Idiopathic Hypercalcæmia of Infancy

A Case of Osteosclerosis with Hypercalcaemia and Renal Failure

“…A low-calcium diet induced a slight negative calcium balance, which is the usual finding; but small doses of cortisone were accompanied by a fall in faecal calcium (the intake being unchanged), and this is contrary to other reports (Forfar, Balf, Maxwell and Tompsett, 1956).…”

Oral Calcium-loading Test in Infancy, with Particular Reference to Idiopathic Hypercalcaemia

“…Unexpectedly high serum calcium levels occurred in the first three cases tested, and in the light of this we do not feel that the test should be applied to suspected cases of idiopathic hypercalcaemia if fasting calcium levels are greater than 12 mg./100 ml. The exaggerated response to oral calcium may denote hyperabsorption and is presumably part of the basic disturbance in idiopathic hypercalcaemia (Forfar et al, 1956 ;Morgan et al, 1956;Lindquist, 1962). It is consistent with the excess of vitamin-D-like activity found in the serum in some cases (Fellers and Schwartz, 1958 ;Kenny et al, 1963).…”

“…Two of the cases subsequently developed the full picture of idiopathic hypercalcaemia of the so-called mild type, and the test may therefore enable diagnosis to be made in the early stages of the disease before frank hypercalcaemia develops. The concept of idiopathic hypercalcaemia sine hypercalcaemia is not a new one (Forfar et al, 1956(Forfar et al, , 1959. The other two cases developed a more chronic, low-grade disorder and eventual growth retardation, classified as the severe type.…”

Thyrocalcitonin: Effect on Idiopathic Hypercalcemia

“…The identical twins studied had a mild form of the disease, which is attributed by Kenny et al(6) to abnormal metabolism of vitamin D. Forfar et al(7) have suggested that the severe form of the disease results when the mild form is not treated. The maximum response was reached after 1 hour.…”

“…The identical twins studied had a mild form of the disease, which is attributed by Kenny et al (6) to abnormal metabolism of vitamin D. Forfar et al (7) have suggested that the severe form of the disease results when the mild form is not treated. The identical twins studied had a mild form of the disease, which is attributed by Kenny et al (6) to abnormal metabolism of vitamin D. Forfar et al (7) have suggested that the severe form of the disease results when the mild form is not treated.…”