Identifying risk factors for depression and anxiety symptoms in patients with chronic lymphocytic leukemia

Robbertz, Abigail S; Weiss, David M.; Awan, Farrukh T.; Byrd, John C.; Rogers, Kerry A.; Woyach, Jennifer A.

doi:10.1007/s00520-019-04991-y

Cited by 10 publications

(14 citation statements)

References 37 publications

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“…32,33 We found factors associated with developing depression and anxiety such as female sex and higher comorbidity that are consistent with prior literature. 13,17,34 The association observed between non-White race and lower rates of CA-depression and CA-anxiety is interesting. The literature on the relationship between race and depression and anxiety is mixed: some retrospective claims-based studies show lower rates of these disorders among non-White patients, 13,30 while a prospective study that employed universal mental health screening found greater rates of psychological distress and depression in this group of patients.…”

Section: Discussionmentioning

confidence: 99%

“…24 On the other hand, the prevalence observed in our analysis is lower when compared to rates of depression and anxiety described in prospective cohorts of blood cancer patients. 16,17,25 A potential explanation for this difference are the varying methods used to ascertain depression and anxiety. Unlike our analysis that relied on claims data, which have strong specificity (but lower sensitivity) to determine the disorders of interest, studies with higher rates assessed these disorders using patient-administered questionnaires (e.g., Hospital Anxiety and Depression Scale 26 ), which have high sensitivity.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, some hematologic malignancies are incurable at diagnosis (e.g., myeloma), which may further increase levels of depression and anxiety. Prior studies examining mental health disorders among patients with hematologic malignancies suggest a concerning burden of depression and anxiety; [14][15][16][17] for example, a prospective cohort study of 74 patients hospitalized with acute myeloid leukemia (AML) showed that 39% had symptoms of depression. 16 Although these studies provide vital information regarding mental health disorders, many were singlecenter, included only one type of hematologic malignancy, or focused exclusively on either inpatient or outpatient settings, [14][15][16][17] thus limiting the generalizability of findings.…”

Section: Introductionmentioning

confidence: 99%

“…We also sought to identify factors associated with developing these mental health disorders in the first few months of a blood cancer diagnosis. Given prior literature on patients with cancer, we hypothesized that specific sociodemographic factors, such as female sex, and clinical factors, such as comorbidity and underlying pre-cancer mental health disorder, 13,14,17 would be associated with higher odds of developing depression or anxiety during the early part of the cancer trajectory.…”

Section: Introductionmentioning

confidence: 99%

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Precancer and cancer-associated depression and anxiety among older adults with blood cancers in the United States

et al. 2022

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For patients with blood cancers, comorbid mental health disorders at diagnosis likely affect the entire disease trajectory, as they can interfere with disease information processing, lead to poor coping, and even cause delays in care. We aimed to characterize the prevalence of depression and anxiety in patients with blood cancers. Using the Surveillance, Epidemiology, and End Results-Medicare database, we identified patients 67 years and older diagnosed with lymphoma, myeloma, leukemia, or myelodysplastic syndromes between 2000 and 2015. We determined the prevalence of pre-cancer and cancer-associated (CA) depression and anxiety using claims data. We identified factors associated with CA-depression and CA-anxiety in multivariate analyses. Among 75,691 patients, 18.6% had at least one diagnosis of depression or anxiety. Of the total cohort, 13.7% had pre-cancer depression and/or pre-cancer anxiety, while 4.9% had CA-depression or CA-anxiety. Compared to patients without pre-cancer anxiety, those with pre-cancer anxiety were more likely to have subsequent claims for CA-depression (OR 2.98; 95% CI 2.61-3.41). Other factors associated with higher risk of CA-depression included female sex, non-married status, higher comorbidity, and myeloma diagnosis. Patients with pre-cancer depression were significantly more likely to have subsequent claims for CA-anxiety compared to patients without pre-cancer depression (OR 3.01; 95% CI 2.63-3.44). Female sex and myeloma diagnosis were also associated with CA-anxiety. In this large cohort of older patients with newly diagnosed blood cancers, almost one in five suffered from depression or anxiety, highlighting a critical need for systematic mental health screening and management for this population.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Precancer and cancer-associated depression and anxiety among older adults with blood cancers in the United States

et al. 2022

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“…During the screening of 1786 records and relevant cross‐references, we identified 14 studies that examined the relation between physical comorbidity and anxiety in cancer survivors. Nine studies focused on specific tumor entities, 1 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 while five studies sampled patients with heterogeneous tumor entities. 20 , 21 , 22 , 23 , 24 These studies generally indicate some form of relation between physical comorbidity and anxiety.…”

Section: Introductionmentioning

confidence: 99%

Predicting anxiety in cancer survivors presenting to primary care – A machine learning approach accounting for physical comorbidity

Haun

Simon

Sklenarova³

et al. 2021

Cancer Medicine

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Depression and anxiety in cancer patient enrolled in clinical trials with serious adverse events

Peng,

Wang,

Sun

et al. 2023

Cancer Medicine

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ObjectiveDrug‐induced side effects, particularly serious adverse events (SAEs), often affect cancer patients enrolled in clinical trials. However, little is known about anxiety and depression in cancer patients who experienced SAEs. This study evaluated the prevalence of anxiety and depression in cancer patients enrolled in clinical trials who experienced SAEs and explored the risk factors.MethodsA multi‐center, cross‐sectional survey was conducted in hospitals affiliated with the University of Science and Technology of China from December 2021 to November 2022. A total of 112 cancer patients who experienced SAEs while enrolled in clinical trials, and who completed the informed consent process and study questionnaires, were included in the final analysis.ResultsThe rate of moderate–severe depression in cancer patients was 38.4% and that of moderate–severe anxiety was 13.4%. Among the patients who had moderate–severe anxiety, 93.3% had concurrent moderate–severe depression. Lower cognitive function and lower global quality of life were risk factors for depression in cancer patients who experienced SAEs. Pain, low emotional function, low global quality of life, and a high Impact of Events Scale score were risk factors for anxiety.ConclusionsCancer patients enrolled in a clinical trial who experienced SAEs tended to be anxious and depressed, particularly the latter. These results indicate the need to evaluate anxiety and depression, and mental health treatment among cancer patients with SAEs in clinical trials.

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Identifying risk factors for depression and anxiety symptoms in patients with chronic lymphocytic leukemia

Cited by 10 publications

References 37 publications

Precancer and cancer-associated depression and anxiety among older adults with blood cancers in the United States

Precancer and cancer-associated depression and anxiety among older adults with blood cancers in the United States

Predicting anxiety in cancer survivors presenting to primary care – A machine learning approach accounting for physical comorbidity

Depression and anxiety in cancer patient enrolled in clinical trials with serious adverse events

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