Idiopathic CD4 + T‐lymphocytopenia with opportunistic infection and non‐Hodgkin's lymphoma

Quiles, I.; Anaut, Pilar; Cibrián, F.; Gainzarain, Juan Carlos; Vega, L.; Andia, A

doi:10.1111/j.1365-2796.1995.tb00918.x

Cited by 10 publications

(3 citation statements)

References 7 publications

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“…5,6 However, only a few cases of non-Hodgkin lymphoma occurring in ICL patients in the English literature. [7][8][9][10][11][12] Moreover, to our knowledge, only two cases of EBV + NHL occurring in an ICL patient have been reported including the present case. 12 During the course of disease, the present case under discussion fulfilled the diagnostic criteria for ICL including ; (i) ＜ 300 × 10 9 /L CD4 + T-cells on five occasion ; (ii) no evidence of HIV-1 or -2, HTLV-1 or -2 infection, and (iii) no other cause of CD4 + T-cell cytopenia.…”

Section: Discussionmentioning

confidence: 91%

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EBV+ B-cell Lymphoproliferative Disorder Associated with Subsequent Development of Burkitt Lymphoma in a Patient with Idiopathic CD4+ T-lymphocytopenia

Kojima

Sakurai

Morita

et al. 2008

J Clin Exp Hematopathol

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We report here a case of idiopathic CD4 + T-lymphocytopenia (ICL) associated with Epstein-Barr virus (EBV) + lymphoproliferative disorder (LPD) terminating in Burkitt lymphoma (BL). A 33-year-old Japanese male was admitted to the hospital showing severe CD4 + lymphocytopenia and neutropenia that was diagnosed as ICL in 1993. Twenty months after the onset of disease, right cervical lymphadenopathy was detected. Biopsy of the specimen showed reactive lymph node hyperplasia and interfollicular B-cell hyperplasia. Ninety-one months later, polypoid tumors were resected from the bilateral nasal cavities and were diagnosed as BL. Immunohistological studies suggested the reactive nature of the initial lymph node biopsy specimen.

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Section: Discussionmentioning

confidence: 91%

“…5,6 However, in the English literature, non-Hodgkin lymphomas have rarely been reported in ICL. [7][8][9][10][11][12] We present here a case of EBV + lymphoproliferative disorder (LPD) associated with subsequent development of Burkitt lymphoma (BL) in a patient with ICL.…”

Section: Introductionmentioning

confidence: 99%

EBV+ B-cell Lymphoproliferative Disorder Associated with Subsequent Development of Burkitt Lymphoma in a Patient with Idiopathic CD4+ T-lymphocytopenia

Kojima

Sakurai

Morita

et al. 2008

J Clin Exp Hematopathol

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“…The literature regarding ICL patients with non-Hodgkin's lymphoma (NHL) is limited to a small number of case reports , moreover, in most of which the brain was not involved [5,[13][14][15][16]. To our knowledge, this is the first reported case of PCNSL affecting parenchymal brain tissue in the context of ICL.…”

Section: Ois and Relapses In Individual Patients As Shown In Our Casementioning

confidence: 99%

Multiple Opportunistic Infections and Primary Central Nervous System Lymphoma in a Patient with Idiopathic CD4+ T-lymphocytopenia

et al. 2012

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We describe a case of idiopathic CD4+ T-lymphocytopenia (ICL) in a 59-yearold patient who presented with various opportunistic infections. The patient was diagnosed with disseminated Mycobacterium avium infection, cytomegalovirus colitis and retinitis, and esophageal candidiasis. He was successfully treated with anti-mycobacterial drugs, ganciclovir, and fluconazole, respectively. However, the patient was diagnosed with primary central nervous system lymphoma, and then died of a Trichosporon beigelii sepsis during the 2 nd cycle of systemic chemotherapy. 18 JS Song, et al. • OIs and primary CNS lymphoma associated with ICL www.icjournal.org Case reportA 59-year-old man came to our hospital with the chief complaint of prolonged fever and watery diarrhea with no identified cause of disease. He had been in good health and had never traveled abroad or abused drugs. In addition, the patient had no history of blood transfusion, homosexuality, or any medical illness.Upon admission, the patient appeared generally ill and cachectic. His vital signs were as follows: blood pressure was 107/60 mmHg, pulse rate 84 beats/min, respiratory rate 19 breaths/min, and axillary body temperature 38.0℃. Upon physical examination, there was no skin lesion, lymphadenopathy, or hepatosplenomegaly. Laboratory studies showed white blood cells 1,230/mm 3 (segmented neutrophils 72%, lymphocytes 7%, monocytes 15%, eosinophils 6%), hemoglobin 11.3 g/dL, platelets 64×10 3 /mm 3 , blood glucose 105 mg/dL, total bilirubin 0.8 mg/dL, aspartate aminotransferase (AST) 68 IU/L, alanin aminotransferase (ALT) 33 IU/L, lactate dehydrogenase (LDH) 410 IU/L, and C-reactive protein 5.28 mg/dL.Chest computed tomography (CT), obtained with radiocontrast dye, showed multifocal ground glass opacities along with nodular consolidations in both lungs and abdomen and pelvic CT showed splenomegaly, heterogeneous liver attenuation, and enlargement of multiple mesenteric lymph nodes.

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Idiopathic CD4+ T Cell Lymphocytopenia Evolving to Monoclonal Immunoglobulins and Progressive Renal Damage Responsive to IL-2 Therapy

Wilhelm¹,

Weißinger²,

Kunzmann³

et al. 2001

Clinical Immunology

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Idiopathic CD4 + T‐lymphocytopenia with opportunistic infection and non‐Hodgkin's lymphoma

Cited by 10 publications

References 7 publications

EBV+ B-cell Lymphoproliferative Disorder Associated with Subsequent Development of Burkitt Lymphoma in a Patient with Idiopathic CD4+ T-lymphocytopenia

EBV+ B-cell Lymphoproliferative Disorder Associated with Subsequent Development of Burkitt Lymphoma in a Patient with Idiopathic CD4+ T-lymphocytopenia

Multiple Opportunistic Infections and Primary Central Nervous System Lymphoma in a Patient with Idiopathic CD4+ T-lymphocytopenia

Idiopathic CD4+ T Cell Lymphocytopenia Evolving to Monoclonal Immunoglobulins and Progressive Renal Damage Responsive to IL-2 Therapy

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