Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis

Kasudhan, Kripa Shanker; Sarkar, Subendu; Gupta, Vishali; Gupta, Amod; Chakraborti, Anuradha

doi:10.1111/aos.13801

Cited by 12 publications

(11 citation statements)

References 65 publications

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“…On the contrary, Rao et al found that the diagnostic ability of the vessel density parameters of OCTA was only moderate 27. Another study revealed that cpVD is useful for differentiating moderate and advanced glaucoma, while MBR-T is useful for identifying early glaucoma 29. These previous reports are consistent with our results.…”

Section: Discussionsupporting

confidence: 92%

Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes

Kohmoto¹,

Sugiyama²,

Ueki³

et al. 2019

OPTH

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PurposeTo investigate the relationship between laser speckle flowgraphy (LSFG) and optical coherence tomography angiography (OCTA) measurements of the peripapillary retina and optic nerve head (ONH) in normal eyes and eyes with primary open-angle glaucoma (POAG).Patients and methodsOne eye from each of 46 normal subjects and mild and moderate/advanced POAG patients were included. ONH blood flow acquired by LSFG, circumpapillary vessel density (cpVD, a 250 μm-wide elliptical annulus around the optic disc), and intra-papillary vessel density (ipVD, a 1.5×1.5 mm scan field) acquired by OCTA were measured. Their values were compared among normal controls and patients at each stage of glaucoma using one-way ANOVA, and the correlation between measurements obtained by the two methods was examined by univariate regression analysis.ResultsONH tissue blood flow, tissue mean blur rate (MBR-T), and cpVD in the outer layer of the retina significantly decreased with the progression of glaucoma stage, although the latter showed no significant difference between normal subjects and mild-stage glaucoma patients. MBR-T was significantly correlated with cpVD, but not with ipVD, in the retinal outer layer.ConclusionA correlation was found only between MBR-T and cpVD in the retinal outer layer. A difference in MBR-T, but not in cpVD, was detected between normal controls and mild glaucoma patients.

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Section: Discussionsupporting

confidence: 92%

Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes

Kohmoto¹,

Sugiyama²,

Ueki³

et al. 2019

OPTH

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“…It does not not measure IOP directly but curvature changes of the limbal cornea which are related to IOP variation and are therefore considered representative of IOP changes 30. Recently, Vitish-Sharma et al31 demonstrated a weak correlation between the Sensimed Triggerfish contact lens sensor data output and IOP measurements taken using the Tonopen XL applanation tonometer.…”

Section: Discussionmentioning

confidence: 99%

Self-monitoring of intraocular pressure using Icare HOME tonometry in clinical practice

Cvenkel

Velkovska

2019

OPTH

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Purpose: To determine the value of self-monitoring of diurnal intraocular pressure (IOP) by Icare Home rebound tonometer in patients with glaucoma and ocular hypertension. Methods: Patients with open-angle glaucoma or ocular hypertension, controlled IOP at office visits, and at least 3 years of follow-up in the glaucoma clinic were included. Progression of glaucoma was based on medical records and defined by documented structural and/or visual field change. Patients were trained to correctly perform self-tonometry and instructed to measure diurnal IOP in a home setting for 3 days. IOP characteristics (mean, peak IOP, fluctuation of IOP as range, and SD of IOP) were documented and compared between the progressive and stable eyes. Results: Ninety-four patients (50 females) with a mean (SD) age of 57.1 (14.7) years were included. Among the 94 eyes from 94 subjects, 72 (76.6%) eyes had primary open-angle glaucoma, ten (10.6%) had pigmentary glaucoma, four (4.3%) had exfoliative glaucoma, and eight (8.5%) eyes had ocular hypertension. Thirty-six eyes showed progression and 58 eyes were stable. Patients with progression were older than those with stable disease (mean (SD) 65.8 (8.4) years vs 51.7 (15.3) years, P<0.001). The progression group had higher average IOP (mean (SD) 15.8 (4.0) mmHg vs 13.3 (3.7) mmHg, P =0.002), peak IOP (mean (SD) 21.8 (5.8) mmHg vs 18.6 (4.8) mmHg, P =0.01), and greater IOP fluctuation range (mean (SD) 11.6 (4.8) vs 9.1 (3.5) mmHg, P =0.011) compared to non-progression group. Conclusion: Self-monitoring of IOP using Icare Home tonometry provides more complete data on variability of IOP to assist in the management of glaucoma.

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“…A randomized multicenter clinical trial of 105 patients (141 cases), found 18% (with an additional 30% lost to follow-up presumably due to chalazia resolving) had complete resolution after warm compresses treatment with or without the addition of topical antibiotic or antibiotic steroid combination; despite similar outcomes, patients had higher satisfaction if they were given prescription medication 15. Of the cases that completely resolved, 86% resolved within 6 months; chalazia that resolved fully took less time than those which partially resolved (1.5 vs 2.2 months) 15. If chalazia were present for greater than 2 months, then they were more likely to benefit from the initial procedure being more invasive 15.…”

Section: Discussionmentioning

confidence: 99%

“…Of the cases that completely resolved, 86% resolved within 6 months; chalazia that resolved fully took less time than those which partially resolved (1.5 vs 2.2 months) 15. If chalazia were present for greater than 2 months, then they were more likely to benefit from the initial procedure being more invasive 15. Jackson et al noted that treatment success was 29% with warm compresses and chloramphenicol ointment within 3 months versus 72% after I&C 16.…”

Section: Discussionmentioning

confidence: 99%

Low level light therapy for the treatment of recalcitrant chalazia: a sample case summary

Stonecipher¹,

Potvin²

2019

OPTH

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PurposeTo evaluate the effects of low-level light therapy (LLLT) on the resolution of recalcitrant chalazia.Patients and MethodsThis was a single-site retrospective chart review of patients with chalazia, all of whom were unresponsive to previous pharmaceutical therapy or surgical intervention, who received a 15 min LLLT treatment in conjunction with a standard pharmaceutical regimen. A second treatment was applied 24 hrs to as late as 2 months if there was no evidence of progression of resolution in appearance.ResultsA total of 26 eyes of 22 patients with relevant history and treatment were reviewed, all with a history of prior pharmaceutical treatment for their chalazia. After a single 15 min LLLT treatment, followed by a standard pharmaceutical regimen, 46% of eyes (12/26) showed resolution of their chalazia. Resolution was noted from 3 days to one-month post-treatment. With a second treatment, the chalazia resolved in 92% of eyes (24/26). Only two eyes of the 26 (8%) required incision and curettage after LLLT treatment.ConclusionThe use of LLLT for the treatment of recalcitrant chalazia appears to be beneficial in patients who have failed topical and/or systemic therapy, significantly reducing the likelihood of requiring surgical intervention.

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Identification of unique proteins in vitreous fluid of patients with noninfectious uveitis

Abstract: High-throughput proteomic and pathway analyses have exposed the potential association of these proteins with autoimmune pathogenesis in uveitis. The exact role of most of the proteins in autoimmune uveitis is yet to be unfurled.

Cited by 12 publications

References 65 publications

<p>Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes</p>

<p>Correlation between laser speckle flowgraphy and optical coherence tomography angiography measurements in normal and glaucomatous eyes</p>

<p>Self-monitoring of intraocular pressure using Icare HOME tonometry in clinical practice</p>

<p>Low level light therapy for the treatment of recalcitrant chalazia: a sample case summary</p>

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