Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

Gromisch, Elizabeth S.; Dhari, Zaenab

doi:10.2147/ndt.s256689

Cited by 9 publications

(8 citation statements)

References 180 publications

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“…[17][18][19][20] Prospective memory was measured using the Memory for Intentions Test (MIST), 21 an 8-item neuropsychological test in which the participant must remember to carry out specific tasks that are time or event cue-based. Working memory and processing speed were assessed with the oral version of the SDMT, 22 a frequently used and sensitive measure for MS-related cognitive impairment 23,24 in which the participant verbally matches the correct number to a series of geometric shapes. Verbal learning was evaluated with the RAVLT, 25 in which the participant is presented with a list of 15 words.…”

Section: Methodsmentioning

confidence: 99%

The Role of Cognitive Impairment on Physical Therapy Attendance and Outcomes in Multiple Sclerosis

Gomes

Ruiz

Raskin

et al. 2021

Journal of Neurologic Physical Therapy

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Background and Purpose: Many persons with multiple sclerosis (PwMS) experience cognitive impairments, which may affect their ability to engage in physical therapy. There is limited information on how cognitive impairments are associated with PwMS' ability to participate and improve their functional outcomes. This study aimed to assess the relationship between cognitive functioning and PwMS' attendance, total goal attainment, and functional improvement following physical therapy intervention. Methods: Participants (n = 45) were PwMS who participated in a larger self-management study and enrolled in physical therapy within the past 2 years. Objective cognitive functioning was examined using tests of prospective memory, retrospective memory, working memory, and processing speed, along with a self-report measure. Bivariate analyses were conducted to examine the relationship between cognitive functioning and each physical therapy outcome (session attendance, attaining goals, and changes in functional outcome measures), followed by logistic regressions with age, education, gender, and disability level as covariates. Results: Difficulty learning new verbal information was associated with a greater likelihood of "no showing" one or more of their physical therapy sessions. Reductions in working memory and processing

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Section: Methodsmentioning

confidence: 99%

The Role of Cognitive Impairment on Physical Therapy Attendance and Outcomes in Multiple Sclerosis

Gomes

Ruiz

Raskin

et al. 2021

Journal of Neurologic Physical Therapy

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“…The mean of the neuropsychological assessment of the patients was further analyzed by evaluating the deviation from the mean values based on the HC group. The results of each patient's neuropsychological tests were regarded as normal if they declined ,1.5 SDs from the mean values of the HC group; 23 patients were diagnosed as cognitively impaired when the results of at least 2 tests had declined. 24…”

Section: Clinical Assessmentmentioning

confidence: 99%

Short-Range Structural Connections Are More Severely Damaged in Early-Stage MS

Wu¹,

Sun²,

Huang³

et al. 2022

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Long-range connections are more severely damaged and relevant for cognition in long-standing MS. However, the evolution of such coordinated network damage in patients with MS is unclear. We investigated whether short-and long-range structural connections sustained equal damage in early-stage MS. MATERIALS AND METHODS:Sixteen patients with early-stage MS and 17 healthy controls were scanned by high-resolution, multishell diffusion imaging on 7T MR imaging and assessed cognitively. We investigated macrostructural properties in short-and longrange fibers and of microstructural metrics derived from 2 quantitative diffusion MR imaging models: DTI and neurite orientation dispersion and density imaging.RESULTS: Patients had significant WM integrity damage-that is, higher radial diffusivity and a lower intracellular volume fraction in the focal WM lesions. Compared with the healthy controls, the patients had noticeable microstructure changes in both short-and long-range fibers, including increased radial diffusivity, mean diffusivity, and axial diffusivity. Z scores further indicated greater damage in the short-range fibers than in the long-range fibers. CONCLUSIONS:Our findings demonstrate that more severe demyelination preceding axonal degeneration occurs in short-range connections but not in long-range connections in early-stage MS, suggesting the possibility that there are cortical lesions that are undetectable by current MR imaging.ABBREVIATIONS: AD ¼ axial diffusivity; EDSS ¼ Expanded Disability Status Scale; FA ¼ fractional anisotropy; f icvf ¼ intracellular volume fraction; HC ¼ healthy control; MD ¼ mean diffusivity; NODDI ¼ neurite orientation dispersion and density imaging; ODI ¼ Orientation Dispersion Index; RD ¼ radial diffusivity M S has been histologically characterized by the aggregation of inflammation, demyelination, gliosis, and axonal transection that ultimately leads to neurologic disability in young adults. MS can present with highly variable symptoms such as loss of vision, limb weakness, sensory loss, ataxia, and cognitive impairment. 1,2 Neuroimaging studies have helped to define the pathologic substrates and microstructure (eg, demyelination) alternations of this disorder in focal lesions and diffusely abnormal tissue. 3,4 While the specific WM fiber changes remain elusive, these local abnormalities in tissue microstructure are not enough to explain the clinically observed functional impairment. 5,6 Nevertheless, there is growing evidence that neurologic impairment in MS is determined more by specific large-scale functional network alterations than by local tissue microstructural alterations. 7,8 The subtle balance between short-and long-range connections contributes to the integration and segregation of the brain connectome. Connections of different lengths are found in different locations across the brain; short-range fibers are more abundant than their long-range counterparts, and the short-range fibers connect adjacent anatomic gyri that integrate multimodal informati...

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“…Multiple sclerosis (MS) patients might appear with a variety of physical and psychological symptoms [ 9 ]. MS individuals remain to be less active than their general population counterparts.…”

Section: Reviewmentioning

confidence: 99%

Physiotherapy for Multiple Sclerosis Patients From Early to Transition Phase: A Scoping Review

Warutkar¹,

Gulrandhe²,

Morghade³

et al. 2022

Cureus

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Multiple sclerosis (MS) is a chronic neurological disease that has an impact when they are at the most susceptible aspects of personal, professional, and social development. MS affects about 2.2 million individuals worldwide, with the majority of individuals experiencing relapses regularly. The progression of the disease's complex nature, the challenges in selecting the appropriate intervention, and a multitude of symptoms necessitate a systematic approach to the individual that includes both pharmacology and neurorehabilitation. Kinesiotherapy, exercise rehabilitation, massage, and hydrotherapy are all forms of physiotherapy that are used as part of rehabilitation. Physical exercise will mitigate the potential effects of akinesia and so enhance the functioning capacities of all bodily systems, regardless of the severity of the illness. An early examination by a physical therapist who is familiar with MS is advised to develop a customized training and/or lifestyle physical exercise program. Although hospital-based rehabilitation programs appear to have a higher impact, numerous studies have found that home-based rehabilitation is helpful. The constraint imposed by COVID-19 has an influence on the well-being of persons with multiple sclerosis. People with MS would be particularly affected, since they might be considered an at-risk group for serious COVID-19 in a variety of ways, and MS health-related data requirements increased significantly.

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Identifying Early Neuropsychological Indicators of Cognitive Involvement in Multiple Sclerosis

Cited by 9 publications

References 180 publications

The Role of Cognitive Impairment on Physical Therapy Attendance and Outcomes in Multiple Sclerosis

The Role of Cognitive Impairment on Physical Therapy Attendance and Outcomes in Multiple Sclerosis

Short-Range Structural Connections Are More Severely Damaged in Early-Stage MS

Physiotherapy for Multiple Sclerosis Patients From Early to Transition Phase: A Scoping Review

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