Idiopathic Hypoprothrombinemia

Giordano, A. S.

doi:10.1093/ajcp/13.6.285

Cited by 14 publications

(4 citation statements)

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“…Without information concerning the results of the thromboplastin generation test, any attempt at classification of published cases must be on the basis of probability only. Giordano (1943) described a case of idiopathic hypoprothrombina:mia in which the prolonged plasma prothrombin time was corrected by the addition of normal serum to the patient's plasma. Bleeding and coagulation times were normal, but no further relevant information is available.…”

Section: Discussionmentioning

confidence: 99%

Congenital Deficiency of Factor Vii

Pitney

1958

Australasian Annals of Medicine

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Summary Laboratory investigations are described in a female patient who suffers from a congenital hæmorrhagic disorder due to deficiency of Factor VII. The one‐stage prothrombin time using brain extract was greatly prolonged, but using viper venom was normal. All tests of the intrinsic blood coagulation mechanism, including the thromboplastin generation test, were normal. The patient provides the eighth recorded case of Factor VII deficiency with this pattern of laboratory findings. Evidence is presented which supports the concept that Factor VII consists of at least two components, deficiency of either producing a prolonged one‐stage prothrombin time using brain extract. Cases reported in the literature of Factor VII deficiency associated with an abnormal thromboplastin generation test and prolonged plasma venom time probably represent deficiency of the second component. The Factor VII component deficient in this patient is reduced early in therapy with “Dindevan”. The patient has three children, all with reduced concentrations of Factor VII. It is considered that the children represent the heterozygous state of Factor VII deficiency and that the defect is transmitted in a recessive manner.

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Section: Discussionmentioning

confidence: 99%

Congenital Deficiency of Factor Vii

Pitney

1958

Australasian Annals of Medicine

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“…The observation that throniboplastin generation is reduced in patients receiving coumarin drugs cannot therefore be accepted as evidence that Factor VII is concerned with prothrombin conversion. Atttlror Giordano, 1943Crockett et al, 1949 Landwehr ef a!., 1950Alexander et al, 1951Alexander, 1952van Belle, 1952 . (13-14) 28-105 sec.…”

Section: Observations On the Plasma Sf Patients Receiving Coumarin Drugsmentioning

confidence: 99%

The Function of Factor VII

Ackroyd

1956

Br J Haematol

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“…Biggs and MacFarlane (1953) give some details of three probable cases of factor VII deficiency described before the factor itself was adequately characterized. These were the cases of Giordano (1943), Crockett, Shotton, Craddock and Leavell (1949) and Landwehr, Lang and Alexander (1950). Frick and Hagen in 1953 review a case previously described as a hypoprothrombinaemia by Hagen and Watson in 1948.…”

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confidence: 99%