Identifying the features of an easy-to-use and intuitive dry powder inhaler for asthma and chronic obstructive pulmonary disease therapy: results from a 28-day device handling study, and an airflow resistance study

Abstract

Inhaler design providing good drug delivery with maximum ease of use may lead to more reliable therapy and improved control of airway diseases.

Measuring Peak Inspiratory Flow in Patients with Chronic Obstructive Pulmonary Disease

“…In a few studies, instructions were in line with patient information leaflets/Instructions for Use brochures. 7,51,53,56,59,62,68,71,72,74 In other studies, the instructions were not consistent with the Instructions for Use leaflet for the DPI being evaluated. 76,79 The contents of the Instructions for Use of the In-Check™ DIAL were consistent with instructions provided to patients using DPIs in one study 58 but not in others.…”

“…Overall, the PIF measurement details, including inhalation instructions, were provided or participants were referred to patient information leaflets in 35 of the 47 studies (74.5%; Supplementary Table 1 ). 7 , 12 , 21–23 , 26 , 32–34 , 48 , 51–66 , 68 , 70–72 , 74–76 , 78 , 79 Instructions for exhalation before the inhalation maneuver were provided in 14 (29.8%) studies and included “exhale gently to FRC,” 12 , 26 , 60 , 66 “complete exhalation,” 21 , 23 , 57 , 74 “exhale to RV,” 60 , 75 “deeply exhale,” 62 “breathe out completely,” 74 and “breathe out as far as comfortable”. 70 In one study, PIF was measured after patients were asked to inhale as they normally do.…”

“…Overall, the PIF measurement details, including inhalation instructions, were provided or participants were referred to patient information leaflets in 35 of the 47 studies (74.5%; Supplementary Table 1). 7,12,[21][22][23]26,[32][33][34]48,[51][52][53][54][55][56][57][58][59][60][61][62][63][64][65][66]68,[70][71][72][74][75][76]78,79 Instructions for exhalation before the inhalation maneuver were provided in 14 (29.8%) studies and included "exhale gently to FRC," 12,26,60,66 "complete exhalation," 21,23,57,74 "exhale to RV," 60,75 "deeply A gentle tap will dislodge the magnetic resetting weight, which will return the red cursor to a start position. When this has happened, the meter must turn through 180 degrees to return the magnetic weight to its resting positio...…”

Impact of PIF, Inhalation Technique and Medication Adherence on Health Status and Exacerbations in COPD: Protocol of a Real-World Observational Study (PIFotal COPD Study)

“…Parameters and test statistics will be calculated. To control for an undesired inflation of the type I error rate, the alpha value will be adjusted using the false discovery rate [41]. Missing or ambiguous CCQ scores will be calculated using the individual domains where possible.…”

AirFluSal®—Kolejny lek w terapii astmy czy znaczący postęp w przestrzeganiu zaleceń terapeutycznych?

“…Podobnie jest akceptowany przez dzieci. Wszyscy objęci badaniem pacjenci, bez względu na wiek i chorobę podstawową, byli w stanie uzyskać szczytowy przepływ wydechowy wynoszący co najmniej 35 l/min, który zapewnia uwolnienie dawki z inhalatora Forspiro [34].…”