Background: Nutrition for the children with special needs is a complex concern where the altered nutritional needs, physical problems, and behavioral issues are the sequence of reciprocal causes that influence each other. Objective: This study aimed to assess the nutritional status of the children with special needs based on anthropometric measures and hemoglobin (Hb) levels. Methods: This cross-sectional study enrolled 208 children (aged from 6 to 14 years old, 92 males and 116 females) from 2 special needs children schools in Menoufia Governorate, Egypt. The included children were classified into 2 age groups (6-<11 years old) and (11-≤14 years old). Sociodemographic history, type of disability, weight of mother at delivery were obtained from the caregivers. The nutritional status of the studied children was evaluated based on anthropometric measurements according to standard WHO Z scoring procedures and Hb levels (g/dl). Results: Down syndrome represented the highest proportion of the studied participants (23.3%), followed by ADHD (16.3%). In accordance with the WHO child growth standard, 16.3% of the studied children were underweight and 46.2% were severely stunted. Regarding BMI, 24% of the participants were at risk for overweight, 11.5% were at risk for obesity, and 7.7% were severely wasted. There was a high statistically significant difference between type of disability and BMI. Moreover, a statistically significant difference was found between BMI, socioeconomic status, and mother's weight at delivery. Besides, the mean Hb level was significantly lower in underweight females in the 11-≤14 years old age group. Conclusion. Malnutrition is a prevalent problem in children with special needs. Type of disability, socioeconomic status, and mother's weight during pregnancy are strongly related to malnutrition in these children.