Identification of α-glucosidase inhibitors from<i>cyclocarya paliurus</i>tea leaves using UF-UPLC-Q/TOF-MS/MS and molecular docking

Ning, Ziwan; Zhai, Lixiang; Huang, Tao; Jiao, Peng; Hu, Die; Xiao, Haitao; Wen, Bo; Lin, Chengyuan; Zhao, Ling; Bian, Zhaoxiang

doi:10.1039/c8fo01845f

Cited by 69 publications

(43 citation statements)

References 32 publications

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“…Extracts of Cyclocarya paliurus (CP) tea leaves inhibit α-glucosidase activity at an IC 50 value of 31.5 ± 1.05 μg/mL which is very much lower than the IC 50 value of 296.6 ± 1.06 μg/mL, i.e., of acarbose, the positive control ( Ning et al, 2019 ). The active components of the extract with α-glucosidase inhibitory activity were quercetin-3- O -glucuronide, quercetin, kaempferol-3- O -rhamnoside, kaempferol, genistein and asiatic acid [ Fig.…”

Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 95%

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An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

262

121

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Recently the use of bioactive α-glucosidase inhibitors for the treatment of diabetes have been proven to be the most efficient remedy for controlling postprandial hyperglycemia and its detrimental physiological complications, especially in type 2 diabetes. The carbohydrate hydrolysing enzyme, α-glucosidase, is generally competitively inhibited by the α-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia. Here we have reviewed the most recent updates in the bioactive α-glucosidase inhibitors category. This review provides an overview of the α-glucosidase inhibitory potentials and efficiency of controlling postprandial hyperglycemia of various bioactive compounds such as flavonoids, phenolic compound, polysaccharide, betulinic acid, tannins, anthocyanins, steroids, polyol, polyphenols, galangin, procyanidins, hydroxyl-α-sanshool, hydroxyl-β-sanshool, erythritol, ganomycin, caffeoylquinic acid, resin glycosides, saponins, avicularin, oleanolic acids, urasolic acid, ethanolic extracts etc., from various dietary and non-dietary naturally occurring sources.

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Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 95%

“…6 ]. Studies related to molecular docking have revealed that these components can occupy the active sites of α-glucosidase more easily than acarbose ( Ning et al, 2019 ).…”

Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 99%

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

262

121

View full text Add to dashboard Cite

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“…Such values were similar as previous reports with the energy of À10.0 kcal mol À1 for quercetin or À9.3 kcal mol À1 for kaempferol binding to a-glucosidase. 49 Hydrogen bonds and Pi interactions were also formed between their interactions with the enzyme (Fig. 3B).…”

Section: Molecular Docking Analysismentioning

confidence: 95%

α-Glucosidase inhibitors from Chinese bayberry (Morella rubraSieb. et Zucc.) fruit: molecular docking and interaction mechanism of flavonols with different B-ring hydroxylations

Liu

Zhan

et al. 2020

RSC Adv.

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“…Cyclocarya paliurus , known as Qing-Qian-Liu due to the resemblance of its fruit clusters to a string of old Chinese copper coins, is a sole species in this genus [4]. Because of its diverse functions, C. paliurus has attracted a lot of attention [5,6,7]. However, the natural forest resources are mainly distributed in the mountain areas that are hard to reach or some nature reserves [8].…”

Section: Introductionmentioning

confidence: 99%

Morphological Characterization of Flower Buds Development and Related Gene Expression Profiling at Bud Break Stage in Heterodichogamous Cyclocarya paliurus (Batal.) lljinskaja

Chen

Mao

Huang

et al. 2019

Genes

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Cyclocarya paliurus (Batal.) Iljinskaja, a unique species growing in southern China, is a multi-function tree species with medicinal, healthcare, material, and ornamental values. So far, sexual reproduction is the main method for extensive cultivation of C. paliurus plantations, but this is limited by low seed plumpness resulted from the character of heterodichogamy. Phenological observations have revealed the asynchronism of flower development in this species. However, its molecular mechanism remains largely unknown. To reveal molecular mechanism of heterodichogamy in C. paliurus, transcriptome of female (F) and male (M) buds from two mating types (protandry, PA; protogyny, PG) at bud break stage were sequenced using Illumina Hiseq 4000 platform. The expression patterns of both 32 genes related to flowering and 58 differentially expressed transcription factors (DETFs) selected from 6 families were divided four groups (PG-F, PG-M, PA-F, and PA-M) into two categories: first flowers (PG-F and PA-M) and later flowers (PA-F and PG-M). The results indicated that genes related to plant hormones (IAA, ABA, and GA) synthesis and response, glucose metabolism, and transcription factors (especially in MIKC family) played significant roles in regulating asynchronism of male and female flowers in the same mating type. The expression of DETFs showed two patterns. One contained DETFs up-regulated in first flowers in comparison to later flowers, and the other was the reverse. Nine genes related to flowering were selected for qRT-PCR to confirm the accuracy of RNA-seq, and generally, the RPKM values of these genes were consistent with the result of qRT-PCR. The results of this work could improve our understanding in asynchronism of floral development within one mating type in C. paliurus at transcriptional level, as well as lay a foundation for further study in heterodichogamous plants.

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Identification of α-glucosidase inhibitors fromcyclocarya paliurustea leaves using UF-UPLC-Q/TOF-MS/MS and molecular docking

Abstract: 11 potential α-glucosidase inhibitors in leaves of Cyclocarya paliurus were quickly identified by UF-UPLC-Q/TOF-MS/MS, and their inhibitory activities were verified in vitro and in vivo, as well as docked with homology model.

Cited by 69 publications

References 32 publications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

α-Glucosidase inhibitors from Chinese bayberry (Morella rubraSieb. et Zucc.) fruit: molecular docking and interaction mechanism of flavonols with different B-ring hydroxylations

Morphological Characterization of Flower Buds Development and Related Gene Expression Profiling at Bud Break Stage in Heterodichogamous Cyclocarya paliurus (Batal.) lljinskaja

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