Idiopathic lymphocytoma cutis: a diagnostic dilemma

Abstract

Lymphocytoma cutis, also known as cutaneous B cell pseudolymphoma, represents a spectrum of disease that shares similar clinical and histological features and simulates cutaneous lymphoma clinically and histologically. Clinically it is manifested as asymptomatic, indolent, nodular lesions of different sizes varying between 2 and 5 cm, usually solitary, mainly on exposed area of the body like face and neck. The presence of polymorphous cell infiltrates comprising of T and B lymphocytes, plasma cells, oeosinophils, histiocytes and dendritic cells along with lack of atypical lymphocytes after incisional biopsy support diagnosis of pseudolymphoma. Final diagnosis is made on immunohistochemistry.

Borrelial lymphocytoma cutis: A diagnostic dilemma

“…Arunachal Pradesh showed higher seroprevalence rate (17.8%) as compared to other northeastern states. A single case of idiopathic LC was reported by Hasan et al .,[ 17 ] whereas Handa et al .,[ 18 ] prospectively screened 27 patients presenting with mono/oligoarticular disease of unknown aetiology for Lyme arthritis, wherein only 1 patient tested borderline positive for antibodies to B. burgdorferi , although only North American strain 2591 was used as an antigen in this study. Other isolated reports, include neuroretinitis secondary to Lyme disease seen in a South Indian female, hailing from the Nagarhole forest region,[ 19 ] and demonstration of Borrelia in the blood smear of a 15-year-old boy with Lyme disease from Shimla.…”

Case of immunoglobulin G4‐related skin disease: Possible immunoglobulin G4‐related skin disease cases in cutaneous pseudolymphoma only by immunohistochemical analysis

“…Face, chest and upper extremities are commonly involved sites. Lesions are usually asymptomatic, solitary, skin‐colored to violaceous plaques or nodules . The histological feature of cutaneous B‐cell pseudolymphoma is predominantly nodular or diffused infiltrate of lymphocytes admixed with a variable number of histiocytes, eosinophils and plasma cells .…”

“…Lesions are usually asymptomatic, solitary, skin‐colored to violaceous plaques or nodules . The histological feature of cutaneous B‐cell pseudolymphoma is predominantly nodular or diffused infiltrate of lymphocytes admixed with a variable number of histiocytes, eosinophils and plasma cells . The hallmark of cutaneous B‐cell pseudolymphoma is the formation of lymphoid follicles containing a mixed population of lymphoid cells .…”

“…The term cutaneous pseudolymphoma is used to describe non-malignant accumulation of T and B lymphocytes in the skin, and etiology is unknown in most of the cases. 13,14 Face, chest and upper extremities are commonly involved sites. Lesions are usually asymptomatic, solitary, skin-colored to violaceous plaques or nodules.…”

“…13,14 The histological feature of cutaneous B-cell pseudolymphoma is predominantly nodular or diffused infiltrate of lymphocytes admixed with a variable number of histiocytes, eosinophils and plasma cells. 13,14 The hallmark of cutaneous B-cell pseudolymphoma is the formation of lymphoid follicles containing a mixed population of lymphoid cells. 14 Thus, both clinical and histopathological features are similar between IgG4-related skin disease and cutaneous pseudolymphoma.…”