Identificaton of 2,3-Dihydro-3,5-dihydroxy-6-methyl-4<i>H</i>-pyran-4-one Isolated from Lactobacillus pentosus Strain S-PT84 Culture Supernatants as a Compound That Stimulates Autonomic Nerve Activities in Rats

Beppu, Yoshinori; Komura, Hajime; Izumo, Takayuki; Horii, Yuko; Shen, Jiao; Tanida, Mamoru; Nakashima, Toshihiro; Tsuruoka, Nobuo; Nonomura, Katsuya

doi:10.1021/jf302355e

Cited by 18 publications

(10 citation statements)

References 15 publications

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“…It is possible that some compounds are of microbial origin. For example, b-cyclocitral is a cyanobacterial metabolite (Zhang et al, 2013) and 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one is an antioxidant produced by some Lactobacillus bacteria (Beppu et al, 2012;Hwang et al, 2013). However, both these compounds are also present in insectpollinated Eucomis species (Shuttleworth & Johnson, 2009, which suggests that they have a floral origin.…”

Section: Importance Of Floral Scentmentioning

confidence: 99%

Scent chemistry is key in the evolutionary transition between insect and mammal pollination in African pineapple lilies

2019

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Summary Volatile emissions may play a key role in structuring pollination systems of plants with morphologically unspecialised flowers. Here we test for pollination by small mammals in Eucomis regia and investigate whether its floral scent differs markedly from fly‐ and wasp‐pollinated congeners and attracts mammals. We measured floral traits of E. regia and made comparisons with insect‐pollinated congeners. We observed floral visitors and examined fur and faeces of live‐trapped mammals for pollen. We determined the contributions of different floral visitors to seed set with selective exclusion and established the breeding system with controlled pollination experiments. Using bioassays, we examined whether mammals are attracted by the floral scent and are effective agents of pollen transfer. Eucomis regia differs from closely related insect‐pollinated species mainly in floral scent, with morphology, colour and nectar properties being similar. We found that mice and elephant‐shrews pollinate E. regia, which is self‐incompatible and reliant on vertebrates for seed production. Mammals are strongly attracted to the overall floral scent, which contains unusual sulphur compounds, including methional (which imparts the distinctive potato‐like scent and which was shown to be attractive to small mammals). The results highlight the important role of scent chemistry in shifts between insect and mammal pollination systems.

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Section: Importance Of Floral Scentmentioning

confidence: 99%

Scent chemistry is key in the evolutionary transition between insect and mammal pollination in African pineapple lilies

2019

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“…In our previous study, the phytochemical profile of FHD using high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) analysis identified 2,3-dihydro-3,5-dihydroxy-6-methyl-4( H )-pyran-4-one, 5-hydroxymethyl-2-furancarboxaldehyde, and quercetin . 2,3-Dihydro-3,5-dihydroxy-6-methyl-4( H )-pyran-4-one was shown to increase the BAT sympathetic nerve activity and the body temperature above the interscapular brown adipose tissue in rats . Quercetin is also well known to display a thermogenesis-mediated antiobesity effect. , In a study by Kaşıkcı et al, quercetin showed oral bioavailability of about 24%, which was slightly lower compared to 52% of isoquercetin, another component of FHD.…”

Section: Discussionmentioning

confidence: 99%

Fruit of Hovenia dulcis Thunb. Induces Nonshivering Thermogenesis through Mitochondrial Biogenesis and Activation by SIRT1 in High-Fat Diet-Fed Obese Mice and Primary Cultured Brown Adipocytes

Song

Kim

Jung

et al. 2020

J. Agric. Food Chem.

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Brown adipocytes, which contain abundant mitochondria, use stored energy as fuel during a process named nonshivering thermogenesis. Thus, the pharmacological activation of thermogenesis in brown adipose tissue (BAT) has become a promising target for treating obesity. We investigated the effect of fruit of Hovenial dulcis Thunb. (FHD), a frequently used herbal treatment for liver diseases, on thermogenesis and its mechanism using primary cultured brown adipocytes and BAT of high-fat-diet (HFD)-induced obese mice. Thermogenesis-related factors including UCP1 and PGC1α increased with FHD treatment. FHD also increased mitochondrial biogenesis and activation factors such as nuclear respiratory factor (NRF)1 and oxidative phosphorylation (OXPHOS) complex. Furthermore, FHD increased the intercellular nicotinamide adenine dinucleotide (NAD + ) level and sirtuin 1 (SIRT1) activity, which may be responsible for the activation of the thermogenic reaction. Overall, our results suggest that FHD can be a novel option for obesity treatment due to its thermogenic action through mitochondrial biogenesis and activation.

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“…DDMP DDMP was identified as a major component with strong DPPH radical scavenging activity in the aqueous extract of BDM-X [29]. It is also isolated from several resources other than fungi, such as lactobacterium [43] and onion [44], and reported to have several physiological functions, such as being anti-inflammatory, anti-mutagenic and having cancer cell toxicity and affecting autonomic neurons. Tyrosinase inhibitory activity reported for DDMP is interesting because BDM-X has potential for cosmetic use [45].…”

Section: Selective Isolation and Quantification Of Major Ingredientsmentioning

confidence: 99%

Mushrooms as a Resource for Mibyou-Care Functional Food; The Role of Basidiomycetes-X (Shirayukidake) and Its Major Components

et al. 2022

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Mibyou has been defined in traditional oriental medicine as a certain physiological condition whereby an individual is not ill but not healthy; it is also often referred to as a sub-healthy condition. In a society focused on longevity, “Mibyou-care” becomes of primary importance for healthy lifespan expenditure. Functional foods can play crucial roles in Mibyou-care; thus, the search for novel resources of functional food is an important and attractive research field. Mushrooms are the target of such studies because of their wide variety of biological functions, such as immune modulation and anti-obesity and anticancer activities, in addition to their nutritional importance. Basidiomycetes-X (BDM-X; Shirayukidake in Japanese) is a mushroom which has several attractive beneficial health functions. A metabolome analysis revealed more than 470 components of both nutritional and functional interest in BDM-X. Further isolation and purification studies on its components using radical scavenging activity and UV absorbance identified ergosterol, (10E,12Z)-octadeca-10,12-dienoic acid (CLA), 2,3-dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one (DDMP), formyl pyrrole analogues (FPA), including 4-[2-foemyl-5-(hydroxymethyl)-1H-pyrrole-1-yl] butanamide (FPAII), adenosine and uridine as major components. Biological activities attributed to these components were related to the observed biological functions of BDM-X, which suggest that this novel mushroom is a useful resource for Mibyou-care functional foods and medicines.

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Identificaton of 2,3-Dihydro-3,5-dihydroxy-6-methyl-4H-pyran-4-one Isolated from Lactobacillus pentosus Strain S-PT84 Culture Supernatants as a Compound That Stimulates Autonomic Nerve Activities in Rats

Cited by 18 publications

References 15 publications

Scent chemistry is key in the evolutionary transition between insect and mammal pollination in African pineapple lilies

Scent chemistry is key in the evolutionary transition between insect and mammal pollination in African pineapple lilies

Fruit of Hovenia dulcis Thunb. Induces Nonshivering Thermogenesis through Mitochondrial Biogenesis and Activation by SIRT1 in High-Fat Diet-Fed Obese Mice and Primary Cultured Brown Adipocytes

Mushrooms as a Resource for Mibyou-Care Functional Food; The Role of Basidiomycetes-X (Shirayukidake) and Its Major Components

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