Identification of volatile and nonvolatile compounds in Citri Reticulatae Pericarpium Viride using <scp>GC–MS</scp>, <scp>UPLC‐Q‐Exactive Orbitrap‐MS,</scp> and <scp>HPLC‐PDA</scp>

Li, Jingxuan; Zou, S.; Yang, Wanling; Peng, Mengdie; Chen, Baizhong; Deng, Jinji; Wei, Minyan; Zheng, Guodong

doi:10.1002/fsn3.3181

Cited by 13 publications

(4 citation statements)

References 32 publications

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“…In contrast, several organic acids and fatty acids showed decreased levels in HLB-affected 9-year PCRC as compared to healthy PCRC. None of the depleted organic acids in the 9-year PCRC were identified as the key compounds, according to previous studies [ 26 , 39 ]. This indicated that most key organic acids that contributed to the bioactivity of PCRC were not influenced by HLB.…”

Section: Discussionmentioning

confidence: 71%

“…Terpenoids were the main volatile compounds identified in the essential oil of PCRC and possessed various biological activities, such as antioxidant, antimicrobial, anticancer, and antiallergic [ 25 , 26 ]. Most of the accumulated HLB-affected PCRC had been found to display numerous pharmacological activities.…”

Section: Discussionmentioning

confidence: 99%

“…Alkaloids and coumarins were the other two main bioactive ingredients identified in PCRC during storage, which both exhibited strong antioxidant and pharmacological activities [ 26 , 29 ]. A higher number of alkaloids and coumarins were accumulated in HLB-affected 9-year PCRC as compared to HLB-affected fresh and 6-month PCRC.…”

Section: Discussionmentioning

confidence: 99%

“…Both organic acids and fatty acids were the main bioactive metabolites accumulated in PCRC during aging processing [ 26 , 39 ]. In this study, a higher number of accumulated organic acids and fatty acids were identified in HLB-affected 9-year PCRC than in HLB-affected fresh PCRC and 6-month PCRC, indicating an improved antioxidant capacity by the accumulation of bioactive organic acids and fatty acids in HLB-affected long-term stored PCRC.…”

Section: Discussionmentioning

confidence: 99%

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Metabolomic Profiling Reveals the Quality Variations in Citri Reticulatae Pericarpium (Citrus reticulata Blanco cv. Chachiensis) with Different Storage Ages in Response to “Candidatus Liberibacter Asiaticus” Infection

Liang,

Xi,

et al. 2024

Foods

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Citri Reticulatae Pericarpium, especially the pericarp of Citrus reticulata Blanco cv. Chachiensis (PCRC), is an important edible and medicinal ingredient for health and pharmacological properties. Citrus Huanglongbing, a devastating disease that currently threatens the citrus industry worldwide, is caused by a phloem-limited alpha-proteobacterium, “Candidatus Liberibacter asiaticus” (CLas). The industry of cultivar Chachiensis has been suffering from HLB. Although HLB affected the quality of citrus fruit, whether the quality of PCRC was affected by HLB remains unclear. In this study, we compared the metabolite profiles between HLB-affected and healthy PCRC from three sources: fresh, 6-month-old, and 9-year-old PCRC, through the untargeted LC–MS method. Compared to healthy controls, various types of bioactive compounds, mainly flavonoids, terpenoids, alkaloids, coumarins, polysaccharides, and phenolic acids, accumulated in HLB-affected PCRC, especially in the HLB-affected 9-year PCRC. In particular, isorhamnetin, isoliquiritigenin, luteolin 7-O-beta-D-glucoside, limonin, geniposide, pyrimidodiazepine, scoparone, chitobiose, m-coumaric acid, malonate, and pantothenic acid, which contributed to the pharmacological activity and health care effects of PCRC, were highly accumulated in HLB-affected 9-year-old PCRC compared to the healthy control. Multibioassay analyses revealed that HLB-affected 9-year-old PCRC had a higher content of total flavonoids and total polyphenols and exhibited similar antioxidant capacity as compared to healthy controls. The results of this study provided detailed information on the quality of HLB-affected PCRC.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Metabolomic Profiling Reveals the Quality Variations in Citri Reticulatae Pericarpium (Citrus reticulata Blanco cv. Chachiensis) with Different Storage Ages in Response to “Candidatus Liberibacter Asiaticus” Infection

Liang,

Xi,

et al. 2024

Foods

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A field survey on the dietary use of traditional Chinese medicine in selected regions with the Cantonese, Hakka, and Teochew populations in Guangdong province, China

Peng,

Chen,

Wang

et al. 2024

Food Science & Nutrition

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The purpose of this study was to assess the dietary consumption patterns of traditional Chinese medicine (TCM) among the population in Guangdong province. Employing a cross‐sectional design, the survey was conducted from 2019 to 2021 to examine the inclusion of TCM in the diet of participants in Guangdong province. Information regarding consumption of TCM during the preceding 12 months was collected using a food frequency questionnaire. The participant cohort comprised a total of 3031 participants, consisting of 1081 Cantonese, 967 Hakka, and 983 Teochew individuals. The survey included 42 TCM, with consumption rates ranging from 2.6% to 47.3%. The top five TCM comprised Citri Reticulatae Pericarpium (47.3%), Lonicerae Japonicae Flos (47.0%), Codonopsis Radix (46.4%), Polygonati Odorati Rhizoma (43.1%), and Siraitiae Fructus (41.5%), along with Panacis Quinquefolii Radix (41.5%). These TCM possess recognized therapeutic properties within TCM for clearing heat, drying dampness, and detoxification. Within the top decile of 10 TCM, only Lonicerae Japonicae Flos was ubiquitous across all three sub‐populations. Nonetheless, 11 TCM from the top 20 and 17 TCM from the top 30 overlapped among the three sub‐populations. The study revealed substantial variability in the consumption rates of different TCM. Notably, those with traditional Chinese medicine effects of clearing heat, drying dampness, and detoxification exhibited higher consumption rates. Disparities in the consumption rates of these TCM were noted among the Cantonese, Hakka, and Teochew populations.

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Rapid Identification of Chemical Constituents of Sanhua Decoction in Vivo and in Vitro and the Metabolites of Rhubarb Anthraquinone Aglycone by Ultra‐High Performance Liquid Chromatography Coupled with Quadrupole Time‐of‐Flight Tandem Mass Spectrometry

Wang,

Ma,

Qian

et al. 2024

J of Separation Science

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Sanhua Decoction (SHD) is a classic prescription for the treatment of stroke in the clinic. Based on the combination strategy in vitro and in vivo, the chemical constituents of SHD were characterized by ultra‐high‐performance liquid chromatography coupled with quadrupole time‐of‐flight tandem mass spectrometry, and the metabolites of five effective anthraquinone aglycones (emodin, chrysophanol, rhein, aloe‐emodin, and physcion) of rhubarb in SHD were studied. A total of 222 compounds were isolated and identified in vitro, including 50 flavonoids and their glycosides, 41 coumarins, 22 anthraquinones, 22 tannins, 14 phenylpropanoids, 16 alkaloids, 18 organic acids and their esters, 14 lignans, six anthrones, and 19 other compounds. A total of 111 prototype components were isolated and identified in vivo. Among them, 26, 82, 101, and 46 prototype components and 87 metabolites were detected in plasma, urine, feces, and bile for the first time. This study provides a basis for the identification of chemical components in vivo and in vitro and the analysis of potential pharmacodynamic components of SHD, and provides a basis for further study of pharmacodynamic mechanism.

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Identification of volatile and nonvolatile compounds in Citri Reticulatae Pericarpium Viride using GC–MS, UPLC‐Q‐Exactive Orbitrap‐MS, and HPLC‐PDA

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 13 publications

References 32 publications

Metabolomic Profiling Reveals the Quality Variations in Citri Reticulatae Pericarpium (Citrus reticulata Blanco cv. Chachiensis) with Different Storage Ages in Response to “Candidatus Liberibacter Asiaticus” Infection

Metabolomic Profiling Reveals the Quality Variations in Citri Reticulatae Pericarpium (Citrus reticulata Blanco cv. Chachiensis) with Different Storage Ages in Response to “Candidatus Liberibacter Asiaticus” Infection

A field survey on the dietary use of traditional Chinese medicine in selected regions with the Cantonese, Hakka, and Teochew populations in Guangdong province, China

Rapid Identification of Chemical Constituents of Sanhua Decoction in Vivo and in Vitro and the Metabolites of Rhubarb Anthraquinone Aglycone by Ultra‐High Performance Liquid Chromatography Coupled with Quadrupole Time‐of‐Flight Tandem Mass Spectrometry

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