and evolution of synthetic narcotics in recent years is presented. The main attention is paid to two classes of narcotic substances received the widest distribution in the world, i.e., cannabimetics and synthetic cations. The main classes, problems of identification, and approaches to the determination of new narcotics are considered. Approaches and solutions used in the quantitative analysis and screening of narcotics are discussed along with some aspects of sample preparation to their determination and matrix effects. The specific features of the determination of new narcotics in commercial products and biological samples are considered separately. Present day methods of chromatography-mass spectrometry are most informative for timely revealing new narcotic substances, studying their metabolism, and developing reliable methods for the screening of native and biological samples.

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“…Sobolevsky 72 reported for the first the time, urinary metabolites of JWH-018; clearly highly useful for the analysis of patients admitted to emergency departments and for the development of point-of-care tests (see the story of the "Spice girls" earlier in this mini-review). 60,79,80 Following this pioneering work, there has been a pursuit of studying synthetic cannabinoids in urine. 72 It should be noted the parent compound (JWH-018) was reported to not be detected in urine.…”

Section: Synthetic Cannabinoidsmentioning

confidence: 99%

An overview of recent developments in the analytical detection of new psychoactive substances (NPSs)

Smith

Sutcliffe

Banks

2015

Analyst

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New psychoactive substances (NPSs), sometimes referred to as "legal highs" in more colloquial environments/the media, are a class of compounds that have been recently made available for abuse (not necessarily recently discovered) which provide similar effects to the traditional well studied illegal drugs but are not always controlled under existing local, regional or international drug legislation. Following an unprecedented increase in the number of NPSs in the last 5 years (with 101 substances discovered for the first time in 2014 alone) its, occasionally fatal, consequences have been extensively reported in the media. Such NPSs are typically marketed as 'not for human consumption' and are instead labelled and sold as plant food, bath salts as well as a whole host of other equally nondescript aliases in order to bypass legislative controls. NPSs are a new multi-disciplinary research field with the main emphasis in terms of forensic identification due to their adverse health effects, which can range from minimal to life threatening and even fatalities. In this mini-review we overview this recent emerging research area of NPSs and the analytical approaches reported to provide detection strategies as well as detailing recent reports towards providing point-of-care/in-the-field NPS ("legal high") sensors.

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Identification of two cannabimimetic compounds WIN48098 and AM679 in illegal products

Cited by 12 publications

References 13 publications

Acil serviste yeni bir tehlike: Sentetik kannabinoidler (Bonzai, Jameika)

Acil serviste yeni bir tehlike: Sentetik kannabinoidler (Bonzai, Jameika)

Evolution of new narcotic substances and methods of their determination

An overview of recent developments in the analytical detection of new psychoactive substances (NPSs)

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