IDENTIFIKASI SENYAWA ANTIDIABETES SECARA in Silico PADA Carica pubescens Lenne &amp; K. Koch

Laily, Ainun Nikmati; Khoiri, Ahmad Nuruddin

doi:10.18860/elha.v5i4.3469

Cited by 6 publications

(6 citation statements)

References 7 publications

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“…It was also explained that the active compound of cysteine protease and papain in the plants of V. pubescens A. DC. had the ability as anti-diabetic compounds [8]. V. pubescens A. DC.…”

Section: Introductionmentioning

confidence: 99%

Local Knowledge: Sex Determination on Vasconcellea Pubescens A.DC in Java, Indonesia

Laily¹,

Purnomo²,

Daryono³

et al. 2021

Proceedings of the 1st International Conference on Education, Humanities, Health and Agriculture, ICEHHA 2021, 3-4 June 2021, R

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Vasconcellea pubescens A. DC. is a fruit commodity that has the potential to be researched and developed This plant is the only member of the Family Caricaceae found in Indonesia There are 3 areas in Java that are overgrown with this plant: Dieng Plateau, Bromo, and Cangar-Batu with an altitude of 1500 -2400 above sea level around the volcano area However, plants are known to have a variety of flower expressions in different trees It is necessary to know the determination of sex as an efficient effort inbreeding This research is a descriptive exploratory study with survey methods, semistructured interviews and strengthened by a questionnaire. Retrieval of data in this study using a simple random technique. Utilization of plants as sweets and as fresh fruit for direct consumption. The utilization of plant organs includes ripe fruit and seeds. The knowledge of the local community regarding the determination of sex in this plant is still limited.

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“…It was also explained that the active compound of cysteine protease and papain in the plants of V. pubescens A. DC. had the ability as anti-diabetic compounds [8]. V. pubescens A. DC.…”

Section: Introductionmentioning

confidence: 99%

Local Knowledge: Sex Determination on Vasconcellea Pubescens A.DC in Java, Indonesia

Laily¹,

Purnomo²,

Daryono³

et al. 2021

Proceedings of the 1st International Conference on Education, Humanities, Health and Agriculture, ICEHHA 2021, 3-4 June 2021, R

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“…The results of docking analysis are presented in various interaction models, to determine which interaction model to use is the one with the lowest energy. [15] Binding a nity is the strength of the interaction between two (or more) molecules that bind reversibly.…”

Section: Discussionmentioning

confidence: 99%

The Potential of Papain and Zingibain Proteolytic Against β-amyloid (Aβ) Protein in Senile Cataracts

Cahyana

2021

Preprint

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Purpose : The protein aggregation process that forms senile cataracts is related to the pathway for making amyloid structures. With age the increase in β-secretase activity increases. β- and γ-secretase are enzymes that catalyze Amyloid-β Precursor Protein (APP) into β-amyloid (Aβ) structure. So that the β-amyloid (Aβ) formed must be cleaved using an enzyme containing protease to break down the proteins contained in the enzyme papain (Carica papaya L.) and zingibain enzymes (Zingiber officinale). So the In silico test is needed to see the binding ability between the proteolytic effects of the papain enzyme and the zingibain enzyme on β-amyloid (Aβ) protein. Determining the proteolytic potential of the papain enzyme and Zingibain enzyme against β-amyloid (Aβ) protein. Methods : collecting data of papain, zingibain enzyme and protein from RSCB and NCBI predicting the proteolytic potential of papain and zingibain enzyme against β-amyloid (Aβ) with docking simulation by In Silico Study and data analysis was carried out. Results : The binding interaction model is 1 for the papain enzyme and 0 for the zingibain enzyme with the binding affinity value for the papain enzyme is -697.2 and for the zingibain enzyme is -873.5. Conclusion : The papain enzyme isolated from papaya latex (Carica papaya L.) and Zingibain found in ginger (Zingiber officinale) has the ability to form bonds with β-amyloid (Aβ) protein so it has the potential to be developed as a useful proteolytic as a preventive for senile cataracts.

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“…Secara detail, kandungan gizi pada Carica matang mengandung air 77% (b/b), protein 0,75% (b/b), lemak 0,07% (b/b), serat lasar 2,58% (b/b), karbohidrat 21,68% (b/b), Natrium 85,52 ppm, kalium 124,21 ppm, vitamin C 103,32 mg/100 g (Astuti, 2020). Selain itu, juga mengandung senyawa antioksidan flavanoid, polifenol, tanin, dan triterpenoid (Laily et al, 2018). Selain mengandung zat gizi, senyawa pewarna alami buah carica (C. pubescens) menarik untuk dikembangkan sebagai pewarna alami bahan pangan.…”

Section: Pendahuluanunclassified

Optimalisasi Pewarna Pangan Buah Carica (Carica pubescens) Melalui Teknologi Mikroenkapsulasi sebagai Sumber Antioksidan Alami

Hidayat,

Rarastiti,

Kirani

2024

Ghidza J. Gizi Kesehatan

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Buah carica (C. pubescens) mengandung 65,12 mg vitamin C, 1771,1 ug vitamin A, 24 ppm Ca, 1,2 ppm Fe dan 0,0254 % fosfor dalam setiap 100 gram buah. Selain itu, juga mengandung senyawa antioksidan flavanoid, polifenol, tanin, dan triterpenoid yang berperan menjaga kesehatan tubuh terutama pasca pandemi Covid-19. Buah carica (C. pubescens) matang belum dimanfaatkan optimal, sehingga memungkinkan dikembangkan sebagai alternatif pewarna pangan yang memiliki manfaat gizi dan kesehatan. Tujuan penelitian ini untuk meningkatkan pemanfaatan buah carica (C. pubescens) sebagai pewarna pangan alami melalui teknologi mikroenkapsulasi, mengetahui kadar senyawa vitamin C, serta senyawa karotenoid dalam mikrokapsul buah carica (C. pubescens). Metode; Penelitian menggunakan Rancangan Acak Lengkap (RAL) pola faktorial 3x2. Faktor perbandingan bahan enkapsulan terdiri dari 3 level dan faktor konsentrasi puree carica terdiri dari 2 level. Penelitian terbagi menjadi tiga tahap yaitu tahap preparasi sampel dan pembuatan puree carica, tahap pembuatan mikrokapsul carica, serta tahap analisis kadar vitamin C dan senyawa karotenoid mikrokapsul carica. Kadar vitamin C mikrokapsul sampel AB1 0,3030 mg; AB2 0,3913 mg; BB1 0,2199 mg; BB2 0,2999 mg; CB1 0,3540 mg; CB2 0,1697 mg. Kadar karotenoid total mikrokapsul per 100gram untuk sampel AB1 420,7 µg; AB2 447,6 µg; BB1 471,6 µg; BB2 585,2 µg; CB1 541,4 µg; CB2 552,8 µg. Hasil pembacaan SEM EDX menunjukkan bahwa terlihat bagian yang lebih gelap tersebar di seluruh bagian mikrokapsul. Perlu dipastikan sebaran tersebut adalah sebaran puree carica terlindung bahan enkapsulan atau sesuatu yang lain. Hasil SEM sampel AB2 dan BB2 menunjukkan gambaran persebaran yang jelas, sementara sampel CB2 tidak menunjukkan gambaran yang jelas. Metode enkapsulasi dapat digunakan untuk membuat produk mikrokapsul carica yang mengandung vitamin C dan senyawa karotenoid dalam kadar yang cukup sebagai sumber senyawa antioksidan. Namun, perlu evaluasi dalam metode mikroenkapsulasi untuk memperoleh hasil yang optimal.

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IDENTIFIKASI SENYAWA ANTIDIABETES SECARA in Silico PADA Carica pubescens Lenne & K. Koch

Cited by 6 publications

References 7 publications

Local Knowledge: Sex Determination on Vasconcellea Pubescens A.DC in Java, Indonesia

Local Knowledge: Sex Determination on Vasconcellea Pubescens A.DC in Java, Indonesia

The Potential of Papain and Zingibain Proteolytic Against β-amyloid (Aβ) Protein in Senile Cataracts

Optimalisasi Pewarna Pangan Buah Carica (Carica pubescens) Melalui Teknologi Mikroenkapsulasi sebagai Sumber Antioksidan Alami

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