Identifikasi Bahan Kimia Obat Dalam Jamu Pegal Linu Yang Beredar Di Kecamatan Harjamukti Kota Cirebon

Zamzam, Muhammad Yani; Karlina, None Nina; Yesa, Kaori Roselina

doi:10.37874/mh.v3i2.547

Cited by 2 publications

(7 citation statements)

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“…Observations on packaging such as packaging type, production address, registration number, batch number, expiration date, dosage form, and herbal powder include color, odor, taste, and homogeneity. (Zamzam et al,, 2022)…”

Section: Herb Packaging Observation and Herb Powder Organoleptic Obse...mentioning

confidence: 99%

“…The ether fraction was collected and evaporated in a water bath prior to drying. The residue was dissolved with 8 mL of 96% ethanol and put into a vial (Zamzam et al,, 2022).…”

Section: ) Preparation Of Test Solution Plus Piroxicam (B)mentioning

confidence: 99%

“…One 10 mg crushed piroxicam tablet was placed into a 25 mL volumetric flask, 96% ethanol was added, shaken, and sonicated for 10 min. The mixture was filtered and the filtrate was placed in a vial (Zamzam et al,, 2022). Sample was put into a 250 ml Erlenmeyer flask, 30 ml of chloroformmethanol mixture (9:1) was added, and the mixture was shaken for approximately 30 minutes.…”

Section: ) Preparation Of Standard Solution Of Piroxicam Comparator (C)mentioning

confidence: 99%

“…Stationary Phase GF254 nm silica gel plates were cut to a size of 4 × 10 cm, then the KLT plates were activated using an oven at 105° for 30 minutes. Then the plate was marked with a lower limit of 1.5 cm and a creepage distance of 8 cm (Zamzam et al,, 2022) b. Mobile Phase for Identification of Allopurinol Then, 200 ml of n-butanol and 200 ml of 6N ammonium hydroxide were mixed and shaken using a separatory funnel; the lower layer was discarded and the upper layer was taken, from the upper layer (25 ml), and n-butanol (2.5 ml of n-butanol and ethanol (5 ml of ethanol were added (Indonesian Pharmacopoeia, 5 th ed, 2014).…”

Section: Preparation Of Silent Phase and Mobile Phasementioning

confidence: 99%

“…Ethyl acetate (60 mL), methanol (30 mL), and ammonia (10 mL) were placed in Erlenmeyer flasks and shaken until homogeneous (Zamzam et al,, 2022). d. Mobile Phase for Identification of Dexamethasone 10 milliliters of chloroform was placed in an Erlenmeyer flask, 40 ml of acetone was added, and the mixture was shaken (Ditjen POM, 1995).…”

Section: Mobile Phase For Identification Of Piroxicammentioning

confidence: 99%

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Identification of Medicinal Compound in Uric Acid Jamu by Thin Layer Chromatography Method

Zamzam,

Iin Indawati,

Nina Karlina

et al. 2023

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Jamu is one of the traditional medicines derived from natural ingredients distributing in Indonesia. In accordance with Permenkes No. 007 of 2012, Medicinal Compound (MC) are prohibited from being added to jamu products. Previous research has found that some of the products in public contain MC. The aim of this study is to determine the presence or absence of allopurinol, piroxicam, and dexamethasone in uric acid jamu. This research used 5 (five) samples of uric acid jamu, both those with and without distribution permits from The Indonesian Food and Drug Authority, randomly selected in Kedawung District, Cirebon Regency, West java, Indonesia. The identification method used in this study is Thin Layer Chromatography (TLC) with the stationary phase being silica gel GF 254. For the identification of allopurinol, the mobile phase is n-butanol: ammonium hydroxide: ethanol; for piroxicam identification, it is ethyl acetate-methanol-ammonia (6:3:1); and for dexamethasone identification, it is chloroform: acetone (1:4). Spot detection is done using ultraviolet (UV) light at 254 nm. The applied solutions are the test solution (A), the test solution with added allopurinol, piroxicam, or dexamethasone (B), and the reference standard solution (C). The research results from the 5 (five) samples of uric acid jamu identified one positive samples containing allopurinol, and all positive samples contained piroxicam and dexamethasone. Keywords: Jamu, thin-layer chromatography, allopurinol, piroxicam, dexamethasone

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Section: Herb Packaging Observation and Herb Powder Organoleptic Obse...mentioning

confidence: 99%

“…The ether fraction was collected and evaporated in a water bath prior to drying. The residue was dissolved with 8 mL of 96% ethanol and put into a vial (Zamzam et al,, 2022).…”

Section: ) Preparation Of Test Solution Plus Piroxicam (B)mentioning

confidence: 99%

Section: ) Preparation Of Standard Solution Of Piroxicam Comparator (C)mentioning

confidence: 99%

Section: Preparation Of Silent Phase and Mobile Phasementioning

confidence: 99%

Section: Mobile Phase For Identification Of Piroxicammentioning

confidence: 99%

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Identification of Medicinal Compound in Uric Acid Jamu by Thin Layer Chromatography Method

Zamzam,

Iin Indawati,

Nina Karlina

et al. 2023

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Wattiheluw,

Firdaus

2023

Nutriture.J.

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Background: Ibuprofen is a chemical drug used in analgesic and non-steroidal anti-inflammatory drugs (NSAIDs) which is widely used by the public, both with a prescription and without a doctor's prescription, to reduce pain and inflammation in rheumatic diseases. Ibuprofen is prohibited from being used in traditional medicines based on BPOM Regulation No. 19 of 2021 concerning guidelines for follow-up on monitoring results for traditional medicines, quasi-medicines, health supplements and cosmetics. Previous research found ibuprofen content in herbal medicine samples in the city of Cirebon. Therefore, it is necessary to conduct research on herbal medicine products for aches and pains that are sold in Pasar Besar Kota Malang that do not have a BPOM number. Objective: to identify the chemical drug ibuprofen in herbal medicine samples. Method: Ibuprofen in herbal medicine for aches and pains using the qualitative Thin Layer Chromatography method with a GF254 silica gel plate with a mobile phase of chloroform: methanol (9:1 v/v). Results: research showed that of the four samples tested, two samples tested positive for ibuprofen with an Rf value of 0.56. Conclusion: From the results of the research it can be concluded that there are still herbal medicines for aches and pains with the BPOM brand that are sold at Pasar Besar Kota Malang that contain Ibuprofen.

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Identifikasi Bahan Kimia Obat Dalam Jamu Pegal Linu Yang Beredar Di Kecamatan Harjamukti Kota Cirebon

Cited by 2 publications

References 1 publication

Identification of Medicinal Compound in Uric Acid Jamu by Thin Layer Chromatography Method

Identification of Medicinal Compound in Uric Acid Jamu by Thin Layer Chromatography Method

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