Idiopathic aplastic anemia: a rare case report in Jammu and Kashmir region, India

Abstract

Idiopathic aplastic anemia is a pancytopenia disorder that is a rare but life threatening for both mother and fetus during pregnancy. Association of aplastic anemia with pregnancy is unclear but considered to be interrelated. Bone marrow transplantation is the most effective treatment for adult aplastic anemia but is inadvisable to perform during pregnancy because of the teratogenic effect of immunosuppressive agents or radiation therapy to the growing fetus. Supportive care, withdrawal from offending drugs and involving erythrocytes and platelets transfusion is a promising way to save the life. Here author present a case report of 36-year-old lady with idiopathy aplastic anemia. In this case medical investigation revealed severe anemia of unknown origin. The patient was treated with hematinics, blood transfusion and glucocorticoids. A healthy baby was delivered without evidence of hemolysis at her eight month and one week of pregnancy, the patient recovered and discharged with normal incidence. Being a rare case, it becomes a necessity to report such life-threatening disorder and management. Moreover, to our knowledge this is the first case reported of its kind from Jammu and Kashmir Division of India.

Managing aplastic anaemia in pregnancy: a unique obstetric challenge

“…If corticosteroids are administered, it is preferable to choose ones that cannot cross the placenta, such as prednisone, prednisolone, and hydrocortisone, to reduce exposure to the developing fetus's brain and the small risk of orofacial deformities. 7 There is also a case of aplastic anaemia treated with Eltrombopag (thrombopoietin receptor agonist) which was continued throughout the pregnancy but as the efficacy and safety of eltrombopag in pregnancy has not yet been established, its routine use should be avoided. 8 Most of the supportive treatments for aplastic anemias related to pregnancy is transfusion of blood products.…”